Slayer gloves are a piece of Slayer equipment used to fight fever spiders, and require a Slayer level of 42 to be worn. If the gloves are not equipped, the spiders will damage the player for 12.5% of their base hitpoints, as well as inflict disease. When worn, they resemble a lighter brown hue similar to that of normal leather gloves.

They can be purchased from any Slayer Master for 200 coins.