Previous >>40368110

• Help, advice, guidance on meds and dosages
• HRT related medical experiences and research
• Availability and pricing of medications
• Rational and scientific discussion

See following post for a pharmacy list.

Survey: https://1drv.ms/xs/s!AudRJceTA5C9c2G5lCV2Avq0kQ0
▶ Survey data: https://1drv.ms/x/s!AudRJceTA5C9cyIWo6_X14AvHyM
▶ HRTGen Data Analysis: https://1drv.ms/f/s!AudRJceTA5C9gRLLWnbpdzlIxe4r
▶ HRT Info Sheets: https://1drv.ms/f/s!AudRJceTA5C9gQnyM7wxZcBGWRzW
▶ Pill ID: https://www.drugs.com/imprints.php
▶ DrugBank: https://www.drugbank.com/
▶ Basic HRT: https://apps.carleton.edu/campus/gsc/assets/hormones_MTF.pdf
▶ HRT ranges: https://www.hemingways.org/GIDinfo/hrt_ref.htm
▶ Powers Method: https://powersfamilymedicine.com/s/Healthcare-of-the-Transgender-Patient-V60.pptx
▶ Endocrine Society Guidelines: https://academic.oup.com/jcem/article/102/11/3869/4157558
▶ Transline Guidelines (with bicalutamide): https://transline.zendesk.com/hc/en-us/article_attachments/360047702053/TransLine_HRT_Guidelines_FINAL.pdf
▶ WPATH SOC: https://www.wpath.org/publications/soc
▶ TransDIY: https://www.reddit.com/r/transDIY
▶ Blood tests (US): https://www.privatemdlabs.com/, https://www.labsmd.com/
▶ Blood tests (UK, Ireland): https://www.medichecks.com/
▶ Blood tests (Canada Only): https://bloodtestscanada.com/
▶ Blood tests (Sweden): https://werlabs.se/
▶ Blood tests by mail: https://www.letsgetchecked.com/ DIY capillary blood samples. Expensive.
▶ Lab test guide: https://www.healthcare.uiowa.edu

▶https://diyhrt.market/ - general HRT marketplace directory
▶https://www.inhousepharmacy.vu/t-shipping.aspx- Has been popular in the US. Ships from Vanuatu to some countries.
▶euaibolitatgmaildotcom - Ships from EU to Worldwide.
▶https://unitedpharmacies-uk.md/(UK only) - Ships from HK.
▶https://unitedpharmacies.md/(US only) - Ships from HK.
▶https://alldaychemist.com/- Ships from India to some countries.
▶https://shape-shifter.webnode.page/- Ships from Turkey to Worldwide.
▶https://stayhealthynow.co/- Ships from Turkey to Worldwide
▶https://amazing4health.com/- Ships from Thailand to Worldwide.
▶https://favskinhouse.com/- Ships from Thailand to Worldwide.
▶https://goodstuffstore.net/- Ships from Thailand to Worldwide.
▶https://otc-online-store.com/- Ships from Russia to Worldwide.
▶https://www.weborderpharmacy.md/(US only) - Ships from India.
▶https://www.weborderpharmacy-uk.md/(UK only) - Ships from India
▶https://opengatelabs.com/ - Ships from US

i always try to bump /hrtgen/ before going to sleep but sometimes i still have a bit of life outside the internet so sometimes i can't and then the thread dies :/

should I lose more weight to a low BMI before starting pio? Right now I'm at 23 or something BMI, might be lower now

hi so i got my bloodtest results, can someone help interpreting them?

E2: 518.5 pg/ml
T: 43.236 ng/dl (1.5 nmol/dl)
SHBG: 68.8 nmol/l
Free Androgen Index: 2.1
DHEA-S: 510 ug/dl

my dose rn is 10 mg/week of EEn (voix celeste, grapeseed oil)

what do? are those good? or bad? Also whys my shbg that low if E is so high

btw im 9.25 months on E now and my breasts have barely grown, could the high E be the cause of that?

also i drank a white monster like 5 hours before the bloodtest (i drink one everyday), i didnt know it has biotin, did that mess up the test?

Also, until 7 months ago i was on 6 mg/week of EEn from astrovials in MCT oil, and i also had an allergy to either the mct or benzyl benzoate cuz itd get really itchy. Anyways here are the results from 7 months ago

E 177.5 pg/ml
T 0.9 nmol/l (like 26 ng/dl)
DHEA-S 526.0 ug/dl
SHBG 26.5 nmol/l
Free Androgen Index: 3.5

So how come at such a lower amnt of E my T was like almost half of what it is rn? And also, why is my SHBG extremely low in both cases?
This old bloodtest shouldnt be wrong or influenced because i wasnt drinking any energy drinks (nor taking any supplements) back then

idk what to do now, are my new results bad, do i lower my dose, do i keep it the same? maybe having E be so high is stunting my changes (eg basically no breastgrowth in those 9.25 months, most that i got was breastbuds and some idk like fatness/little bumpiness there in the first 2 months or so). Dont see any facial nor body changes either, tryna weightcycle tho

>>40396635
white monster doesnt have white monster nvm about messing up the test, it should be fine

I'm quite convinced that if T is suppressed more stable esters are actually worse because of desensitization

>>40396635
DHEA-S is too high

>Also whys my shbg that low if E is so high
it could be due to genes directly controlling SHBG, it could be due to insulin resistance, insulin suppresses SHBG and increases adrenal androgens. other options are immunoassay interference for androgens (frequent, use LC-MS instead, if LC-MS, you definitely have too many androgens) or very mild congenital adrenal hyperplasia or an androgen secreting tumor.

>btw im 9.25 months on E now and my breasts have barely grown, could the high E be the cause of that?
there are anecdotes for and against. there's a paper where cis women congenitally deficient in gonadotropins when on hrt grow practically no boobs even after half a decade while those without functional gonads grow normal boobs on hrt. but then some trannies grow decent boobs on high estrogen.

>>40396806
desensitization is a myth, SHBG would decrease and gonadotropins would increase. desensitization could make gains from increasing estrogen doses disproportional but there would still be gains.

>>40397003
>congenitally deficient in gonadotropins
no my T was normal before starting hrt (idk exact numbers but it was normal)
and why does it matter anyway, like doesnt this regulate FSH and LH production, but were adding estrogen from outside so it doesnt matter if our sex glands (or wtvr) produce E themselves too

so anyways what would u recommend me to do now? i mean the shbg itself is fine its just low for the amount of E i have

and DHEA-S is high yeah, can that stunt feminization? i havent had any masculinization since starting hrt though, like no new facial hair coming in or anything like that

>>40397063
>and why does it matter anyway
high estrogen completely suppresses gonadotropins, reproducing the situation with congenital deficiency

>and DHEA-S is high yeah, can that stunt feminization? i havent had any masculinization since starting hrt though, like no new facial hair coming in or anything like that
no acne? waist to hip ratio is fine? dhea-s locally converts into dht, way more efficiently than t converts into dht. sebaceous unit has an abundance of enzymes necessary for this conversion and in fat this conversion happens too, dht selectively inhibits gluteofemoral fat.

