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In a interview with The A.V. Club, Animaniacs 2020 showrunner Gabe Swarr and executive producer Wellesley Wild tried answering that question by commenting on their approach for bringing back the wacky Warner trio, the difficulties of planning two years ahead since production began in 2018 and some of the cultural differences that surfaced in that 20 year gap since the show ended.
>One of the victims of this cultural paradigm shift was nurse Heloise Nerz (yes, she has a name), Yakko and Wakko’s crush and the blonde target for the brothers signature “Hellooo nurse!” catchphrase. As Swarr puts it, “immediately hello nurse was goodbye nurse”, noting that running gags like these simply wouldn’t work in 2020.
https://gamerant.com/animaniacs-hello-nurse-removed/amp/