The best reason for Murdoch Murdoch to end was a change in message from the creator. Murdoch shifted away from a Kanye West "nigga heil hitler" format.
I do not see a future for Murdoch Murdoch without them using tranny cartoon art, embracing rule 34/pornography, and being unwatchable for older viewers.
A "new Murdoch" would simply be Hazbin Hotel with swastikas.