Thread 16721907

managed to reverse cognitive decline that comes with age due death of neurons?

>>16721907 (OP)
death to neurons is inevitable lmao
he will have to iq test himself once a year over many decades to record a non progressive cognitive decline amount vs public data

He looks so much worse than he did prior to starting his life-lengthening endeavors.

Blueprint - How to spend millions of dollars to look like embalmed corpse.

>>16721956
it's the vegan diet
every vegan develops that same look

He looks lifeless. I once sent him an email after reading zero, telling him one of his supps is full of sugar, kek. Can‘t even do the most basic shit right, baka.

>>16722021
do jeets develop the same look?

>>16721907 (OP)
What does he look like, some kinda of autistic vanadium wizard?

He maybe barely gets enough Vitamin A from sweet potatoes.

>>16722092
>He maybe barely gets enough Vitamin A from sweet potatoes.
but that guy is high on accutane

>>16722073
jeets ain't vegan nigga

>>16722108
they're, especially the higher caste hindpoo fags

>>16721907 (OP)
Contrary to the popular belief, neurones don’t die in any significant number through your life unless you have a medical condition or brain damage

>>16722191
no. dairy is huge in the indian diet. they drink loads of milk, put cream in their curries and chicken marinades and eat cheese (paneer).

>>16721907 (OP)
this is badly outdated, your brain retains neuroplasticity until very very late in life and continue to form new neurons even in old age
>>16722300
this

>>16721956
How he looks doesn't equate to how long he could live, throw that nigga in a cryogenic chamber for centuries and he won't even age despite looking like a fucking ancient fossil because all his bodily functions are freezed

>>16721907 (OP)
Nope. Have you considered going to therapy to discuss about these feelings?

>>16722686
Pffft yeah not really
Old people are totally incapable of learning new things or changing their mind about anything even when presented with simple irrefutable proof
Its like theyre actually retarded. Have you ever seen an old person try to learn how to use a smartphone? It can take months just for them to remember how to get to the home screen by pressing the button at the bottom of the screen. Old people are literal fucking retards

The only thing that makes them capable of learning new things is taking psychedelics but luckily theyre so fucking retarded they'd refuse to do that because they think its just for degenerate pleasure like all other recreational drugs
But I guess if they took large doses it would often make them completely insane or even more retarded by unraveling their retarded old minds so quickly

>>16722774
Yeah hes actually going to die really young because hes a mentally ill retard who has ruined every aspect of his bodies homeostasis by taking thousands of pills

>>16721907 (OP)
If what he is doing was real he would not be telling people about it, he is telling people about it cause he is making money from doing so.

>>16722806
A lot of old people are pretty retarded, but there are way more psychoactive compounds than psychedelics out there; even liver and lobster are probably decent dementia-fighting foods due to their respective vitamin A and vanadium content.

I don't get why this is even a debate. Old people are slower. They can't learn new things easily. It's a fact of life.

>>16722882
>there are way more psychoactive compounds than psychedelics out there; even liver and lobster are probably decent dementia-fighting foods due to their respective vitamin A and vanadium content.
>vitamin a
>more psychoactive than LSD
what

>>16721907 (OP)
The incredible semicentennial man, he ages 2 years in 1 and turns more and more into a robot as he goes

>>16721907 (OP)
Why is his face yellow
Did he really do everything except putting on a damn sunscreen?

>>16722971
>Vitamin A and Alzheimer's disease
>https://pubmed.ncbi.nlm.nih.gov/22221326/

>The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer’s Disease in APPSwe/PS1dE9 Mice
>https://pmc.ncbi.nlm.nih.gov/articles/PMC7077345/

>>16721907 (OP)
To answer your question:
Does he look like a retarded poser?
If you did not answer yes to the question, you should probably get yourself checked for cognitive impairment.

>>16723201
You can only judge a book by its cover as deep as dermatology skills. His overall supplement game mogs his dermatology game; he's derpy at dermatology and kind of a high-tier midwit at other shit.

It's honestly remarkable how well his face has recovered from the adhesions caused by fat trooning sturgeries.

>>16723266
>>16723047
lol

the absolute state of seethe against this based chad who's going to outlive very freaking human in history by atleast 150+ years.

