High science cost multipliers are especially tricky in space age, because you have to research electric mining drills. I'm doing 100x, so the first 2500 or so red science was crafted with ore mined from burner drills. I'm currently gunning for flame turrets, only picking up logistics and electric miners outside of the required techs for flame turrets so far. No car, no radar, no repair packs. Long term plan is to research Fulgora as quickly as possible, and then re-establish a base there for the bulk of the factory, since it has no military threats to worry about.