Do you need to apply tretinoin every single night to maintain? I've been using tretinoin 0.05% since august 2nd. I started out using it three times a week, then I moved to four times a week and two weeks ago I added in a fifth day and it caused the skin on my chin get wrinkled, red flaky and sting. I asked on reddit and they said you have to use tret every night and you can only use it 3 times a week after a year to maintain. I started using it every night 5 days ago and I have tons of acne on my lip area