>Robots counter The Game (hacking/aimbot)
>Parasites counter Nature
>Demons (at least Demon Lord level) counter Parasites (we see Jachi's natural mana, even while suppressed, kill nearby weaker lifeforms)
>The Curse counters both Nature and The World Tree (it eradicated all life in its original world)
>Aliens counter Robots (we've already seen them take out satellites and the Robot mothership is in orbit)
>The Game counters The Neo-Humans (Neo-humans are obsessed with entertainment and The Game is all about being highly addictive and impossible to win)
Pretty much everything else is just "who can hit each other harder".