>>717012889
It is a balance. If you aren't picking up new things, you will miss a lot. Only found my way through a couple areas because I was following the breadcrumbs of unlooted crap lying around.
On the other hand, by the end of the game I had huge amounts of many materials to the point where I had medium chests of just one or two types of item and my game lagged pretty hard when using the item pad.
If only I was a guncuck I would've had a use for all that paper and metal scrap.