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6/5/2025, 9:37:29 PM
>>17739968
>Anon please do the math that I asked you to do. Do it your way. The way you're saying it should be done.
It's your proposal that it's a simple x*y calculation, which it isn't. I've explained why it's more complicated and is about allele frequencies, I'm beginning to suspect you don't understand what those are. That's not something you or I can calculate on the back on an envelope. How about YOU provide all the information of every single allele frequency in the region your talking about, and do your own calculation of these. Note, this is not "mutations*generations" in a "single lineage", I'm talking about allele frequencies and their change over time based on selection. Please provide them.
>This is not relevant. The math assumed the best case scenario for your position already: all mutations are kept, none are selected against and none are undone by a back mutation.
It's directly relevant. In a population, there are much, much more than 175 mutations per generation. So there are many more mutations, across the population, in the vestigal centromere and telomere sections than in your calculation (if it even deserves that name). Therefore, if they're selected for, the frequency of those mutations will increase with each generation. Each parent, on average, has multiple children. And these multiple lineages cross over, so a mutation becomes an allele that is selected for and increases its frequency *across the population*. If you don't understand, just say so, but if you just repeat "mutations multiplied by generations" I'll know you haven't understood.
>>17739959
I'll answer for that anon, even in just the part you linked to, it's nothing but repeats of the telomere sequence CCCTAA with some single base pair substitutions. QED
>Anon please do the math that I asked you to do. Do it your way. The way you're saying it should be done.
It's your proposal that it's a simple x*y calculation, which it isn't. I've explained why it's more complicated and is about allele frequencies, I'm beginning to suspect you don't understand what those are. That's not something you or I can calculate on the back on an envelope. How about YOU provide all the information of every single allele frequency in the region your talking about, and do your own calculation of these. Note, this is not "mutations*generations" in a "single lineage", I'm talking about allele frequencies and their change over time based on selection. Please provide them.
>This is not relevant. The math assumed the best case scenario for your position already: all mutations are kept, none are selected against and none are undone by a back mutation.
It's directly relevant. In a population, there are much, much more than 175 mutations per generation. So there are many more mutations, across the population, in the vestigal centromere and telomere sections than in your calculation (if it even deserves that name). Therefore, if they're selected for, the frequency of those mutations will increase with each generation. Each parent, on average, has multiple children. And these multiple lineages cross over, so a mutation becomes an allele that is selected for and increases its frequency *across the population*. If you don't understand, just say so, but if you just repeat "mutations multiplied by generations" I'll know you haven't understood.
>>17739959
I'll answer for that anon, even in just the part you linked to, it's nothing but repeats of the telomere sequence CCCTAA with some single base pair substitutions. QED
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