>>40395655 (OP)
>all trannies here started using tgel and detrooned i guess
i just use tgel to plap my gf

>>40397156
well on face no acne no
so i used to not know i need to wash my face, and had often a few pimples esp on my forehead

now that i wash my face daily theyre mostly gone but sometimes theres still small red bumps, though not like pimples pimples with like pus in them. But definetly not to the point of acne though

on the top of my back i still have stuff but its not alot, so idt itd be called bacne (honestly i never looked at it but yeah)

hip waist ratio (like hip divided by waist) is more than 1 but ive gained weight very quickly when i started so it didnt have time to change and get better (cuz i gained the weight very quickly so alot of the fat got added before my levels stablized ig)


what can i do about the DHEA-S?

>>40397348
it's waist to hip ratio, not hip to waist ratio
0.9? grim, then dhea-s is probably due to insulin resistance and will decrease after fixing it. get on pioglitazone or metformin at least, start eating healthier (olive oil, mct oil, increase unsaturated fats), do short bouts of exercise through day and lose weight.

>>40397003
Anecdotal but moving my EV cycle from 4 days to 5 or 6 days gave me sore boobs again

am i stupid if i order from opengate directly to my home address

>>40397003
And SHBG/receptor desensitization are different things

>>40397542
>0.9? grim
0,85 (82,5/97)
>then dhea-s is probably due to insulin resistance
what? how? but i dont have diabetes so how do i have insulin resistance?
>eating healthier
ill look into it
>do short bouts of exercise through day
absolutely not
>lose weight
trying to (rn like 66 kg)

what are some signs that hrt may not be working? i am on een monotherapy 5mg/week for 1.5 years and am still trying to figure out blood tests in my shitty situation. i am quite anxious that its not working, are there any signs to look out for?

>>40398309
diabetes (type 2) is what happens when insulin resistance is too strong and the body can't produce enough insulin to compensate anymore

>>40398017
SHBG is correlated positively with estrogen exposure
estrogen receptor alpha knockout or natural human cases of estrogen insensitivity are characterized by no response of SHBG to any dose of estradiol
high dose estradiol completely suppresses LH - lower doses don't, and thus theoretical desensitization would result in rebound of LH
just think for a while before you peddle another genius theory from dr powers' subreddit making trannies unnecessarily worry about made up bullshit

should I take 15mg or 30mg of pioglitazone?
I'm pretty small if it matters, 5'4 105lbs

>>40398990
signs of non supressed testosterone like common erections, higher libido, hair growth, etc

bump

>>40399277
why are u so upset lol
i've never been on powers subreddit
receptors in hypothalamus/breast tissue/somewhere else have different profiles
it's something to try in any case, everyone should figure out what regimen they feel best with

sure cis womens menstrual cycle is more for reproduction than feminization but biology seems to have a preference for cycling stuff

Can gels or sprays be used for monotherapy or do you have to take an antiandrogen?

>>40402950
they can and are as good as injections, the problem is that it is really hard to get to levels necessary for monotherapy if you even can get to it at all, so youll probably need an antiandrogen

>>40402284
>why are u so upset lol
i told you why, you make people worry over absurd things that are contradicted by objective measures like response of SHBG and gonadotropins. practically all of feminization depends on estrogen receptor alpha. gonadotropins don't rise - there's no decrease in estrogen activity

>everyone should figure out what regimen they feel best with
i feel the same on all regimens. you're just vulnerable to placebo/nocebo.

>sure cis womens menstrual cycle is more for reproduction than feminization but biology seems to have a preference for cycling stuff
the same cycle that increasss breast cancer risk the more it repeats - and yet CAIS women who don't have it grow noninferior breasts

>>40399890
how bad is your baseline fat distribution, are you insulin resistant? the better these factors are, the lower dose you can use

>>40402950
gel if you apply on scrotum but depends how well you absorb

>>40400370
i feel like i have all of that stuff. is it possible that monotherapy just doesn't work on me? i hope i havent wasted a bunch of time, spending so many days anxious that its not working only for people to be dismissive and tell me that "it just takes time"

>>40378405
from inhouse, they're never failed me

>>40399277
if i have estrogen insensitivity then how did i grow breastbuds like 2 weeks on E? and that was with like 26 SHBG

>>40404200
and on my old bloodtest i tested both FSH and LH and they were both suppressed (<0.1 or <0.3 iirc, whatever units), wouldnt estrogen insensitivity cause them to be unaffected as u said? and then my T wouldnt of been suppressed either? or can this be like partial E insensitivity

>>40402987
>if you even can get to it at all, so youll probably need an antiandrogen
I'm asking if it's viable or what the dosages you need are

>>40403165
>gel if you apply on scrotum
What if you get an orchi? I guess there's no T to suppress but you still need good E levels

>>40403165
Estradiol gel can monotherapy if I cover my balls in it?

>>40404056
isn't inhouse ridiculously expensive now?
you haven't had a problem getting it in the us?

>>40404200
who said you have estrogen insensitivity?

>>40404241
>What if you get an orchi?
it changes nothing unless you're retarded and got rid of scrotum

>what the dosages you need are
one portion of oestrogel twice a day for example. it depends how much you absorb

>you still need good E levels
you only need 60 pg/ml then. one portion would surely be enough

>>40404338
I didn't get an orchi I was just wondering

>>40404338
I can only afford a big thing of the raw chemicals. How would one go about a gel-based monotherapy routine since I don't trust myself to make my own injections.

>>40404290
inhouse sux
dont use it they are always out of stock on everything

>>40404504
>How would one go about a gel-based monotherapy routine
https://groups.io/g/MTFHRT/wiki/37530

>since I don't trust myself to make my own injections
it's easier, and you can sterilize even with an Instant Pot, Duo Plus are the cheapest models to have a built-in option of sterilization and it was confirmed in studies to be capable of lab grade sterilization, killing even most resistant bacteria.

i think the best option is to make estradiol undecylate in MCT oil capsules, you could swallow (whole) like 2 mg daily orally and have high dose monotherapy levels while avoiding liver exposure.

