Previous >>40521528

• Help, advice, guidance on meds and dosages
• HRT related medical experiences and research
• Availability and pricing of medications
• Rational and scientific discussion

See following post for a pharmacy list.

Survey: https://1drv.ms/xs/s!AudRJceTA5C9c2G5lCV2Avq0kQ0
▶ Survey data: https://1drv.ms/x/s!AudRJceTA5C9cyIWo6_X14AvHyM
▶ HRTGen Data Analysis: https://1drv.ms/f/s!AudRJceTA5C9gRLLWnbpdzlIxe4r
▶ HRT Info Sheets: https://1drv.ms/f/s!AudRJceTA5C9gQnyM7wxZcBGWRzW
▶ Pill ID: https://www.drugs.com/imprints.php
▶ DrugBank: https://www.drugbank.com/
▶ Basic HRT: https://apps.carleton.edu/campus/gsc/assets/hormones_MTF.pdf
▶ HRT ranges: https://www.hemingways.org/GIDinfo/hrt_ref.htm
▶ Powers Method: https://powersfamilymedicine.com/s/Healthcare-of-the-Transgender-Patient-V60.pptx
▶ Endocrine Society Guidelines: https://academic.oup.com/jcem/article/102/11/3869/4157558
▶ Transline Guidelines (with bicalutamide): https://transline.zendesk.com/hc/en-us/article_attachments/360047702053/TransLine_HRT_Guidelines_FINAL.pdf
▶ WPATH SOC: https://www.wpath.org/publications/soc
▶ TransDIY: https://www.reddit.com/r/transDIY
▶ Blood tests (US): https://www.privatemdlabs.com/, https://www.labsmd.com/
▶ Blood tests (UK, Ireland): https://www.medichecks.com/
▶ Blood tests (Canada Only): https://bloodtestscanada.com/
▶ Blood tests (Sweden): https://werlabs.se/
▶ Blood tests by mail: https://www.letsgetchecked.com/ DIY capillary blood samples. Expensive.
▶ Lab test guide: https://www.healthcare.uiowa.edu

▶https://diyhrt.market/ - general HRT marketplace directory
▶https://www.inhousepharmacy.vu/t-shipping.aspx- Has been popular in the US. Ships from Vanuatu to some countries.
▶euaibolitatgmaildotcom - Ships from EU to Worldwide.
▶https://unitedpharmacies-uk.md/(UK only) - Ships from HK.
▶https://unitedpharmacies.md/(US only) - Ships from HK.
▶https://alldaychemist.com/- Ships from India to some countries.
▶https://shape-shifter.webnode.page/- Ships from Turkey to Worldwide.
▶https://stayhealthynow.co/- Ships from Turkey to Worldwide
▶https://amazing4health.com/- Ships from Thailand to Worldwide.
▶https://favskinhouse.com/- Ships from Thailand to Worldwide.
▶https://goodstuffstore.net/- Ships from Thailand to Worldwide.
▶https://otc-online-store.com/- Ships from Russia to Worldwide.
▶https://www.weborderpharmacy.md/(US only) - Ships from India.
▶https://www.weborderpharmacy-uk.md/(UK only) - Ships from India
▶https://opengatelabs.com/ - Ships from US

just made my own estrogen vials using the powder i bought 2 years ago. unfortunately i didn't have much powder to experiment. but estradiol enanthate does dissolve completely at 60 mg/mL with benzyl benzoate 40% and benzyl alcohol 3%. tomorrow i'm going to sterilize them with instant pot. unfortunately the cheapest model only has 11.6 psi so i had to pay a little more for 15 psi.
next time i'll buy undecylate to make 100 mg/mL.

>>40606642
is there any truth to this post?

>>40614002
estrone and estriol have short half-life and low affinity for estrogen receptors
unless there's an effect on LH suppression or attenuation of SHBG increase, these are just fairy tales dr powers uses to waste his patients time while an immense improvement in healthcare might be made with advocacy for oral estradiol undecylate capsules. there's a precedence with testosterone undecylate capsules, there are studies from the past century which prove it works and avoids first pass effect. why wouldn't he design a clinical trial with measurement of coagulation factors etc. and campaign for such capsules, not only for trannies but also cis women?

