>>714236871
What do you mean 'little to no harm', it's quite literally in the name Extinction Entity.
There were 5 prior extinctions but they were nowhere near as bad as this one because the dominant species were not so advanced as Humans. Presumably it's just tiny voidouts that erupt around the EE instead of literally everyone having the potential to nuke cities into oblivion, invade our world as BTs and timefalling shit into oblivion. Even then, Cryptobioites are suggested to be able to thrive even when humanity is wiped out.
Because Amelie is smart enough as a human to try and R&D a way to survive the Death Stranding, she started all the BB experiments and creating the Chiral Network. She literally can't die/move on until all of humanity is dead so it doubles as a suicide trigger in DS1 until she decided to lock it and herself away due to Sam.