>>16723313
guarantee you he dies of some side effect of some experimental drug he took by age 70

>>16723314
I would laugh if he died of "natural causes" at some point in his 70s.

>>16721907 (OP)
I think he accelerated it

>>16723266
>you can only judge a book by its cover...
>ignores every component of the evaluation that has nothing to do with surface details
What he does.
How he does.
Why he does.
Etc etc.
Fucker actively pursues turning himself into a lolcow, and you doubt the evaluation?

>>16722774
>all his bodily functions are freezed
Being frozen is being dead.

Search BDNF

>>16721956
He's been at this for a couple years which isn't a huge amount of time. But yes, he looks like a convincing sculpture of a 35 year old made out of raw chicken.

I check up on his podcast and he seems smoother every time.

>>16723415
I dunno I want to look like that when I hit 60 too

>>16722818
and yet a lot of his information is verified by research. You’re retarded and projecting your own selfishness and cynicism. He’s literally measured for objective markers of aging, so he can’t just bullshit his way through it. Sure, he could be lying about his methods, but it’s not as if he’s telling people to do drugs and stay up all night

>>16722806
>Old people are totally incapable of learning new things or changing their mind about anything even when presented with simple irrefutable proof
It's not age, but a lack of intellectual effort. It's the same for the body: If you let it rot, you'll eventually get a rotten body. Also, you're probably underestimating the proportion of illiterate and quasi-illiterate among the general population, especially among elders.

>>16723746
Some of my former professors were old and yet quite sharp. Meanwhile, I know a few people younger than them with a very dull mind, because they passively consume instead of creating and learning new things.

Bryan Johnson is a hack

>>16721907 (OP)
Friendly reminder that he took it.

>>16721907 (OP)
>>16721925
Neurons don't die, they stop making neural connection

this guy is a ghoul but pretty funny sometimes, im glad some freaks like him are out there experimenting on themselves

>>16722806
That’s because the majority of old people are lifelong professional retards that wouldn’t read a book if you offered them a thousand dollars to do it. If you continue to use it you get smarter. Why do you think all novelists, philosophers, scientists, and artists generally make their best works as old men? The classic study that everyone refers to where neuroplasticity decreases after age 24 is a misinterpretation of data. It’s not that the study continued and they got dumber; they just ended the study because they lost funding for it.

>>16723898
>That’s because the majority of old people are lifelong professional retards that wouldn’t read a book if you offered them a thousand dollars to do it.
Why would you read a book for a thousand dollars? I'm not poor and I don't like to waste my time.

>>16723829
They die off nigga

>>16721907 (OP)
Has this guys autism actually contributed to our understanding of the aging process and is there another way I can learn about current research into it without podcasts or by manually looking through papers?
I found a masters program in germany "Genetics and Biology of Aging and Regeneration" but they don't have any recommended literature or online lectures.

>>16723898
>Why do you think all novelists, philosophers, scientists, and artists generally make their best works as old men?

This has never been the case most people make their greatest contributions by 30 years old. After that it's a slow decline.

>>16722191
>hindpoo fags
lmaooo

>>16721907 (OP)
He's a mormon that lost his faith and cant cope with the idea that there is no life after death so he has channeled all of his energy (and billions of dollars) to fight death. Its just religious neurosis he has to be a deeply unhappy person. If you read his daily routine my man has 0 joy in his life.

>>16725698
>there is no life after death
citation needed
>death
definition needed

>>16724885
>Has this guys autism actually contributed to our understanding of the aging process
He's a grift. The jenga tower is collapsing around him

>>16722806
>Old people are totally incapable of learning new things or changing their mind about anything even when presented with simple irrefutable proof
try having a conversation with a zoomer some time

>>16721907 (OP)
ok but why did he name his kid after the talmud

Seriously Johnson is a fucking hack you dont need to buy his shit to get anti aging info just have a chat with GPT this is the fucking future old man god i hate scammers

>>16722882
what's "old" I just turned 62 and replaced my AC compressor in my BMW yesterday then drove it 300 miles.

For me it's David Sinclair

he looks like shit.

>>16721907 (OP)
Clearly not.

