Our favorite bogged hypothermic money bunny is really floundering in PubMed now. His medical team is steering his new interventions full schizo besides NAD/NR. So pretend you're his medical team, only smarter. Wat do? Maybe...

>Mechanistic insights into the anti-aging effects of Crocus sativus in a D-Gal-induced in vitro neural senescence model
>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0320572

>Nuciferine alleviates cognitive impairment by modulating endoplasmic reticulum stress in D-galactose-induced aging mice
>https://www.sciencedirect.com/science/article/abs/pii/S2212429225014373

>A Novel Approach to Herbal Skincare: Preparation and Evaluation of Daucus carota-Based Vanishing Cream
>https://scholar.googleusercontent.com/scholar?q=cache:OlDr3oL6gBAJ:scholar.google.com

>The use of betaine as a novel senotherapy
>https://theses.gla.ac.uk/85334/

>Non-pungent capsiate enhances longevity and healthspan in Caenorhabditis elegans via transient receptor potential (TRP) channels
>https://pubs.rsc.org/en/content/articlelanding/2025/fo/d5fo01607j/unauth

Any other ideas for performance/longevity/looksmaxxing interventions better than metformin, such that they have not already failed NIH'S ITP!?

>Photodynamic treatment increases the lifespan and oxidative stress resistance of Caenorhabditis elegans
>Highlights
>•A Photodynamic reaction with hypericin and orange light generates ROS in C. elegans.
>•Mild PDTr increases the lifespan and resistance to oxidative stress in C. elegans.
>•PDTr-induced oxidative stress resistance depends on NRF2, FOXO, AMPK, and p38 MAPK.
>•PDTr induces NRF2 and FOXO nuclear translocation and ctl-1, gst-4, and sod-3 expression.
>https://www.sciencedirect.com/science/article/pii/S0891584924004581

i worry that while he's trying to not die one of these supplements is going to kill him. maybe he should do that ancient wisdom from hippocratus- "instead of taking medicine, fast for a day"

what he really needs to tackle is the teleromes problem. that little stack of discs needs attention. if everyone was immortal we've have way bigger problems in society. even so, it's worth an attempt.

>>76399561
>what he really needs to tackle is the teleromes problem.
This is only part of the aging problem, but see...
>https://ijhespub.org/index.php/pub/article/view/151
>A landmark 24-week randomized controlled trial (Multistrain Probiotics) investigated multistrain probiotics in 124 patients with type 2 diabetes (T2DM) (62 receiving probiotics, 62 receiving placebo). The probiotic group was administered 30 billion CFUs daily of 14 strains, including Lactobacillus plantarum, L. fermentum, and Bifidobacterium bifidum. Telomere length, assessed using quantitative PCR, exhibited a lesser decline in the probiotic group (-0.08 ± 0.07, p < 0.001) compared to the placebo group (-0.10 ± 0.07, p < 0.001), resulting in a significant between-group difference (p = 0.036).

>Nutritional interventions and telomere integrity: emerging evidence on the impact of diets on cellular longevity
>https://repository.utm.md/handle/5014/32630

>>76399561
>>76399585
A recent review came out explaining more of the molecular dynamics of aging beyond just telomeres:
>Hepatocytes as Model for Investigating Natural Senotherapeutic Compounds and Their Effects on Cell Cycle Dynamics and Genome Stability
> In this review, we will explore the principal signaling pathways in mammalian cells that govern the cell cycle and cellular senescence, with a particular emphasis on how their dynamics, expression, and regulation have been modified through the application of senotherapeutic compounds. The second section of the review will identify key target genes for the metabolic engineering, primarily aimed at enhancing the accumulation of plant secondary metabolites with potential therapeutic benefits.
>https://www.mdpi.com/1422-0067/26/14/6794

>>76399445 (OP)
im 12 what is this

>>76399637
Trying not to hit "The Wall" by 112.

>>76399637
this dude is trying to live forever. possibly just an elaborate cover-story for ordinary vampirism though.

>>76399585
interesting. i'll look into that.

>>76399626
Whoa, "Table 1" from the Pussian Institute for Vodka Runes Biology or whatever there dun mogs Bryan's whole stack all day erry day.

>>76399719
20-Deoxyingenol, in particular, looks like it could be a good hit for this board's collective chronic Luigi syndrome.
>20-Deoxyingenol alleviates intervertebral disc degeneration by activating TFEB in nucleus pulposus cells
>https://www.sciencedirect.com/science/article/abs/pii/S0006295223004562

schizo thread

>>76400767
desu, believing all the "anti-aging" shit is fake after the first NIH ITP mice had statistically significant lifespan gainz is itself fairly schizo.

>>76399445 (OP)
Friendship ended with Dr Miller.
Chinese cell culture studies are now my best friend.

>>76399561
>what he really needs to tackle is the teleromes problem. that little stack of discs needs attention. if everyone was immortal we've have way bigger problems in society. even so, it's worth an attempt.
Telomeres are not an issue before the age of 150. Heart disease, diabetes, alzheimers, organ failure, sarcopenia and cancer will get you way before lack of stem cells becomes an issue.

>>76401622
>Heart disease, diabetes, alzheimers, organ failure, sarcopenia and cancer
These all have decently effective chemoprophylaxis out there already; the influencers are just particularly naive about doing that for cancer relative to other conditions.

>>76401778
Since this board is probably growing hella liver cancer from tren and loves boron, might as well post...
>Boric Acid and Hyperthermia Combination: A New Cancer Therapy in The Human Hepatocellular Carcinoma and Neuroblastoma?
>https://link.springer.com/article/10.1007/s12011-025-04746-3
>The combination of BA and HT exhibited a significant antiproliferative effect in both cell lines, with increased expression of Caspase-9 and p53 (p<0.05), and decreased expression of Akt-1 (p<0.05), compared to the control group.

ke... ke... ketobros!?
>Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence
>https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00797-1

New hair regeneration pathway just dropped courtesy of studying why moles (skin nevus kind) grow abnormal amounts of hair.
>The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst
>https://spj.science.org/doi/pdf/10.34133/research.0830
>We analyze the groundbreaking discovery that senescent melanocytes can stimulate hair follicle stem cells through the osteopontin-CD44 signaling pathway, challenging the conventional understanding of senescence.

>>76406036
TIL definitely don't stack your tren with hyaluronic acid supplements, but maybe rubbing them on head stimulates hair growth through that pathway...
>Hyaluronic acid promotes hepatocellular carcinoma proliferation by upregulating CD44 expression and enhancing glucose metabolism flux
>https://www.sciencedirect.com/science/article/abs/pii/S1567576925000244

>>76406056
There is also literature talking about hyaluronic acid as a carrier for improving penetration of polyphenols: https://www.mdpi.com/1999-4923/15/6/1751

Raspberry polyphenols are another known CD44 upregulator: https://www.mdpi.com/1420-3049/23/9/2103