No.
I understand why would he get a mindbreak, but Homer holds no responsibility over Franks madness.
Its no ones fault that Franks life was absolutely shit and had to get the very little he has through sheer effort while Homer has almost everything he had through nepotism and being an impulsive fuck with iq on the two digits (and even with that its not like if Homer hasn't got his shit kicked in many times).
Frank just couldn't accept that.
And in no moment did Homer was malicious towards Frank in any way at all.