>>40614142
>oral estradiol undecylate capsules
tell me more, so basically its like injections but in pills and no e1? sounds cool but funilly, 1 injection per week is easier to my autistic brain than a daily pill

>>40614206
>sounds cool but funilly, 1 injection per week is easier to my autistic brain than a daily pill
i prefer injections too, but i think about people who fear injections or can only access pills, sublingual and gel. undecylate would change everything for them, it would be so much more convenient while preserving benefits of parenteral estrogen.

>so basically its like injections but in pills and no e1?
capsules, not pills. estradiol undecylate is dissolved in MCT oil and transported in a capsule to avoid first pass effect. since undecylate is an extremely long ester, it allows to preserve half-life long enough to dose it daily.

https://sci-hub.se/https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.1977.tb02941.x - parenteral-like estradiol:estrone ratio; 190 pg/mL after two weeks, dosed 0.5 mg estradiol decylate daily. estradiol decylate is an inferior ester to undecylate.
https://sci-hub.se/https://link.springer.com/article/10.1007/BF03350355) - 115 pg/mL after two weeks, dosed 0.25 mg estradiol decylate daily

>>40614206
>sounds cool but funilly, 1 injection per week is easier to my autistic brain than a daily pill
i prefer injections too, but i think about people who fear injections or can only access pills, sublingual and gel. undecylate would change everything for them, it would be so much more convenient while preserving benefits of parenteral estrogen.

>so basically its like injections but in pills and no e1?
capsules, not pills. estradiol undecylate is dissolved in oil and transported in a capsule to avoid first pass effect. since undecylate is an extremely long ester, it allows to preserve half-life long enough to dose it daily.

https://sci-hub.se/https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.1977.tb02941.x - parenteral-like estradiol:estrone ratio; 190 pg/mL after two weeks, dosed 0.5 mg estradiol decylate daily. estradiol decylate is an inferior ester to undecylate.
https://sci-hub.se/https://link.springer.com/article/10.1007/BF03350355) - 115 pg/mL after two weeks, dosed 0.25 mg estradiol decylate daily

bump

>>40614206
>1 injection per week
With EUn injections it's typically dosed once a month, which is even easier.
Injections are the best route of administration in almost every way, and they always will be.

>>40613841 (OP)
This is my first post here so sorry if my questions are stupid or medical wording is wrong, but I have a few to ask. any help is very appreciated <3

One; is there any truth to the idea that it's better to start on oral hrt (before switching to injections around 1yr) because it produces lower but more consistent levels & liver pass metabolites more closely resembling the early stages of cis female puberty? My only trans friend is convinced of this, did it herself, and she had great tits. I started at 4mg of oral and take 8mg now (along with 100mg of spiro) and am very surprised how much growth I've had so quickly. i've had people ask me "why don't you take it sublingually?" and im honestly not sure if that's better? but im worried about changing anything when it seems to be going about as well as it can right now. so what's the reality of it?

Two; I really want to switch off spiro (costly dehydrated, peeing a lot, light headed & the color leaves the corner of my vision if I get up too fast) but my doc only offered dutasteride or finasteride as alternatives (ive never heard of those as main AAs??). She said "your insurance likely won't cover bica" and I didn't push it. So I'm considering getting bica DIY (fuck spiro + bica supposedly promotes breat growth) but am concerned it'll make my t level drastically shoot up. Ik it won't cause masculinization because of how bica works but my doc will notice if my t shoots up on bloodwork. Are there other realistic options to DIY as an AA in the USA? I've heard cypro causes tumors and the only affordable GnRH agonist i've found is a nasal spray every 8 hours (buserelin) and that it can potentially cause diabetes. what is the truth & what is my best option?

>>40616034
>One
Sounds like honscience
Just do injections.
>Two
Just do injection monotherapy.
>the only affordable GnRH agonist
If you really want a GnRH buy relugolix from OpenGateLabs—it's an antagonist rather than an agonist, but it works just as well and is quite affordable. Plus they ship US domestic.

>>40616063
I don't trust monotherapy to keep my T down exclusively. No offense but the way it's been sold to me is as tee hee hon science just take estrogen...like you need something to keep your T suppressed besides one estrogen injection a week surely

i will look into the relugolix though, thank you

>>40616034
ask your doctor for depo-provera. it's once 3 months contraceptive - medroxyprogesterone, works like cypro. based on studies on men it's capable of completely suppressing testosterone on its own. idk how it is in your country but in mine depo-provera is only 13 $ per injection.
anyway, if your testosterone is within female range on e+spiro, it won't increase after discontinuation because spiro is only an androgen receptor antagonist in clinically used doses.

