>>149568640 (OP)Solo alternate reality stories have a perception of not mattering, Earth 65 would need to be it's own line of books to sustain itself like Absolute or Ultimate.
There are no key issues set in Earth-65 other than Edge of Spider-Verse #2. Spider-Gwen's creator was given free reign to build her up and did a really bad job at world building so no one cares about Earth-65.
And it's not Gwen, the fictional character, wants to leave it's that Marvel wants to continue to sell Gwen books, but writers and editors don't want to keep track of her terrible continuity and poison the well for their other alternate reality lines of books.