>>40404241
>I'm asking if it's viable or what the dosages you need are
it depends on what youre using, your levels and the minimum you need to completely suppress LH FSH
usually its around 200pg/ml or more
the estimated dosage is 6mg/day for the normal application zones for 200pg/ml of E or much less for genital application
I was on gel early on HRT and was fully suppressed with just 125pg/ml and just 3mg/day of gel, it varies a lot
100-200pg/ml if post orchi

>>40404543
What would you use instead? If I could do informed consent through planned parenthood is that better?

How do you weigh out dosages in low milligrams? Do I need a sensitive scale.

>>40404610
for what? injections?

>>40404619
Let's say I am cooking up a batch of estradiol solution, say I need 500 milligrams. What do you like to use to weigh that out? Should I make myself a scale?

>>40404644
>500 milligrams
a cheap chinese 0.001 mg scale is enough for 500 mg. if it's off by a few mg, it's irrelevant. if you want to measure out just a few mg for a daily dose, then make a solution like for injectables, measure out the dose with an insulin syringe and swallow.

>>40404290
nah they're reasonably priced for me. I just get AAs from them, and cutting cypro down into 12.5mg from 50mg makes me only need to order once every 1.5 years. E tho from them yeah that can add up but I get those vials from Lena

where can i buy raws? i want to get into making my own injectables, someone told me taobao had them but i couldn't find any ;-;

Should I feel safe getting informed consent in the US? Or should I be worried they're gonna put me on a list and just DIY instead

>>40405551
didn't hear about palantir? ultimately, an AI will just check your Internet logs and determine you're a tranny. it's already too late. and democrats will do nothing about it, like they do since decades. you should already try to acquire required qualifications or at least find a gf/bf to marry to escape to the EU/Australia before it's too late

>>40405692
>didn't hear about palantir? ultimately, an AI will just check your Internet logs and determine you're a tranny.
Yeah I'm pretty sure both DIY and informed consent will both be monitored

>escape to the EU/Australia before it's too late
I've thought about that or canada. I'm stupid and picked a bad time to have a mental breakdown driving me to want to stop repping

>>40403134
CAIS women haven't had significant testosterone exposure, i don't think trannies get to use them as an example for anything

>gonadotropins must rise with receptor desensitization
i care about breast growth. SERMs like tamoxifen make it obvious that ER in breast tissue have a different profile than in the hypothalamus.

>i feel the same so everyone else must also feel the same!

>you're just vulnerable to placebo/nocebo.
because there are so many targeted well-run studies to draw from right?

>>40405878
>SERMs like tamoxifen make it obvious that ER in breast tissue have a different profile than in the hypothalamus
ironically, tamoxifen is antiestrogenic in the hypothalamus too and makes gonadotropins rise

>because there are so many targeted well-run studies to draw from right?
there aren't studies supporting your anecdotes so you shouldn't preach them as truth revealed

>CAIS women haven't had significant testosterone exposure
because it magically makes up for not cycling? what an absurd reasoning

May have fucked up, is this normal after injections? I used enanthate in caster oil so I thought it might be an allergic reaction but its rashing and irritated and Im hoping I didn't fuck up and give myself an infection

>>40406501
i clearly stated what i said as my opinion rather than fact
i don't think CAIS women are comparable to doing monotherapy at 200-400 pg/mL
anyhow i don't have much to lose, dogma is fine when the science is established but until then you're free to cite any studies that are actually related
i don't come here claiming to have perfect understanding of everything which i think is the point of this thread

>>40397165
Where does one get t-gel for this purpose I've been having erectile issues from dosing too much e that viagra hasn't been able to fix

>>40395655 (OP)
Im looking to use low dose estradiol topical on my face and perhaps other parts of my body for skin softening/smoothing. What % should I use? From what I can tell most studies use 0.01%, but is that optimal? Anyone get it from diy sources?
If there are no cheap options for diy, I have extra EV in castor oil I could use to make my own. Anyone have any experience in this? I've seen pharma recipes for versabase cream and hrt cream base but they use raws. anyone know if either is better or if there are cheaper/easier to get alternatives? If I dilute in more castor oil can I just apply that?
Any help would be greatly appreciated <3

is there a way to raise your t level slightly without going off e? I want my dick to work better. I was thinking about just lowering my injection dose from 4mg to 3mg

>>40409292
idk if my T level raised but lowering my dose did make my dick re activate a little so ig it works

>>40409292
boron to suppress SHBG and thus increase androgen bioavailability
i doubt androgens yield any benefits at female levels that aren't placebo

>>40405551
if you don't need it covered by medical insurance, DIY.

>>40409524
That bad huh?

>>40409730
Ic is fine and you get better meds

>get prescribed 5mg Medroxyprogesterone by doctor who doesn't know too much
>Friends tell me not to take it because it won't do anything
>Look up medical documentation
>seems giving this has been pretty standard for the last decade at least

What do, should I take the meds or not? Anyone have any experience with this type of prog?

>>40395655 (OP)
For estrogen valerate (which has a quick half life) what is the highest dose I can do every 5 days? Recomended dose is .1 mL but I find doing .12 and then a booster shot of .05mL after like 3 days may have helped things.

How high can I go and what's to stop me from doing a .2 mL shot or something like that?

I feel like it's not fully suppressing T

>>40409902
Even in the present day US?

I want to make the jump on HRT but I don't want to get breasts. I'm a boy who wants to get a more softer, and feminine appearance.

What do ¯\(ツ)/¯

(Please don't say binding I beg you)

>>40410112
Fuck it i'll just bump to .2mL to be safe and check in later regarding labs.

>>40410285
They have a section in the guide regarding preventing breast growth

>>40410325
Thanks, sorry I kind of touristed my way here and didn't read anything like a dumbass :(

>>40410145
I doubt diy is any safer but until something happens you can only speculate

at what e level does bone health become a concern? how long do you have to have low e to get osteoporosis?

https://www.webmd.com/women/normal-testosterone-and-estrogen-levels-in-women
This site says postmenopausal women have e levels from 0-30 pg/ml so I guess as long as it's higher than 30 you're good?

>>40410099
what is the reason that you want to take it for?

>>40410502
Iunno just for the benefits I guess? Like, the transition and mental health benefits, like why I take estrogen and finasteride and stuff. I'm going to be blatantly honest I just asked for it because I thought you were supposed to.

