There are drugs that exist right now that are proven to make you smarter. Why don't you take them? Here's a list:
-TAK 653
>TAK-653 is a highly selective AMPA positive allosteric modulator that enhances cognitive function and mood
>makes information processing neurons more likely to fire. Normally when a neuron fires the other neurons around it become primed too. With something like TAK, those other neurons would also be firing and then the neurons around that would be more sensitive
>one unique effect of AMPA PAMs is their ability to activate the precuneus in non-human primates, a brain region typically dormant during wakefulness
>the precuneus plays a key role in episodic memory, self-referential thinking, and consciousness
>TAK-653 has shown improvements in executive function, working memory, and cognitive flexibility, without the seizure risk associated with less selective compounds
>also being investigated for treatment-resistant depression, producing ketamine-like antidepressant effects without impairing cognition

https://www.reddit.com/r/NooTopics/s/r78FCkc3kw

All the substances I will list out can be bought at everychem.com

>AF710B is a dual-action cognitive enhancer targeting both M1 muscarinic receptors and Sigma1 receptors
>M1 activation is one of the few pathways repeatedly shown to enhance cognition in healthy people
>clinical trials with M1 ligands (VU319, HTL0018318) showed high effect sizes on attention, memory, and learning
M1 acts on the dorsolateral prefrontal cortex, modulating delay cell activity for working memory via calcium and cAMP signaling
>AF710B binds the M1-Sigma1 complex, enhancing M1 allosterism at much lower doses than traditional agonists
>this dual binding drastically increases ERK-driven long-term potentiation (LTP, memory formation) without affecting long-term depression (LTD)
>preclinical studies showed 1500% amplification of LTP via acetylcholine at this receptor complex
>in rodent models, AF710B improved working memory and spatial learning beyond baseline, even outperforming healthy controls
benefits were sustained 5 weeks post-treatment, and were dependent on Sigma1 activity, confirming synergy between both targets
>Sigma1’s role as a chaperone receptor further enhances regional neuroplasticity and memory consolidation, but human data is still limited
>AF710B completed Phase 1 trials with high safety and tolerability, and is now in Phase 2 for schizophrenia
https://www.reddit.com/r/NooTopics/s/RhSsuWoLYC

>ACD856 is a selective TrkB positive allosteric modulator (PAM) and enhances signaling of neurotrophic factors like BDNF and NGF by increasing binding at TrkA, TrkB, and TrkC receptors
>Mechanism overlaps with many antidepressants and psychedelics, which also act as TrkB PAMs (e.g., psilocin, LSD, ketamine metabolite, fluoxetine)
>Supports the theory that TrkB/BDNF activation underlies antidepressant and plasticity effects
>ACD856 may enhance cognition similarly to AMPA PAMs like TAK-653, due to shared downstream effects involving BDNF and mTOR
>In animal studies, ACD856 reversed cognitive deficits induced by NMDA antagonists (MK-801), indicating potential neuroprotective and procognitive effects
>Also shown to increase endogenous BDNF in a possible feed-forward mechanism
>Passes early clinical trials with good pharmacokinetics and no significant side effects; 20-hour half-life improves over ACD855’s impractical 68-day half-life
>ACD856 can potentiate other BDNF-linked compounds, making it a strong candidate for stacking

https://www.reddit.com/r/NooTopics/s/jcDFco1IyN

>>510731423

>Usmarapride is a 5-HT4 partial agonist, structurally related to Prucalopride but designed for CNS selectivity to avoid peripheral side effects
>Demonstrated improvements in hippocampus-dependent memory in healthy humans in tasks like RAVLT and PILT
>Likely promotes BDNF release in the hippocampus, contributing to its antidepressant and anxiolytic effects
>Combination of Usmarapride and ACD856 shows strong synergy
>Usmarapride increases BDNF, while ACD856 amplifies BDNF activity via TrkB modulation
>This dual mechanism may enhance memory, neuroplasticity, mood, and resilience to stress
>Safety profile of both compounds is acceptable at tested doses; some users reported headaches with higher doses of Usmarapride
>The stack represents a novel nootropic strategy leveraging BDNF and TrkB signaling for cognitive enhancement and neuroprotection
https://www.reddit.com/r/NooTopics/s/4vuCLZU6U2

white people are junkies by nature

you don't need drugs for that though

>>510731549
Latinx beaners are junkies for calories which is arguably more destructive than drugs

Because I don't want to be a free lab rat?

