>>106580365
Yeah it's completely possible, you can set different font properties and overlays on the org elements, or create you own.
Oh wait actually, do you mean for each org document, like setting properties applicable only to the current org file? Im not sure on that one, it's probably doable but I haven't done it before. You can look at packages that make special org-mode modes that override the usual format. For example in doom theres doom-docs, and gptel also does it's own thing with the chat interface. Also I've seen some anons posting here with pretty stylized org docuemnts, like different font sizes and settings for headers, comments and the like.