>>40410112
no way to tell without knowing your levels
unecessary high E levels increase cardiovascular disease risk (not by much still), can cause puffy nipples, interfere with fluid retention, libido, mood, etc
also why dont you just start injecting every 3 days if youre doing better with a booster shot

>>40410099
I wouldnt take anything thats not bioidentical

>>40410575
I'm careful not to fully nuke T, I'll adjust and try every 3 days as you suggest

>>40410587
That’s for Estrogens because conjugated has real risks, medroxyprogesterone is fine

>>40410549
there is no benefits
progestins are only used in cobination with E for gonadal suppression (like CPA) or if you cant/dont want to use progesterone for some reason
progestins also dont follow the same metabolic pathway as progesterone and wont have mental benefits at all or at least a big part of it, they only work by binding to, and activating progesterone receptors
progesterone is just a whole other thing that isnt necessary but its full of myths and exacerbated anecdotes but its up to you to use it or not

>>40410624
>I'm careful not to fully nuke T
why? you need to fully nuke it if on monotherapy

>>40410669
you don't go to 0.0 testosterone you can have like 90-95% suppression and that's good enough

>>40410642
Alright, thank you!

>>40410501
you need at least 50pg/ml
lower than that for up to 1 year is fine
postmenopausal women just live with the increased risk of developing osteoporosis but its not guaranteed that they will have it

>>40410686
you cant reach 0 T with E only, some of it comes from adrenal glands or other tissues
by "nuking" people usually mean 95% suppression

>>40410456
If they crack down idk if they would do it on DIY or IC first

>>40410112
>>40410727
Idk, my blood tests come back with T being undetectable and E around 280pg/mL with 0.15mL injections of 20mg/mL (3mg) EV once per week. Had normal cis male levels beforehand too. Results have been pretty good so far.
Although, those tests were done around the halfway mark instead of trough.

>>40410704
Thank you! I'll try to stay above that. Would you happen to have a source?

>>40410859
i think you need some test, its unhealthy if you have none, cis women have some too

do higher levels of estrogen=quicker changes?

>>40410929
>i think you need some test
what do you mean by this? i don't do the blood tests myself, i get everything through informed consent

>>40411015
testosterone

>>40411015
>>40411038
>testosterone
sorry i'm a bit illiterate, thought you were implying I did the blood test wrong.
ya you're probably right, i cut down to 0.1mL injections for a few months and T went up to 14ng/dL but E fell to 200pg/mL at halfway through the week. Maybe I should go back to that but I was worried E was too low, but perhaps that doesn't matter. Didn't feel very different at the time anyway.

>>40410920
Nta but Zhu et al. J Orthop Surg Res
(2021) https://doi.org/10.1186/s13018-021-02799-3 has some pretty good data (older menopausal women only in the sample but it’s probably pretty similar)

Picrel is chart with red smooth fit curve and blue 95% confidence interval. 50 pg/ml seems reasonable but do your own research. Just don’t be in the part that drops off a cliff xx

>>40411213
Should’ve posted both charts but just look at the study and interpret lumbar bmd on the scatterplot, the curve doesn’t capture how lopsided the data are

>>40408360
Anyone???
If i rub estradiol in castor oil on my skin will it absorb? One of you has to know

bump

Sup guys. I’m kind of desperate to see if anyone here has gone through something similar or has any clue what might be going on with me. I’ll try to keep it short:

Last year I started taking dexamethasone (high dose) because I thought it would help my transition. I already had signs of high androgens (lots of body hair, bad odor, etc.). I stayed on it for a few months and then stupidly stopped abruptly. Since then my body completely went off the rails and never recovered.

Since then, I’ve been dealing with:
>extreme hirsutism, hair growing all over my body much worse than before
>awful body odor, especially in my armpit, won’t go away no matter what
>very oily skin and nose
>muscle tremors and twitches in my legs, arms, and eyelids throughout the day
>upper lip tissue almost gone (it was always small but seems worse now, maybe hormonal?)

I tried taking hydrocortisone at a physiological dose thinking my HPA axis had “collapsed” after using dex, but it hasn’t helped, maybe even made things worse.
I’ve also tried 50mg bica, 0.5 duta, spironolactone, myo-inositol, zinc… nothing has improved the hair, odor, or other symptoms.

I live in a third-world country and don’t have access to hormone labs or a good endocrinologist right now.
Has anyone here experienced anything like this? Or has a theory about what could be happening or what I could try in the meantime? Anything. Supplements, meds, ideas, I’m open to suggestions.

If you need more details, I’m happy to share. Thanks a lot for any help you can offer.

>>40412532
>dexamethasone (high dose) because I thought it would help my transition
how much? you should take like 0.25-0.5 mg. cortisol ruins fat distribution. so you need just enough to suppress androgens.
hydrocortisone is trash, short half-life and expensive.

>Or has a theory about what could be happening or what I could try in the meantime?
maybe long-term suppression of shbg, higher peripheral production of androgens by increased ectopic fat

Is it normal to not really feel much sensitivity in my boobs after switching to Injection monotherapy? My breasts feel like they're still supple, but they dont really hurt like they were for the first 8 months I was on sublingual E

t.6mg/7 days, on my 3rd week of injections now. Before this I was on 5mg sublingual E and 100mg Spiro

>>40408360
>>40411268
you may need to heat up the oil as E raws will not dissolve easily on their own.
theoretically should work. i have seen the idea of putting red clover flowers in oil thus getting the estrogenic stuff into oil (i have yet to do this on my own).

im about to run out of e and can't restock rn. how fucked am i from the withdrawal? i hear remasculinizing after having no t for a while is even worse than just normal masculinizing is that true??

>>40413507
I think its just normal for the sensitivity to go down
>>40413775
Just find someone who gives out injectable for free

>>40413775
how long on hrt before? how long until you have hrt again?

>>40413790
Injectables for about two years, gonna run by next month probably, might be a year or more til i can get a job and buy hrt again

>>40413802 forgot to add more
what kind of withdrawal problems can i expect to have? I used to be on pills about a year before changing to vials, i had two months withdrawal between running out of pills and getting the first injection and i think it was the cause of some pretty epic urticaria

>>40413802
grim if you can't afford to buy a fucking vial. there's no "withdrawal", there's estrogen deficiency and associated with it menopausal symptoms like shift to abdominal fat distribution, osteoporosis and night sweats. what's your dose? can't you decrease it to bare minimum?

>>40413815
mood swings, hot flashes, fatigue, general aches and pains perhaps, and of course masculinizing assuming you still have balls. the worst of it will be over in ~1-2 months, except for the masculinizing part ofc

>>40413865
I've been already reducing my dose to like taking 17 days to take it instead of like every 10 days like I'm supposed to. my vial looks to be like a 10ml vial with 40mg een, idk i kinda forgot the exact numbers but i inject 0.20ml every 2 weeks now

>>40413889
I hear masculinizing from t rebound is worse than usual t masculinizing?>>40413865
I have like, 1/4 of the vial left i guess

>>40413896
inject less and more frequently. 2 mg/7 days or something.

