>>95711524
My favorite super settings are when it feels like there's several different genres and settings mashed into one. The alien is standing next to the sorcerer, who is standing to the WW2 solider, and so on. It lets you have the interesting points of conflict where characters might be extremely competent in their own wheel house, but now they are thrown out of the comfort zone and have to adapt. It also gives other characters their own natural time to shine. Thor's your guy if you need to fight a giant monster, but less so if you need to solve a mystery. This leans into the team aspect for supporting each other's strengths & weaknesses, and also makes the world feel like the heroes are constantly putting out fires.

Having said all that, making a setting like that actually work is a bitch and a half. In a long running campaign, players are going to want their characters to advance. So either you up the power level of the game, or characters broaden their skill base. That leads to never ending escalation of threats or a muddling of the contrasts between characters. Additionally, if you want to add that kind of depth to a setting, it can be hard to keep the details straight, or even to come up with them to begin with.