7-8 years ago I played big titty girls in Skyrim with nude mods and skimpy outfits, including first person mods that let you look down at cleavage. Used it to jerk off plenty of times. Almost a decade later, never once contemplated chopping my dick off or fucking myself up with hormones. The idea has 0 appeal.

I have no doubt some get pulled down that road as I've seen trannies post about how their pornified F:NV playthroughs were their 'awakening', but you need to have your brain already configured a certain way for that to happen.