>>40413904
>I hear masculinizing from t rebound is worse than usual t masculinizing?
i don't think that's true. it'll probably seem that way due to the normal masculinization combined with the loss of feminine features.
and it feels bad to be forced to go back, which also might make it feel worse

>>40413949
>Estradiol Enanthate (EEn) 400 mg/10 mL (40 mg/mL)
ok so since i draw 0.18ml which is apparently 7mg every 10 days, i should be like drawing... 0.1ml - ish (or a bit less) every week? i better gitgud at drawing in the right amount of air to the vial to make sure i dont waste the dose too i guess

bump

>>40414011
40 * 0.18 = 7.2 mg
40 * 0.1 = 4 mg
40 * 0.05 = 2 mg

>>40413216
yeah, I was taking like 2mg/day of dex, so… way too much, I know.

about hydrocortisone: agreed, it feels useless and just makes me feel worse honestly.

your theory about shbg + ectopic fat + androgens is interesting. do you think that low dose dexamethasone would fix it over time?

also, is even a low dose of dex dangerous long term? or is it kinda safe if kept that low?

thanks for the reply btw, i'm so very lost right now.

>>40415855
>also, is even a low dose of dex dangerous long term? or is it kinda safe if kept that low?
in one study hyperandrogenic cis women on 0.5 mg didn't have altered fasting glucose or C-peptide so it's probably safe.
>do you think that low dose dexamethasone would fix it over time?
yeah. also weight loss to lose that ectopic fat. metformin and pioglitazone reduce adrenal androgens and normalize SHBG. there's some study where dexamethasone 0.5 mg increases SHBG and another study where higher doses (2-4 mg) decrease SHBG so just don't go too high.

>>40415755
grim rationing hondose but i guess id rather do that than have no estrogen at all

>>40416020
it's not a hondose if you have simulated levels (~100 pg/mL). these levels are enough to suppress T in many people and since your gonads are suppressed since two years, the damage should guarantee they stay suppressed with a lower dose.

bompy

>>40412532
the fact you have this pic means your faketrans and obviously do not have any clue whatsoever about fashion or socializing or being normal in any capacity and should absolutely just kill yourself rather than invading any kind of normal people spaces you stink of male die immediately and painfully

>>40378854
>does anyone have experience with the open gate transdermal estradiol spray?
missed it while the other thread was still alive
this is what i started on before i moved to injections. i was able to do mono with it by doing 2-3 sprays twice a day. i never got tested while on it, but it was pretty apparent that i had effective t suppression after about 3 weeks. at the very least it's a safe though fairly expensive way to do mono without injections, though i'd recommend just doing injections as quick as you can figure out how to deal with the needles

>>40413775
what country are you in

>>40395655 (OP)
I'm doing 5mgs weekly cypio monotherapy and these are my levels at trough after 3 months, should I change anything? I'm doing subq and a little leaks out almost every time so that might be why my E is lower than expected.
Testosterone: 36 ng/dl

Estrodial: 179 pg/ml

>>40419754
it could be worthwhile to increase the dosage by just a bit to get e closer to 200 and t under 30. it's not bad, though, so i wouldn't change it very drastically

>>40419754
LH FSH?

>>40419481
im a retarded thirdy

>>40419928
disaster. i have a cypionate vial i got sent by the seller as an erroneous reship that i wouldn't mind parting ways with and just getting what i'm already using when the time comes, but i doubt it'd get out of customs in the states

Hey, everyone. I've been seeing a tele-health clinic here in Canada specializing in gender affirming care. Went through all the preliminary appointments and have the prescription ready to go. But, there are a few issues I'd like to have your opinions on, If you're willing to give it.

For the past 3 years I've been using 5-alpha reductase(5AR) inhibitor to successfully treat androgenetic alopecia(AA); I'm using both finasteride and dutasteride (I just wanted to absolutely obliterate DHT). I started treatment as soon as I noticed some thinning, so I managed to recover the little bit of hair lost, and there hasn't been an issue since. Were I to proceed with HRT with the clinic, I was told that as soon as my T levels are sufficiently suppressed, I would have to stop using the 5AR inhibitors. In addition, I was also told that after being on HRT for long enough, I would be taken off of spiro as well.

The clinic prescribes the HRT meds in oral form, with the fist blood test and titration adjustment in 3 months. Spiro is taken orally, and E is take in a partially sublingual manner; let dissolve under the tongue for 60 - 90 seconds, then swallow. E Injections aren't available in Canada, and transdermal methods are too expensive.

My major issue is, without 5AR inhibitors or spiro, my hair would be open to being destroyed by DHT. The clinic seems like it they won't budge on the outlined course of treatment. I'm not sure what to do, please advise. Also, what do you all think of way they expect me to take the HRT medications?

>>40395655 (OP)
So 4mg per injection makes sense to me because it's 40mg/ml but going to like 5 or 6 seems like it would be really difficult comparatively? Like 4mg is just one tenth of an ml. That's easy to draw into the syringe, but 5 or 6mg seems like a weird number that would be difficult to reliably draw

I have no experience with injections yet btw because my estrogen hasn't come yet and I've been sublingual so far. If I'm acting like a retard then let me know but how tf do you get 5 or 6 mg drawn into the syringe consistently

>>40420471
the syringe usually has little tick marks for hundredths of an ml

Hey, everyone. I've been seeing a tele-health clinic specializing in gender affirming care. Went through all the preliminary appointments and have the prescription ready to go. But, there are a few issues I'd like to have your opinions on, if you're willing to give it.

For the past 3 years I've been using 5-alpha reductase(5AR) inhibitor to successfully treat androgenetic alopecia(AA); I'm using both finasteride and dutasteride (I just wanted to absolutely obliterate DHT). I started treatment as soon as I noticed some thinning, so I managed to recover the little bit of hair I lost, and there hasn't been an issue since. Were I to proceed with HRT with the clinic, I was told that as soon as my T levels are sufficiently suppressed, I would have to stop using the 5AR inhibitors. In addition, I was also told that after being on HRT for long enough, I would be taken off of spiro as well.

The clinic prescribes the HRT meds in oral form, with the first blood test and titration adjustment in 3 months. Spiro is taken orally, and E is take in a partially sublingual manner; let dissolve under the tongue for 60 - 90 seconds, then swallow. E Injections aren't available here, and transdermal methods are too expensive.

My major issue is, without 5AR inhibitors or spiro, my hair would be open to being destroyed by DHT. The clinic seems like it they won't budge on the outlined course of treatment. I'm not sure what to do, please advise. Also, what do you all think of way they expect me to take the HRT medications?