>>16726412
>2025
>He can't even punctuate

>>16726412
>>16729457
Johnson and Sinclair and GPt all *kind of* know what they are doing but are also kind of hacks not doing much research. /fit/ is sharper with the small molecules than all of them these days >>>/fit/76414046

>>16721907 (OP)
He injects his son’s semen to look younger.

Not the ideal type of guy to get life advice from.

>>16721925
>>16722686 (dead wrong)
>>16723047
Cope. The loss of dopaminergic neurons is well documented as to are strategies to prevent it.

>The average age reductions across the DA system were 3.7–14.0% per decade.

By the time you are 40 you will be half as motivated as you were when you were 20. If you add alcohol and weed use you will be so stupid it isn't even funny and could barely be considered cognisant, which is why millennials, xers, and boomers are literally braindead and enjoy watching sportsball.

The use of selegiline prevents age related loss of dopamine by preventing the oxidative breakdown of it by MAO. If you are not on it, enjoy being a retarded old boomer in another decade or two with no rizz or motivation stuck waging away. Just research it and tell your doctor why you want it.

>>16732459
>Deprenyl (selegiline) inhibits MAO-B selectively in different animal species and in man. Its safety margin is remarkable. We were able to block MAO-B activity in the brain selectively in vivo in four species (mouse, rat, cat, dog) with s.c. administration of 0.17-0.31% of LD50. The usual oral dose range in clinical practice, 5-20 mg daily (0.05-0.2 mg/kg), is about ten times lower than the orally active dose in the rat. Deprenyl proved to be safe drug in man. Neither hypertensive reactions nor the need for any special dietary care were ever encountered during long-term (2-8 years) daily administration of the drug. The most important effect of deprenyl in the brain is the sensitization of dopaminergic neurons to physiological and pharmacological influences, but in contrast to levodopa or bromocrytine, deprenyl does not elicit an acute increase in dopaminergic activity. The effect of deprenyl is due, on the one hand, to the inhibition of MAO-B and, on the other hand, to inhibition of the uptake of dopamine. In agreement with its peculiar spectrum of pharmacological activity, deprenyl proved to be a useful adjuvant to levodopa alone or in combination with a peripheral decarboxylase inhibitor. In addition, a supplement of deprenyl in Parkinson's disease led to significant prolongation of the duration of the illness. This has not been observed so far with other antiparkinsonian drugs. The dopamine content of the human caudate nucleus decreases by 13% per decade over the age of 45. The hypothesis has been put forward that the significant increase of incidence of depression in the elderly, the age-dependent decline in male sexual vigour and the frequent appearance of parkinsonian symptoms in the later decades of life might be attributed to a decrease of dopamine and 'trace amines' in the brain. The possibility of countering these biochemical lesions of ageing by long-term administration of deprenyl, a selective inhibitor of MAO-B

>>16732461
The main problem is it upregulates MAO-A. The smartest strategy is to discontinue it every now and then, switching over to something like methylene blue.

>>16722073
Yes that’s why they’re all skinnyfat. Extremely high carbohydrate consumption and little to no meat will turn anyone into that eventually. North Indians also have been vegetarian for thousands of years so it’s become an epigenetic self-fulfilling prophecy. Even if a couple consumes a meat heavy ketogenic diet their children may still end up with the same shitty body

>>16722774
He’s not gonna see 70 with his diet, lack of sunlight, and chronic use of statins

>>16732459
you are entirely wrong, neuroplasticity is known to be retained into even advanced age even if not as incredible as in children
you chose to shift the topic to dopamine because you want to talk about your own little topic which is fine but you don't even understand your own post since
>>16732461
>The dopamine content of the human caudate nucleus decreases by 13% per decade over the age of 45
is not at all the same as the stuff you posted and has nothing to do with neuroplasticity

>Do These Two Cancer Drugs Have What It Takes to Beat Alzheimer’s?
>A new study finds FDA approved drugs that reverse the gene expression signatures associated with Alzheimer’s.
>letrozone and irinotecan
>https://www.ucsf.edu/news/2025/07/430386/do-these-two-cancer-drugs-have-what-it-takes-beat-alzheimers