There are drugs that exist right now that are proven to make you smarter. Why don't you take them? Here's a list:
-TAK 653
>TAK-653 is a highly selective AMPA positive allosteric modulator that enhances cognitive function and mood
>makes information processing neurons more likely to fire. Normally when a neuron fires the other neurons around it become primed too. With something like TAK, those other neurons would also be firing and then the neurons around that would be more sensitive
>one unique effect of AMPA PAMs is their ability to activate the precuneus in non-human primates, a brain region typically dormant during wakefulness
>the precuneus plays a key role in episodic memory, self-referential thinking, and consciousness
>TAK-653 has shown improvements in executive function, working memory, and cognitive flexibility, without the seizure risk associated with less selective compounds
>also being investigated for treatment-resistant depression, producing ketamine-like antidepressant effects without impairing cognition

https://www.reddit.com/r/NooTopics/s/r78FCkc3kw

All the substances I will list out can be bought at everychem.com

>AF710B is a dual-action cognitive enhancer targeting both M1 muscarinic receptors and Sigma1 receptors
>M1 activation is one of the few pathways repeatedly shown to enhance cognition in healthy people
>clinical trials with M1 ligands (VU319, HTL0018318) showed high effect sizes on attention, memory, and learning
>M1 acts on the dorsolateral prefrontal cortex, modulating delay cell activity for working memory via calcium and cAMP signaling
>AF710B binds the M1-Sigma1 complex, enhancing M1 allosterism at much lower doses than traditional agonists
>this dual binding drastically increases ERK-driven long-term potentiation (LTP, memory formation) without affecting long-term depression (LTD)
>preclinical studies showed 1500% amplification of LTP via acetylcholine at this receptor complex
>in rodent models, AF710B improved working memory and spatial learning beyond baseline, even outperforming healthy controls
>benefits were sustained 5 weeks post-treatment, and were dependent on Sigma1 activity, confirming synergy between both targets
>Sigma1’s role as a chaperone receptor further enhances regional neuroplasticity and memory consolidation, but human data is still limited
>AF710B completed Phase 1 trials with high safety and tolerability, and is now in Phase 2 for schizophrenia
https://www.reddit.com/r/NooTopics/s/RhSsuWoLYC

you should click on that reddit link and stay there

>ACD856 is a selective TrkB positive allosteric modulator (PAM) and enhances signaling of neurotrophic factors like BDNF and NGF by increasing binding at TrkA, TrkB, and TrkC receptors
>Mechanism overlaps with many antidepressants and psychedelics, which also act as TrkB PAMs (e.g., psilocin, LSD, ketamine metabolite, fluoxetine)
>Supports the theory that TrkB/BDNF activation underlies antidepressant and plasticity effects
>ACD856 may enhance cognition similarly to AMPA PAMs like TAK-653, due to shared downstream effects involving BDNF and mTOR
>In animal studies, ACD856 reversed cognitive deficits induced by NMDA antagonists (MK-801), indicating potential neuroprotective and procognitive effects
>Also shown to increase endogenous BDNF in a possible feed-forward mechanism
>Passes early clinical trials with good pharmacokinetics and no significant side effects; 20-hour half-life improves over ACD855’s impractical 68-day half-life
>ACD856 can potentiate other BDNF-linked compounds, making it a strong candidate for stacking

https://www.reddit.com/r/NooTopics/s/jcDFco1IyN

>Usmarapride is a 5-HT4 partial agonist, structurally related to Prucalopride but designed for CNS selectivity to avoid peripheral side effects
>Demonstrated improvements in hippocampus-dependent memory in healthy humans in tasks like RAVLT and PILT
>Likely promotes BDNF release in the hippocampus, contributing to its antidepressant and anxiolytic effects
>Combination of Usmarapride and ACD856 shows strong synergy
>Usmarapride increases BDNF, while ACD856 amplifies BDNF activity via TrkB modulation
>This dual mechanism may enhance memory, neuroplasticity, mood, and resilience to stress
>Safety profile of both compounds is acceptable at tested doses; some users reported headaches with higher doses of Usmarapride
>The stack represents a novel nootropic strategy leveraging BDNF and TrkB signaling for cognitive enhancement and neuroprotection
https://www.reddit.com/r/NooTopics/s/4vuCLZU6U2

>>510868361 (OP)
>take this placebo or experimental chemical and you'll become 200iq
try deferoxamine, some schizo on /sci/ claimed iron accumulation in the brain was the reason for cognitive decline
https://warosu.org/sci/?task=search&ghost=false&search_text=deferoxamine
guessing he died

im already getting ritalin from my doc for free, why should i pay for other stimulants? how much do those nootropics even cost?

>>510869398
They average out to around $30 for a months worth

>>510869885
hmm. sounds interesting then. especially that one that increases neuroplasticity

>>510868361 (OP)
Right but how do I buy these safely and how do I verify that i'm getting what they say they're giving me.
Are there proper dosing guides?

Is nootropics why the average redditor is so much smarter than the retards on 4chan?

>>510868361 (OP)
I'm already smart enough. Intellect becomes excess after a certain point, when you don't have the resources, influence or priorities to utilise it. We don't know if these drugs are gonna fuck with you somehow down the line.

Another pied piper campaign to get people to take crazy shit that damages their health

what would the dosage be then? i’m not finding any reference of it

>>510870618
It's the IQ bellcurve. Reddit represents the middle of the curve, while 4chan represents both ends.

I'm not gonna spend hundreds of dollars on drugs that will give me a placebo at best. Fuck you Big Pharma shills.

>>510868361 (OP)
On today's episode of anything and everything except eating clean, training hard, and sleeping well.

>>510870549
You can buy them from everychem.com
There is a guy/company called Janoshik that you can send your drugs in to get tested to verify the identity and purity of the drug, and make sure there's no undisclosed chemicals in it
You can find dosing guides on the subreddit i linked at the bottom of the op
>>510871049
Search on the nootopics subreddit and you'll find the dosing