Anonymous
(ID: TP/PG9y4)
6/15/2025, 10:54:56 PM
No.507514410
[Report]
>>507514914
>>507515245
>>507516037
6/15/2025, 10:54:56 PM
No.507514410
[Report]
>>507514914
>>507515245
>>507516037
CRISPR used to remove extra chromosomes in Down syndrome and restore cell function
>Down syndrome is caused by an extra copy of chromosome 21, which leads to a range of developmental differences. Researchers have long sought strategies to correct this duplication, because current interventions do not address the added genetic material at its source.
>Recent work points to a promising approach with CRISPR-based methods.
>Ryotaro Hashizume and colleagues from Mie University in Japan report that it is possible to cut away the surplus chromosome in affected cells, which appears to bring their behavior closer to typical function.
>Down syndrome affects about 1 in 700 newborns in the United States. That added chromosome, known as trisomy 21, disrupts a range of important processes in the body, often resulting in learning difficulties, distinctive physical traits, and certain health concerns.
>This additional genetic copy raises gene activity above normal levels. It pushes cells to overwork, because they carry extra material that shifts how genes are used and how proteins are made.
>CRISPR-Cas9 is a versatile gene-editing system that relies on an enzyme to recognize specific DNA sequences. Once the enzyme locates a matching site, it snips through the DNA strands.
>Scientists carefully design CRISPR guides to target only the unwanted chromosome. This trick is called allele-specific editing, and it helps steer the cutting enzyme to the right spot.
>“Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells,” wrote Hashizume.
>Their group discovered that removing the unneeded copy often normalized gene expression in laboratory-grown cells.
>The treated cells reverted to typical patterns of protein manufacturing. >They also showed better survival rates in certain tests, indicating that the excess genetic burden was successfully relieved.
https://www.earth.com/news/crispr-used-to-remove-extra-chromosomes-in-down-syndrome-and-restore-cell-function/
>Recent work points to a promising approach with CRISPR-based methods.
>Ryotaro Hashizume and colleagues from Mie University in Japan report that it is possible to cut away the surplus chromosome in affected cells, which appears to bring their behavior closer to typical function.
>Down syndrome affects about 1 in 700 newborns in the United States. That added chromosome, known as trisomy 21, disrupts a range of important processes in the body, often resulting in learning difficulties, distinctive physical traits, and certain health concerns.
>This additional genetic copy raises gene activity above normal levels. It pushes cells to overwork, because they carry extra material that shifts how genes are used and how proteins are made.
>CRISPR-Cas9 is a versatile gene-editing system that relies on an enzyme to recognize specific DNA sequences. Once the enzyme locates a matching site, it snips through the DNA strands.
>Scientists carefully design CRISPR guides to target only the unwanted chromosome. This trick is called allele-specific editing, and it helps steer the cutting enzyme to the right spot.
>“Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells,” wrote Hashizume.
>Their group discovered that removing the unneeded copy often normalized gene expression in laboratory-grown cells.
>The treated cells reverted to typical patterns of protein manufacturing. >They also showed better survival rates in certain tests, indicating that the excess genetic burden was successfully relieved.
https://www.earth.com/news/crispr-used-to-remove-extra-chromosomes-in-down-syndrome-and-restore-cell-function/
