THE DOCTOR IS FUCKING OUT! DO YOU HEAR ME! WHO THE FUCK DO YOU THINK I AM!

is 22lr enough to kill?
yes
is it enough for self defense?
no, and it's not reliable enough because it's rim fire

is 32acp enough to kill?
yes
is it enough for self defense?
no, not really

is 38 special enough to kill?
yes
is it enough for self defense?
yes
is a revolver a good idea in 2025?
no, move on

after combing through ballistics reports, 380 is the smallest practical self defense round that has the power and ballistics profile to put someone down fast enough. but if you are carrying something over 9mm, you are just being silly.