>>40420811
>My major issue is, without 5AR inhibitors or spiro, my hair would be open to being destroyed by DHT.
you should see if it's an actual issue first since your circulating T and DHT levels would be greatly reduced

I haven't started the HRT yet. If I were to start, they'd want me to stop the 5AR inhibitors after a while, then also the spiro a while after that. That would, at some point, leave me with just oral E taken in a partial sublingual manner. Is that really enough to protect my hair? The fin + dut I've been taking for the past few years has nuked my DHT down to 31 picomole/litre; the lower bound for DHT in adult men and women are 1032 picomole/litre, and 138 picomole/litre, respectively.

>>40420846
I haven't started the HRT yet. If I were to start, they'd want me to stop the 5AR inhibitors after a while, then also the spiro a while after that. That would, at some point, leave me with just oral E taken in a partial sublingual manner. Is that really enough to protect my hair? The fin + dut I've been taking for the past few years has nuked my DHT down to 31 picomole/litre; the lower bound for DHT in adult men and women are 1032 picomole/litre, and 138 picomole/litre, respectively.

>>40420978
as long as your T is suppressed your DHT should not be an issue

How well does (3ish layers of) foil protect estradiol from light/UV? I goofed a little and ran out early, but I still have some left in my previous vial. I haven't been careful keeping it out of light because I didn't think I'd need jt, but the vial has been wrapped in foil as usual. It's not discolored at all or anything. Is it good to use?

>>40419032
Faggot

>>40416017
Thanks for the reply. Do you know if staying on low-dose dex (like 0.25–0.5 mg) for months or even years actually risks adrenal atrophy? Or is it low enough that the axis stays alive and you can just stop when you’re done?

I was wondering if any of you are trying Telmisartan at the moment for feminine fat redistribution ? Since Pio is difficult to have in Europe and Dr. Powers is also using Telmisartan for the same purpose as pio, I was considering trying it soon. I can have it prescribed for me easily where I live

>>40395655 (OP)
Has selective scamming (like you see in the darknet drug markets) been a thing in the modern diy HRT world

why do retards keep trying to take diabetic drugs thinking it'll help with fat redistribution

bump

pumb

>>40395655 (OP)
Ive never done bloods, I've been doing hrt for 2 years. I do 0.17 EEn in castor every 10 days. Im 5'9 135lbs. Does this sound like an appropriate dose?

Anyone ever hear of bica causing eye pain?

progesterone is literally magic
my sex drive is back and my tits are growing even faster

>>40395655 (OP)
where are you people getting your pio? double useful if whoever responds is from canada

been wanting to get my hands on some before october for a while now, and time's running short

>>40426962
it will help
you're the retard
read picrel and stop seething about science

Why isn't bica monotherapy a thing? wouldn't it be healthier than just regular estrogen since it keeps your balls going?

>>40426962
Pioglitazone? it absolutely does help increase the size of hips, thighs, and butt

also i'm not retarded i've been tested

how long should i stop taking any biotin supplements before a blood draw? will a few days be enough not to mess up my levels?

I’m stressing out because I think I just lost £100 worth of crypto

>>40436981
Update: I definitely did

I cannot stress this enough: double check the address

>>40398012
if it ships domestically i'm pretty sure it would be fine

>>40436981
How many boxes is 100 British monies

>>40436116
if you're a tranny worried about your testicular function you're not real trans

>>40437227
I got spiro and e
Basically I ordered my first 3 months supply

>>40437241
Actually 16 weeks supply not 3 months

>>40437214
would you just ship it to a P.O box if it's not domestic
am looking to order pio and really really really don't wanna get caught since I can only get it overseas/international

>>40437266
One box of 50mg cyproterone acetate will last for the 80 days if it has 20 pills
So you only bought one box?

>>40437239
I'm nonbiney. Now answer the question.

>>40437241
Oh fuck I'm stupid
I read cypro instead of crypto
Never mind

>>40437385
I don't know how bica monotherapy works
I heard bica is way more dangerous than cypro since it doesn't lower your androgens but blocks the receptor completely, especially with bone and muscle receptors so your chances of developing osteoporosis are far higher
At least on CPA and Spiro you have some androgens instead of virtually nothing

>>40437335
P.O. box couldn't hurt but i dont think you'd get in trouble if it's not a controlled substance.

>>40437385
Nta but I think you would have to use a pretty high dose of bica (which isn't cheap and can strain your liver) to block that much testosterone. You would be left with at or near postmenopausal levels of estrogen but would still grow some breast tissue.

>>40437421
I'm in canada and work in healthcare, it's like, imperative that I don't have a black mark of any kind regarding drugs on my record, even if unscheduled, I don't wanna be caught with it, I'll only order it as an absolute last ditch effort if I can't get my hands on it any other way, I'm willing to pay a double premium if I can find someone to order it for me

>>40437482
could you follow it up with a low dose e injection? Or would that defeat entire point and cause Hypogonadism?

>>40437582
I think you've just reinvented a normal hrt regimen

of course you can adjust hrt within a normal range to see what feels best for you but don't expect your testes to keep pumping out testosterone. Why would you even want them to if you don't want the effects of the T that they make?

>>40437623
I just want my dick to work, it's the only thing about T I like.

>>40437681
That's a different question and you should've just asked it, theres no great way to preserve penile function long term past using your penis.

HRT can change sexuality too though so you might not like using it as much if you ever get on it, you can't go in looking control everything.

>>40437793
it's not a different question. bica is shown to preserve erections better than other AAs.

I am on HRT already. idk why not hating every single part of my male body gets me treated like a crazy person in lgbt spaces.

>>40439028
>bica is shown to preserve erections better than other AAs.
nta but link studies

>>40437404
>I heard bica is way more dangerous than cypro since it doesn't lower your androgens but blocks the receptor completely, especially with bone and muscle receptors so your chances of developing osteoporosis are far higher
androgens are redundant for prevention of osteoporosis, they rely on aromatization and in fact bicalutamide has been proven to prevent osteoporosis completely
estradiol itself is sort of an anabolic steroid and it's capable of supporting musculature on its own
bicalutamide is only "dangerous" because of liver damage which is due to off-target activities, not related to androgen receptor, and is extremely rare among young patients

>>40439028
there are no such studies, only that bicalutamide preserves fertility. the structures related to fertility have an unique environment which very efficiently traps androgens and preserves fertility even on GnRH agonists (when FSH rebounds, even though testosterone is in castrate range)
based on rodent studies, estradiol supports erectile function during sex while testosterone supports erectile function outside of sex, spontaneous erections without which atrophy begins. for me it's enough to use it frequently to reverse any erectile dysfunction.

