This is THE game to get fucked up to. I've played it high off alcohol, kratom, phenibut, ambien, dxm, gabapentin, weed, kava, propylhexedrine, and any combination of the above really. Definitely some more I'm forgetting too. The best is probably dxm and gabapentin/booze but those are my favorite drugs in general. I also ignore the soundtrack and just blast mostly 80's club bangers interspersed with some other favorites
https://www.youtube.com/watch?v=lI_8BHbauuQ
https://www.youtube.com/watch?v=c1GxjzHm5us
https://www.youtube.com/watch?v=NSkgEAvISL4
https://www.youtube.com/watch?v=E5i2Wa7daDA
https://www.youtube.com/watch?v=VrqTKG5WuXM
https://www.youtube.com/watch?v=AIgGOt534vY
https://www.youtube.com/watch?v=49qKb74AXe8
https://www.youtube.com/watch?v=z6wygmw2wPA
https://www.youtube.com/watch?v=EnUnL98eTxw