Male oocytes from alternate spermatogonium differentiation ?

>>16700226 (OP)
Bro is speaking enchantment table[math]\unicode{x1F480}[/math]

>>16700226 (OP)
Double sperm cloning?

>>16700226 (OP)
Not sure what you're exactly asking. Are you asking what would happen if a spermatogonium was transdifferentiated (perhaps using iPSC technology) into an oocyte then fertilized with a sperm from the same person?

Well I have the answer for a situation similar to this which does actually happen in nature often and it's called molar pregnancy.

How does this happen? sometimes females ovulate empty ova that contain no genetic material, and these ova sometimes get fertilized by two sperms (or one sperm that undergoes duplication), resulting in an ovum containing entirely male genetic material. The outcome of this? a molar pregnancy, specifically a complete hydatidiform mole.

Complete hydatidiform moles contain only placental tissue and no fetal tissue, they can also develop into cancer of the placenta known as choriocarcinoma.

>>16700243
i meant spermatogonium was ARTIFICIALLY transdifferentiated into an oocyte .
In other words i meant picking an spermatogonium and in black box environment emulating an ovarian transdifferentiate it into a functional oocyte

>>16700254
Well such an oocyte would be different because it could contain a Y chromosome unlike a natural oocyte. If such an oocyte gets fertilized by a sperm bearing a Y chromosome then it would result in 46, YY genome containing no X chromosomes, which is incompatible with life.
But other than this possibility the other possibilities are 46, XY and 46, XX. Whether these would result in a viable pregnancy would depend if genes were imprinted correctly. If you're unfamiliar with genomic imprinting see https://en.wikipedia.org/wiki/Genomic_imprinting

I'm not sure if transdifferentiation would cause genes to remain the same or get imprinted correctly. The former case would result in complete H. mole or a miscarriage.

The problem with chromosomes from a single parent is that it would result in uniparental disomies, specifically isodisomies which cause imprinting disorders such as Prader-Willi or Angelman syndrome and many others.

So the answer is it depends on the process of transdifferentiation and whether it allows correct imprinting of genes. There's also the possibility of getting autosomal recessive diseases because you're taking alleles from the same parent.

>>16700268
1 Spermatogoniums do not have imprinting.
2 the sperm would be from another male.

>>16700269
Then genetically it would be the same as two sperms fertilizing an empty ovum, i.e. a complete H. mole.
There, you have your answer.

>>16700273
no because that has male imprinting!

>>16700279
Do understand what imprinting is? it means that certain genes get disabled depending on the parent, that is some genes are only active from paternal chromosomes, while some are only active from the maternal chromosomes.
Two sperms, even from different persons, will have the same pattern of male imprinting and thus the same genes disabled on the same loci and so it would result in deficiencies of these genes resulting in imprinting disorders.

Having paternal uniparental disomy across all chromosomes would be a disaster and is actually exactly what happens in the case of a complete H. mole.

>>16700287
That imprinting results from differentiation , what are you talking about.

>>16700292
No? Imprinting happens before meiosis, not after fertilization.

>>16700297
exactly , thats why i would spermatogonium!

Tranny thread DNI

>>16700300
Ah, in that case, if you turn a spermatogonium into an oogonium then let it differentiate into an ovum then it would have the correct *female* pattern of imprinting which should theoretically result in a viable fetus if fertilized with a sperm (except for the case of 46, YY of course).

>>16700303
>n that case, if you turn a spermatogonium into an oogonium then let it differentiate into an ovum then it would have the correct *female* pattern of imprinting which should theoretically result in a viable fetus if fertilized with a sperm (except for the case of 46, YY of course).

Thats what i meant, i just wanted to know if anyone is also grinding it

>>16700304
Well, there are many technical difficulties associated with this but *theoretically* it should be possible, emphasis on the word theoretically.
Perhaps an easier method would be using nuclear transfer by removing the nucleus of a developing oogonium then injecting the nucleus of a diploid spermatogonium to produce an ovum from a male genome.

>>16700311
AGI era is here dude, no need for shortcuts.
what is you're skills set btw?

>>16700315
I'm just a medical student. I also have interests in math, physics and biochemistry. I don't have any practical skills yet.

>>16700226 (OP)
>>16700243
>>16700254
>>16700268
Samfagging troon

>>16700316
Do you know any medical/biochemical forum where i can discuss this ?

>>16700332
Unfortunately, no. If I knew a better place I wouldn't be here.

>what would happen
>nothing
>death
>cancer
This checks out. This has been the /sci/ troon thread, out.