>>529012883
Shitty practices can and will still cause issues but it's not that much of an issue just by avoiding some older messes, half of which predate the CK itself. My currently oldest Skyrim save hovers around four years with 450ish hours of gameplay, all I had to do at some point was give the scripts a simple clean because of age but that's more about time spent than the mods. The longer you play and the more you have the bigger your saves will become, but it's a lot more important what's in them modwise than how big it is.