>lookup videos about tak-653
>some tranny vtuber video comes first

>>510731106 (OP)
>There are drugs that exist right now that are proven to make you smarter
Yea, it's called microdosing lsd.

>>510731106 (OP)
If I'm smart I'm smart If I'm dumb I'm dumb, but I won't take enhancers either way. I am what god or nature decided me to be, and I'm happy with that

>>510732816
mexican andy

>>510731106 (OP)
Yeah it's called looking at a picture of a cute nerdy redhead.
(As a while virgin male)

also mämmi ja piimä, extremely potent substances for higher IQ

The deep satisfaction derived from feeling like you are enough while you see people around you doing shit like this. Feels good man.

>>510734473
Do you also get deep satisfaction for posting the same comment multiple times thinking your opinion matters?

>>510733930
*white virgin male.
... yeah I know this comment is not living up to the fact this works. but my life is proof of that so...

>>510731106 (OP)
WHAT'S YOUR IQ BEFORE/AFTER YOU CONSUMED TAK-653, AF710B, ACD856 AND Usmarapride? HOW DO YOU PERFORM ON COGNITIVE TESTS? HOW HAS YOUR CORTICAL STRUCTURE CHANGED? WHERE ARE YOU ON THE VAS? WHAT SIDE EFFECTS HAVE YOU NOTICED WHILE TRACKING YOUR DRUG LEVELS AND BLOOD/PLASMA?

>>510731106 (OP)
>wanting to be smarter

>reddit

>>510731106 (OP)
Or you could, you know, just read a book?

>>510734852
This

>>510734605
Saame thread, same response. Pot, kettle.

>>510731106 (OP)
by the way you describe it, it sounds like it would have the long-term side effect of destroying either your memory or your ability to reason.

Note that what you're describing are drugs which encourage neighboring neurons to fire. But the reason that's an advantage is because those synapses were joined via the proper functioning and reasoning of the brain.

My question is this... if a person starts to spend a majority of their time on drugs which cause an abnormally high firing of adjoining neurons; how long before they can't fire normally without the drug? And more importantly... will this create a side effect that new synopses/memory are now created based on flawed (over-stimulated) processes which are less accurate.

For example.. when a retailer has too many sales. A company having a sale for the first time is a big deal, and everyone wants to buy at a discount. But if the same retailer has a "sale" every day; over time that "sale" price becomes the new everyday price.

>>510731106 (OP)
Thanks so much! I've been working on creating healing synergistic stacks for mental optimization and these may be near groundbreaking additions. Still doing the research, but, wow, thanks again, these look very helpful!

>>510731106 (OP)
>Why don't you take them?
because I'm not a nigger, I don't do drugs

>>510736503
With the BDNF-stimulation and neuroplasticity, it would make the benefits slightly permanent. Depends how long you take it for, but its not just boosting cognition, it is solidifying the changes.

You will want to cycle pretty much anything to prevent tolerance and desensitization of neurons. Usually 5 days on, 2 days off is a good way to do it so you get the benefits but don't run the risk of temporary desensitization.

>>510731106 (OP)
>>510731242
>>510731423
>>510731484
How many of these are penny stocks?

>>510736503
Nootropics sound potentially useful, but the long term health effects are worrisome. I doubt that any of them have enough research or long term use to know how they will affect you in the long term.
The exceptions being caffeine and nicotine.

>>510731106 (OP)
>>510731242
>>510731242
>>510731423
>>510731484
All this shit will fuck up your heart as side effect, like most drugs do.