>>513960840
it was made in the 60s by some Pharma research group iirc and either used in large veterinary medicine or largely shelved for human use for a while until it became more common with hospitals in certain formats and for certain patients; effective in transdermal patches for example
it wasn't until then that criminal gangs started to produce it to replace the heroin market. not like this wasn't obvious to some people. William Leonard Pickard wrote in The Rose of Paracelsus and made a presentation in the 80s to a Harvard comittee about the impending pandemic of synthetic illicit opiods replacing plant derived opiates and the death toll it would bring, as well as its impossibility to control compared to poppy product before he dropped out and got arrested for making 95% of the world's LSD supply in an abandoned US missile silo.