>>40436116
because bicalutamide is expensive and the whole stink around its much more liver damaging progenitor flutamide
and no, it wouldn't be healthier

>>40439260
>the structures related to fertility have an unique environment which very efficiently traps androgens and preserves fertility even on GnRH agonists (when FSH rebounds, even though testosterone is in castrate range)
nta but can you talk a little more about this? i've been looking for differences between gnrh agonists and antagonists

Sorry if this has already been asked, but is otokonoko okay to use again? I saw that the site went back up a while ago and forgot to ask about it. Haven't been keeping up with this stuff in general, honestly

>>40439178
https://www.auajournals.org/doi/10.1016/S0022-5347%2817%2936588-6
>No significant modifications in regard to number of nocturnal penile tumescence episodes, maximum penile circumference and total rigidity time were found before and after therapy.

>>40439453
this is in isolation not in conjunction with feminizing hrt retard
of course in isolation it's fine since it induces positive HPG axis feedback

>>40395655 (OP)

my retarded ass realized i was injecting 12mg weekly of een instead of 4mg because i can't do basic math
thankfully im only 3 months in but it freaked me tf out when i realized, probaly why i already got breast development lmfao

>>40439501
why would a small dose of estrogen significantly impact erections if your body is still making t? I don't understand.

>>40439260
>bicalutamide has been proven to prevent osteoporosis completely
proof?

bump

bumpo

>>40440725
https://pubmed.ncbi.nlm.nih.gov/20950306/
>were treated with bicalutamide (150 mg) monotherapy
>Bicalutamide preserves BMD, muscle strength and HRQL in osteoporotic men with non-metastatic locally advanced prostate cancer.
>BMD was maintained (+2.1% lumbar spine, +1.2% total hip and +1.1% forearm).
>No increase in bone turnover markers was seen over 1 year. Quadriceps muscle strength was maintained.

you think it's because of bicalutamide not getting somewhere? then consider this:

>Aromatase deficiency [...] Tall stature, osteopenia, osteoporosis, Type II Diabetes, hyperinsulinemia,

nightbump

>>40395655 (OP)
well, well, well, if it isn't my old friend /hrtg/
so I detransitioned over the last two years, and I would say I'm back at baseline male, save for the breast tissue that remains.
what is the best solution for me getting back on e? I had been doing 5ml ev (i do not remember the dosage but iirc e volume is consistent over most of these vials no?)
I still have a brand new vial that is not yet expired, but I went ahead and got more estrofem just in case I needed it, so I have both on hand at this moment. i had been fully transitioned already by the time i stopped, so all T supressed with only my injections.
i have not yet bought more cypro but i'm willing to do that if it helps. it's been a long time since I needed to do any of the early hrt things and most of that information has sort of left my head since i was mono ev for such a long time
thx for all you do /hrtg/

>>40445220
oh right, that's .5ml isn't it heh
yeah, it's just been a long time n i don't wanna blogpost about why i did it but i'd like very much to be back where i was two years ago. i miss my bobs a lot, they're totally gone :/

>>40445229
0.5 mL is still too much
0.05 mL is a low dose but might be enough
5 mg (which equals to 5 units on a U-40 insulin syringe with a 40 mg/mL vial) weekly is an ok dose
volume is not the same
bathtub vials have 40, 50, 60 mg/mL
big pharma vials have lower concentrations too
cypro, like progesterone, temporarily enlarge breasts due to fluid retention and reversible lobuloalveolar development. you don't need antiandrogenic doses for that, you could take 2 mg daily or 12.5 mg/3 days for example just for luteal phase levels of progesterone.

>>40445289
thank you, i think the number in my head might have been actual dose weight and not volume, you're right.
so, on AA, i didn't know it was actually possible for my t production to actually go back to normal. the last lab i did showed my t at almost nothing and my e's were way way too high. i think i have a screenshot i can post in a bit (tho ig it's not very relevant). just from what i have been experiencing over 2025 (morning wood, dense ejaculate, hair loss, dense body and facial hair that's just become impossible to hide) it feels as if my body has re-oriented itself as male hormonally. would it make sense for me to suppress it as fast and forcefully as I can with a strong AA like cypro? i had taken it for a solid year when I first started, i want to say i was taking ~12.5mg daily.
what i mean to ask is, what is approximately the best path for my body now? should i start again as if i were never transitioned or would mono be enough? i honestly have totally forgotten the process of ramping for (for lack of a better word) a noob. i am turning 29 soon. at 27 i was 5 years transitioned and everything went perfectly. i got real cocky with my decent genes and good reception to HRT and i do not intend on turning 30 without passing again :') i am mentally better now and i care again heh..

>>40445784
mono

I’m hopefully starting e in a month. Any advice or tips? Btw I’m 18, I weigh 53kg and I’m 5ft 10 (bmi just under 17)

>>40445905
yeah, i was hoping for as much. i got my pills 7 days ago and went straight to 6mg sub and i already have full on ED, it was almost overnight from starting lol. sad my chest isn't sore yet if some things are happening faster than others but i can be patient.

>>40446688
Just monitor your doses, get bloodwork done, etc. After like 3 months, I'd suggest gaining some weight. And be sure to exercise and sleep as much as you can

>>40448420
Thanks.

Does anyone have experience of asking your nhs gp for a blood test? (I’m in uk)

I've been taking sublingual estradiol valerate (progynova) for ~6 months now and want to increase my dose from 3 mg/day to 4 mg/day, but I'm not sure how to time the doses. So far I've been taking 1 mg every 8 hours to cover for how quickly it metabolizes sublingually, but what should I do with 4mg? Taking it every 6 hours would mean interrupting my sleep every night, but splitting it up evenly throughout my waking hours would mean my levels would be extra low early in the morning (and inconsistent overall). Does the latter cause long-term problems?

>>40445784
did you lose dick size over five years of transition?

if so, did de-transing bring it back?

also, I'm interested in your blog post abt why you detransitioned and are retransitioning, but no pressure.

>>40395655 (OP)
when you switch to injection monotherapy, how long should I keep taking my cypro? don't want to quit too early before my levels are good enough to block T

>>40450418
just stop taking it, doesn't matter

>>40450182
i would say that perpetual ED was probably the main change in that regard, and that ultimately made the point moot. did i lose some volume whenever i could manage to get 85% erect i don't think i ever really noticed.
i will say that the entire nature of my orgasms changed. they were way, way more intense and drawn out, but that might have also been a product of having to work much harder to get off which i didn't really ever need to be erect to do.

why detrans? idk to be honest i got really complacent with my looks, i passed just fine, and my body felt naturally poised for female transition cuz my hrt went so well. so well in my own opinion that keeping up with hrt felt like such a chore, and because of this, when it stopped providing immediate gratification it fell prey to depression and some pretty bad financial stability-related stress that still hasn't really gone away

but now i have a fair bit stronger resolve and i stopped being able to avoid mirrors. didn't help that i stopped right after i moved and began new work and life, that only made it easier to ignore. my boobs are gone, my face is a little more gaunt and nobody in my new life knows what to call me kek. someone thought i was ftm for the longest time. my spouse also did my injections for me (glute max) and i'm ashamed to admit i got tired of asking them for the service and i never learned how to do my thigh

>>40450501
also the brutal conditions and schedule of my new job (classified!) have been sorta perpetuating some mental imbalance in me as well, just wanna die after every shift
/blogpost

Has anyone in the US bought bicalutamide from otonoko? How did it go? Also should I get 50mg or 150mg?