>>40616238
>I don't trust monotherapy to keep my T down exclusively. No offense but the way it's been sold to me is as tee hee hon science just take estrogen...like you need something to keep your T suppressed besides one estrogen injection a week surely
monotherapy is able to completely suppress gonadal testosterone with a high enough dose ALWAYS provided you don't have a tumor or EXTREMELY rare estrogen insensitivity (whose symptom is still growing taller way after puberty). estrogen suppresses gonadotropins. gonadotropins signal to Leydig cells in testicles to secrete androgens. it's only a matter of how high dose you need, but with 400 pg/mL (still safe) estrogen testosterone won't be suppressed only if it wouldn't be suppressed by cypro or GnRH agonists anyway.

bump

>>40613841 (OP)
could someone please give me a hand estimating what dose i should be on? I'm a bit lost desu

I've been on hrt since 19/02/2025 and I've gotten my most recent blood test back and I'm a bit unsure of how much to increase it by. I've obviously been hondosing myself but for my previous test done just after 3 months i was massively overdosing myself so I'm kinda wary of doing that again.

anyway here's my results after injecting 4mg EE from astrovials every 7 days for 2 months

>Estradiol - 431 pmol/l
>FSH - <0.30 U/l
>Free Androgen Index - 7.75
>Luteinising Hormone - 5 U/l
>Progesterone - 0.83 nmol/l
>Prolactin - 476 mlU/l
>SHBG - 28.35 nmol/l
>Testosterone - 2.196 nmol/l

So obviously my T is a bit too high and my estrogen is a bit too low but I think I'm closer to my target ranges than my previous test, which I'll post below

>>40618958
>Estradiol - 2040 pmol/l
>FSH - <0.30 U/l
>Free Androgen Index - 0.12
>Luteinising Hormone - <0.3 U/l
>Progesterone - 0.27 nmol/l
>Prolactin - 512 mlU/l
>SHBG - 170.9 nmol/l
>Testosterone - 0.21 nmol/l

so yeah obviously everything was much better supressed here but the shbg and estrogen were so ridiculously high it was basically useless anyway. this was after 2 1/2 months of 5mg EV every 5 days and 2 weeks of 5 mg EE every 7 days. All SubQ injections btw

when do you have to start going for breast cancer screenings
do you feel comfortable doing so?

>>40619014
>the shbg and estrogen were so ridiculously high it was basically useless anyway
bullshit. shbg is irrelevant for estrogen bioavailability. it only makes the gains less proportional, but the gains still happen. LH wouldn't be completely suppressed if there were less estrogen action, inhibition of LH is mediated via estrogen receptor alpha which is responsible for practically all feminization.
i fucking hate you for using trash molar units. you changed the vial which makes changing dosing more tiresome. i guess that it's estradiol enanthate 50 mg/ml without benzyl benzoate and it causes incomplete dissolution, decreasing absorption. or there was a problem with filtering. or you miscalculate the amount of fluid to draw.

>>40619670
sorry for the molar units, that's just what was in the pdf i was sent of the results. The vial is 40mg/ml, and it actually has benzyl benzoate.

I defintely messed up the dosages a bit during the first three months trying to use the airlock method, but I stopped being retarded and don't use that method anymore. But like.. yeah

>>40619948
here's a picture of the ingredients

>>40613841 (OP)
can i crush prog pills and rub them on my boobs? i dont want to put them up my butt

>>40621206
Put them up your butt, FAGGOT!

Sup legbutts. I'm injecting 0.40ml (vial with 40mg/ml) of estradiol enanthate every 14 days. Whenever I get to the last day before the next shot, my boobs feel more sensitive and my face gets way less oily. Does that mean I'm injecting too much and my levels only feel "normal" at the end? Should I lower the dose or just keep it as it is?

>>40621224
i dont wanna

>>40621319
It's the correct way

>>40623403
my throat ended up closing up like an hour after doing it so i will no longer open it and rub it on my breasts

>>40623611
You were warned

>>40621273
no, estradiol suppresses sebum production dose-dependently. it's more likely that the response is delayed.

Anyone else used astrovials before? Is there any one that has EEn that is better quality? Anyone know any online pharmacies (turkey, India, SA, ETC) that sell prep?

