Anonymous
7/11/2025, 9:32:28 AM
No.76364033
>>76361205
most lipid lowering drugs have failed in controlled trials. From cetp inhibitors to fibrates to niacin to pcsk9 inhibitors to cholestyramine to ezetimibe. Statins are the exception due to pleiotropic effects on coagulopathy and inflammation not cholesterol lowering. MR studies do not show causation and have myriad issues
https://pubmed.ncbi.nlm.nih.gov/30198808/
most lipid lowering drugs have failed in controlled trials. From cetp inhibitors to fibrates to niacin to pcsk9 inhibitors to cholestyramine to ezetimibe. Statins are the exception due to pleiotropic effects on coagulopathy and inflammation not cholesterol lowering. MR studies do not show causation and have myriad issues
https://pubmed.ncbi.nlm.nih.gov/30198808/