I've been on mono 4mg een injections for six weeks and I want to detrans until my other meds arrive do I just go cold turkey or gradually reduce the dose

>>40395655 (OP)
my endo doesn't agree with using progesterone, but i still want to go on it, does anyone know how to get a referral specifically to an endo that is okay with progestorone? i have access to it through a local clinician, but i only want to do it with an endo, but i might as well ask about dosages here.
also is 4mg E(oral) 100mg Spiro a low dose? I was on 3mg sublingual

>>40397156
i've been getting face acne lately, does that mean high T?

It's been 2 weeks and 1 day. How do I find the strength to trust DIY HRT will just work in the long run? I was denied a bloodtest so I don't have any way of really telling what hormone levels are like other than small physical changes (No sign of emotional changes for me)

>>40452824
>I want to detrans until my other meds arrive
Why? You'll feel like shit for no good reason
>>40452871
No point using it, but only consider after your first year on HRT. 100/200mg boofed rectally.
>>40452898
Not necessarily.
>>40453070
Wait a few more weeks before getting a blood test. Honestly if you want a good picture I would wait until 8 weeks.

>>40453144
how often? should you do it cyclically? i haven't reached my one year mark but i heard you can wait even 2 years so i'm not too worried

>>40449203
are you doing blood tests to see your levels? 3mg seems kinda low for progynova
you can take it every 8 hours. 2mg + 1mg + 1mg

I heard somewhere that there’s been an increase of packages getting seized getting imported to the US, I desperately need cypro and I was going to order it from shapeshifters, but I’m (probably unrealistically) paranoid it’s going to get seized. Has anyone ordered from the recently and got it into the US?

>>40453192
If you bother, daily. There's not really any point though, injecting IGF-1 would probably be more helpful for boobs.
>>40453245
An anecdote isn't going to tell you whether YOUR package is going to be seized, so just order it.

>>40453245
I ordered estrogen valerate from France July 6th of this month. Got through customs just fine, although it was disguised slightly with mislabeling. I'd say you're probably fine though

>>40453255
I know I know… it’s just like, if loads of people are running into trouble id consider looking for some kind of alternative option

>>40452898
yes
women with complete androgen insensitivity have no acne at all, no sebum production
cis women with acne on undetectable androgens still benefit from androgen receptor antagonists
flutamide ~60 mg ends acne in 100% of cases. that would be equivalent to a very low dose of bicalutamide, you could take 50 mg/5 days for example.

>>40452898 #
yes
women with complete androgen insensitivity have no acne at all, no sebum production
cis women with acne without elevated systemic androgens still benefit from androgen receptor antagonists
flutamide ~60 mg ends acne in 100% of cases. that would be equivalent to a very low dose of bicalutamide, you could take 50 mg/5 days for example.

so i've been a lena customer for years, i started using her EV not long after she began selling it, i know people have different takes on her and on EV more generally but physically speaking my transition has gone really well on her stuff. however, i find i get really, really depressed and anxious on the day of my injection sometimes, which i presume is something to do with the stability of EV. like i can be having a perfectly fine week and then crash and burn once injection day rolls around. would switching to a more "stable" ester like EEn or another help with this?

What is the chance that a shipment to europe gets seized, i ordered cypro and oral e from outside the eu so im kinda worried

When I was repping I gym coped and now my body is fucked, how do I lose muscle mass and my diy is delayed from dashpct idk what to do

>>40456543
>my diy is delayed from dashpct
happened to me too, i wonder if its a widespread thing

>>40457425
>>40456543
either of you ordered from canada? looking to get some pio but don't wanna have it seized and need to know my odds

also, is it common to get delays?

>have been taking cypro 12.5mg + spiro 50 mg for years with lena E because I'm stupid and felt like it
>blood tests were great, i felt fine, kept at it
>spiro supply ran out and I've been lazy to reorder
>a few weeks now on just cypro
>no other changes
>hair fall is WAY down (i have a catcher in the shower drain and it always depressed me, but not now)
>balls are now shrunk 24/7

surely there is no way these two interact in any way.. or that the spiro could somehow interfere with cypro's blocking...

Should I give up on monotherapy? Been on hrt for 7 months now but can't seem to find a good dosage. My initial dose was way too high and my E was like 1000 so Ive been reducing. A couple months ago I was taking 4mg ev/5 days which left me with an E level of 220pg but T of 95ng and unsuppressed LH. Went back up to 5mg ev/5days and now my E is too high at 460 but T went down to 27. However my LH is still a little elevated at 1.1 though FSH is undetectable and DHT is at 16ng.
Why is my LH not completely reducing with such a high E level? I would like to get my E somewhere in the 200-300 range while keeping T low and suppressing my LH and DHT more but not sure what combo of meds to take.

>>40459839
stop taking EV, switch to a good ester like EEn

>>40460191
Nta but as a pharmacuck my options are EV and EC

>>40460191
>>40460540
Yeah I think I can only get Ev right now
Would a different ester even make a difference in DHT and LH suppression? I was of the impression that high E levels should take care of them but obviously that's not happening

ive been doing 4mg sublingual (2mg day 2mg night) + 100mg spiro (i know it shouldve been more.) for about 20 months and im diy'ing bica now. would there be reason to consider lowering e dose due to aromatization or is it not that significant?

>>40461454
It's possible that EV's spiky curve leads to it being unsuppressed for some time before your next dose. But honestly why not try something like 4.5mg/5d? LH and FSH technically don't really matter as long as your T is appropriate.
>>40461462
It shouldn't matter.

>>40436116
bica without estradiol is just going to be negative side effects. androgen receptors antagonized + normal male estrogen production just causes health issues and nothing else
im 20 months hrt and my dick works fine despite being on spiro for all of it

>>40462095
bica monotherapy is possible because local concentrations of T in the testes are like 100x which makes the aromatized E sufficient for normal function

>>40455859
I had the same thing with Een, and it was really a bitch, so I switched my cycle from 7 days to 6 days, and it went away