>>40625572
I bought my last vials on astrovials website and I received it like 5 days after I placed the order. But also I live in France so it sounded like the best way to get my hand on injections at the moment

>>40613841 (OP)
What should my diet look like if i want to get large boobs on hrt? I know its partly genetic, and my family generally are on the larger end of the boob scale but I also want to try and maximize with diet. Any tips?

bump

take rFSH to get big naturals

>>40613841 (OP)
I don't know what happened i switched to patches like 8 months ago (from injections) and i basically never male fail now even though i don't think i look any different?? my T is still the same, my boobs hurt more and i'm less horny yet i've never felt more hopelessly unpassing i feel like i'm going crazy.

>>40616034
fin and dut absolutely cannot be primary aas. dht is an androgen and can have benefits to suppress but it's not the main thing you need to suppress.
i think fin might be wise to use but in addition to an actual aa or proper monotherapy

If you take EUn do you have to do it im or can you do it subq?

How come otokonoko pharma doesn't accept ethereum anymore and it keeps saying order aborted because not enough estradiol available while being on stock?

>>40629406
whatever, just don't inject into rectus femoris

Quick question. Has anyone used 4NRX here? Any issues with them?

switching to diy EEn injection monotherapy from e+Spiro pills, is there anything I should test on my bloods other than e2 and free/total test?
>>40619448
Unless you're like 40 and had tits forever just lookup how to do a self exam.

>>40632573
>Unless you're like 40 and had tits forever
i'm 30 and have had tits for a few years

bumpo

>>40631483
why not? nta but interested cause i thigh inject

>>40634620
because this muscle is used a lot and absorption is faster

bump

Can high estrogen levels cause edema? For the past couple of months i've been getting a bit of swelling in my ankles after sitting on my ass all day at my dumbass office job. This coincided with accidentally dosing myself too high after switching to EUn, my levels were 350pg/mL at through. Thing is i already did my shot so i'm stuck like this for another month, it's not like i can adjust my dose super quickly with undecylate and see if the edema fixes itself.

Also i need some help interpreting LH, FSH and SHBG. I could not find any info on what they should actually be in trans women.
My SHBG is 91 nmol/L, the reference male range the clinic gave me is 11-54. Apparently 91 it's within range for cis women, does that look normal given my high E2 levels of 350 pg/mL?

My LH is 0.61 mlU/ml (reference range 1.24 - 8.62) and my FSH is 0.37 mlU/ml (reference range 1.27 - 19.26). These seem nuked enough given my T is clearly suppressed at 0.13 ng/mL, right?

>>40636997
yes, yes, yes

>>40613841 (OP)
Genuine question:
I'm on oestrogel 80g tube. Does the thickness of it once you've laid it down on the surface matter?

I'm fucking stupid can somebody read my labs and tell me whether this is good or bad

im stupid, im on 4mg sublingual (split in 2 doses) and 50mg bica and i want to wtart monoyherapy injections. which kind of estradiol do i buy, what needle do i need, where do i get needles, how often do i inject?

i'm in northeastern brazil
how do i buy the meds
do i just walk into the drugstore?

>>40638645
estrogen ok, testosterone is measured with mass spectrometry meaning very accurate measurement. 53 ng/dL with such high estrogen is concerning about adrenal androgens (you're supposed to have no more than ~15 ng/dL in such conditions). if you have any acne, you'll benefit from low dose bicalutamide.

>>40639154
sim. não precisa de receita aqui.
yes. its over the counter here

>>40613841 (OP)
weird question but I just found out I am balding, what can I do? would my mtf HRT have accelerated this? (I thought would prevent it)

>>40638923
The most bog standard dose and ester is 4mg EEn (enanthate) injected once a week. Cypionate has a very similar half life curve so you can alternatively use that. It's a well studied ester that is largely consistent between people and will allow you to adjust your dose quickly, unlike EUn (undecylate) which has a much longer half life (you can inject monthly), but is less understood and there is a lot of trial and error to fine tune your dose, and it takes months for your levels to stabilize before you can get tested. Valerate is also widely used and understood, but it has a very short half life and leads to less stable levels.

You need to calculate the actual volume in the syringe based on the vial's concentration, for example for a 50mg/ml vial, 4mg would be a 0.08ml dose, or 8 units in an insulin syringe.
Speaking of, buy small insulin syringes and do subcutaneous (subQ) injections, no need to muck around with changing needles or deadspace.

