Dead Man

This movie is practically about the journey that your soul takes right after you die in order to detach itself from worldly detachments. The Indian co-protagonist is practically Johny Depp's spiritual guide in the afterlife, and the hitmen hired to kill him are the memories and demons that haunt us and try to keep us on this plane.
The scene with Iggy Pop is very strange.
At the end of the journey they end up among the Pacific Northwest Indians, who had a very interesting culture irl.