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Here’s a breakdown of the key hormones negatively affected by obesity, and how:

1. Insulin
Effect: Chronically high in obesity insulin resistance

Consequences:

Fat storage increases

Blood sugar dysregulation

Type 2 diabetes risk

Harder to lose fat

2. Leptin
Effect: Leptin levels are very high in obesity, but the brain becomes resistant to it

Consequences:

Constant hunger

Poor satiety signaling

Slowed metabolism (paradoxically)

Fat loss becomes harder

This is called leptin resistance—your body has plenty of leptin, but your brain "can't hear it."

3. Ghrelin (hunger hormone)
Effect: Ghrelin is often dysregulated

Consequences:

Hunger may not respond properly to meals

Cravings and snacking increase

Difficulty with appetite control

4. Testosterone (especially in men)
Effect: Lower in obese individuals

Consequences:

Reduced muscle mass and energy

Increased fat storage (especially visceral fat)

Low libido and motivation

Depression, fatigue

Fat tissue contains the enzyme aromatase, which converts testosterone into estrogen—worsening hormonal imbalance in men.

5. Estrogen (especially in men and postmenopausal women)
Effect: Higher than normal in obese men and postmenopausal women

Consequences:

Gynecomastia (in men)

Increased fat storage in hips/thighs (in women)

Hormonal imbalances in women (esp. PCOS-like symptoms)

6. Cortisol (stress hormone)
Effect: Chronically elevated or dysregulated

Consequences:

Increased belly fat

Muscle breakdown

Insulin resistance

Sleep problems, anxiety, depression