>>514867019
By facts?
>The Ashkenazi bottleneck refers to a significant reduction in the population size of Ashkenazi Jews, likely occurring between the 13th and 15th centuries in Europe. This demographic event resulted in a limited genetic pool, leading to increased frequencies of certain genetic traits and disorders among Ashkenazi descendants.
>Due to historical factors like persecution, migration, and isolated communities, the Ashkenazi population shrank to a small number, possibly a few hundred to a few thousand individuals. This "bottleneck" caused a founder effect, where the genetic makeup of the surviving population became the basis for future generations.
>As a result, certain recessive genetic mutations, such as those linked to Tay-Sachs, Gaucher’s, and BRCA-related cancers, became more prevalent due to inbreeding and limited genetic diversity.
>The bottleneck explains why Ashkenazi Jews, despite being a small global population (about 10-12 million today), have a distinct genetic profile and higher carrier rates for specific hereditary conditions compared to other populations.
