>>713524906 (OP)First time? No mods. Only latest patch.
If you're still skeptic, grab the old "starter pack" modifications, namely the ZRP for some minor QOL improvements and fixes.
On second or so playthrough, go nuts.
I personally like AMK 1.4.1
Last thing: avoid the new "Enhanced Edition" de-masters. They fucked up and censored a shitton of content in those versions.