Disease is a hurdle that an entire civilization is supposed to collectively overcome through the labors of genius within the realm of bioengineering and rigorous empirical science; it cannot be quantified and reduced into a petty paranormal punishment.
Enjoying the fruits of bounty and plenty, of having a good childhood, do not push your karmic scale towards evil. That is a matter of honor - it is your duty, to your forefathers and mothers, to continue that golden era and amplify it, to exponentiate the gifts you have been given into the maximum amount of gifts you are capable of producing for your children and loved friends.
Nothing was agreed upon as if some vindictive celestial council deliberates over each and every speck of soul. Randomization is miracle enough a thing that it should be sufficient answer.
What comes after depends on what came before, accordingly to the true experience of each unique entity. There are outlier events, but for the most part, death induces a state of timelessness, as the perception of time is a mortal phenomenon, the clockwork of ticking away atomic orbits altogether ceasing, and all of reality suddenly becoming an instantaneous conclusion. Within that pivotal moment of everythingness, you are confronted with the metaconstruct/God at the end of time that becomes the next beginning, the next localized big bang emission. This confrontation is an inescapable maelstrom of informing assessment, and it is from there humanity sources its subconscious primordial and inherent childlike whispers of knowledge. The ultimate purpose of that karmic equation remains in a superposition of suitable unknowability, for strict adherement to any one definition would be too constraining a thing thus betraying the obvious infinite freedom that is God. Should bad beings be suitably punished? Yes. Should good beings be suitably rewarded? Yes. A God being any other way would negate itself out of Godhood.
'pay it forward' and all that