You pick a spot to inject on the region of your thigh in picrel. You just disinfect the injection spot and the top of the vial, you draw the same amount of air into the syringe as you are going to draw from the vial (8 units), you insert the needle into the vial straight down, inject the air, flip the vial upside down then draw that amount of liquid out. Don't worry if there are small air bubbles left, they are completely harmless for IM and subQ injections. Then stab yourself with the needle, not too violently but also in a swift motion without hesitation. Raise the plunger for a few seconds to see if you draw any blood so you don't inject in a vein - if you do just take it out and insert it again a couple of centimeters away, no big deal. Inject the dose, wait 10 seconds then take the needle out. I personally press down on the injection spot for a minute with an alcohol wipe to prevent anything from leaking out.
Don't forget to switch thighs and alternate injection sites between each injection.

>>40638923
Also in most countries you can just order insulin needles online, or walk into any pharmacy and say they're for your grandma or whatever. Get blood tests at through (right before your next dose) every 3 months and adjust your dose as needed so that your E is above 100 pg/ml and your T is suppressed.
>>40640942
I'm not aware of any pathways for E to be converted to DHT. Are you on prog? That can get converted to DHT. You sure you weren't balding beforehand? E won't make you go bald but it might make your hair thinner, which would make existent balding more apparent. Ultimately you'll have to get a blood test to see what your T, DHT and E levels are to figure out the cause.

boomp

>>40641331
i assumed since test leads to balding that test supressor (spiro) would help me. but I am obviously losing hair so idk. im gonna see a doc about it soon. my hair has been recently but just noticed the back part recently

>>40642160
my hairline has been receding*

isnt there a chance of accidentally piecing a vein or something with injections?

>>40642379
No, not unless you're injecting almost parallel to the skin

>>40642379
there is a chance, it's happened to me before. that's why you aspirate before you inject. the amount of oil you'd inject isn't dangerous even if you were to somehow inject your entire dose into a vein anyway, but the dose would be ineffective

>>40642742
does it hurt
how does aspirating prevent this exactly

>>40641267
4mg a week is enough? does 4mg daily sublingual just get absorbed a lot worse?

>>40643425
They're just not comparable, 4mg of pills are not the same as 4mg of gel or injections or patches. Even the same pills will get absorbed very differently based on whether they are taken orally or sublingually, and gel will be absorbed worse or better based on the area of the body it is applied to for example. Different administration methods with different ways of entering the body will each have unique absorption. Not even different injection or pill esters are completely comparable between each other, the same dose of valerate and enanthate injections will give you different levels for example even disregarding the half life (see image), and also 2mg of EV pills is equivalent to about 1.5mg hemihydrate.

4mg is a pretty standard EV dose and should put most people at over 200pg/ml at trough and lead to adequate T suppression.
You can use this calculator to play around with different doses https://transfemscience.org/misc/injectable-e2-simulator/

>>40643425
>>40644013
>4mg is a pretty standard EV dose
EEn*
Also keep in mind that injections will create a depot site which is slowly absorbed into the blood stream over the course of weeks. When taking pills sublingually they will basically enter the blood stream almost directly and get eliminated quite quickly which is why you need to take them multiple times a day. Swallowing pills will make them enter the blood stream slower through the digestive system, but the estradiol will be processed by the liver and a lot of it will be destroyed/turned into estrone, which is why that leads to lower levels than sublingual.

>>40642160
>im gonna see a doc about it soon
consider requesting a blood panel for both iron and thyroid levels as well

>>40643409
not really, i didn't feel anything different. there was just a tiny droplet of blood at the base of the syringe when i inserted it, then when i pulled back the plunger a little more came through. i actually took a photo of it because it was so unusual. when that happens you can just insert the syringe in a different spot, the tip shouldn't blunt too much from just one insertion.

if i'm moving at the end of the month how retarded would it be to order hrt and hope it comes in the next 3 weeks

>>40645493
To which country?

>>40640942
suppressing gonadotropins is not enough for congenital adrenal hyperplasia
add dexamethasone 0.5 mg or bicalutamide

>>40618958
You shouldn't be on any dose. Don't let drug pushers from 4chan tell you what to treat yourself with.

>>40621273
Definitely lower.

>>40646507
hi chud, see you in 3 years when you troon out