Most of the time it feels like they just put two things onscreen at the same time and expect it to be intrinsically funny, like they're missing half the joke.
Trump trying to have gay sex with Satan is probably the funniest shit ever if you're balls deep in South park lore but otherwise "Trump is a degenerate faggot worse than Saddam Hussein except Saddam's cock wasn't so small only a 6 year old could feel it, ask my homie Jeffrey "might be true but isn't that funny. Maybe those are setting up a bigger joke and Satan's speech in episode 7 will be so memorable we'll talk about it for a decade but until then the pacing is shit and it feels like they're just introducing stuff without ever using it.