>>510403508>time to eat some powder from alibabaDo whatever thrills you.
I'm not your momma.
CHITINASE ENZYME BULK.
Use these keywords and pick the dealer you have the most confidence in. Or don't do it at all if you prefer. That's why they call it FREEWILL.
Don't like FLYING BUGS?
Trehalose is the alcohol sugar form that powers insect flight. TrehalASE breaks trehalOSE into two glucose molecules.
Want to kill the flying bugs (plus mammal hibernators and cause problems for most birds)? TREHALOSE BLOCKERS.
Based on the search results, here are the key molecules that block trehalose metabolism, categorized by their mechanism of action:
I. Trehalase Inhibitors (block trehalose breakdown)
1. 5-Thiotrehalose
- Sulfur-modified trehalose analogue resistant to enzymatic degradation.
- Inhibits porcine trehalase (IC~50~ = 0.106 mM) and blocks trehalose utilization in Clostridioides difficile hypervirulent strains .
2. Mannotrehalose
- Epimer of trehalose (hydroxyl inversion at C2 position).
- Resists trehalase hydrolysis and inhibits porcine trehalase (IC~50~ = 1.132 mM) .
3. Lactotrehalose
- Epimer of trehalose (hydroxyl inversion at C4 position).
- Resists degradation by porcine trehalase but shows inconsistent inhibition in assays .
4. Validamycin A
- Known trehalase inhibitor but ineffective against C. difficile trehalose metabolism .
II. Trehalose-6-Phosphate Synthase (TPS) Inhibitors (block trehalose synthesis)
5. 4456dh
- Water-soluble derivative of SJ6675, identified via pharmacophore screening.
- Occupies the substrate-binding pocket of Tps1, suppressing trehalose synthesis in fungal pathogens (Candida, Cryptococcus). Causes loss of thermotolerance and fungicidal effects .
6. SJ6675
- Initial hit from the St. Jude pharmacophore library. Inhibits Tps1 enzymatic activity but optimized to 4456dh for solubility .