I've been dreaming of running an rpg in the Enter the Gungeon world. It'd have to be a dungeon crawl with lots of loot, and having fun but simple combat with cute, varied enemies. I was thinking of retooling cyberpunk, but while it has tons of unique guns and an ammo economy, I don't know if the hit locations and complexity would work well.

What do you all think? Maybe simplifying RED, or is there a system I'm overlooking?