Scion 2e is pretty good. 1e barely works as a game, and basically lacks a setting. 2e is more functional, more fun, broader, and generally more interesting. There isn't any reason for me to play 1e when it exists. 2e uses Storypath which is based on Chronicle of Darkness', which is based on oWoD, but it's a more pulpy actiony take on the whole thing. More bombastic and flexible, but with a fair few dials to tune that stuff. It's not amazing, and I don't think it's as good as CofD's, but it is still pretty solid and more functional overall than 1e. I don't really like how it handles movement, or health, and the rules writing can be jank but it's better than 1e

The setting is very different. Every religion is right, and them being correct is a fact of life. It's not crazy wacky supernatural shit 24/7 but it's present and people know about it. So no masquerade like in 1e, and you can basically do whatever you want with all of human mythology and it just kinda works. It's a setting that can be hard to grapple with if you really zoom in on any one thing but it does make for a evocative place to set a game in, which is generally more important. You could run a masquerade with but it's by no means the default

Like 1e the game itself is split across some main books, which all build on each other, for the various stages of a Scions power level. But now there are 4 of them. Origin, the first and core book, are on the level of extraordinary, but not obviously supernatural, humans. Although there are non-human options as well. The other books, Hero, Demigod, and God are the same deal as in 1e

Other supplements have some other stuff going on there too. Like options for Sorcerers to play as instead. Masks of the Mythos introduces a Lovecraft pantheon, Dragon has the characters be descendants of dragons that have their own place in The World, and there is a whole book on Arthurian myth and those sorts of stuff. Plenty of books, and more coming AFAIK, worth a read IMO