I'm already in post-NES territory right now, but I got some homebrew which qualifies. Snuck into later system lists due to compatibility.

It is Tales of Popolon for any MSX with at least 16KB of RAM. A raycasted action-adventure game taking place in an evil fortress, the usual really. You get a main weapon to punch/stab creatures with an various secondary weapons that are powered by your god-o-meter. You'll find those in chests. Enemies generally walk up to you to try and hit you, but some enemies will also fire balls at you to actually force you to dodge.

It controls nicely, if a bit tanky. The one lever puzzle seems to have a set solution as you can get the same lever positions in other ways, but it won't open the grate. The gorgon is the only boss that does something different, in that it turns itself to stone and drops a snake before chasing after you again. The game itself is rather short, but iirc it was homebrew made for a contest.

It runs about as fast as you can expect from a regular MSX, but if you have a higher model (MSX2+ or Turbo R) you can pick a faster CPU mode or even a far smoother framerate (Turbo R only). You can also reduce the viewport size to help an original MSX along. The screenshots are the big size.