>>211889401
Not many.
I guess you could count Titania who was in that godawful She-Hulk show. Maybe some generic forgotten Skrull or Kree character...they could gender flip someone.
Really the only one I can think of who would be semi-original would be Frankie Raye (pic related) who's not so much a Fantastic Four villain as someone who thinks that Johnny Storm is fagging up the original Human Torch's good name, which is an entirely reasonable position.