>>723860165 (OP)
The remake has some gameplay improvements with spot damage to enemies. IIRC it also balanced out weapons to make the Plasma Cutter less of an obvious stand-out choice, more like Dead Space 2 where most of them are pretty good as mains. It also has, obviously, higher detail graphics. There are some story changes that don't make a huge amount of sense.
The original has better lighting and area design; things like colour palette choices are more varied and logical. Although character models are less detailed, they do look better in terms of just overall face shape and such. The remake did VA face scans, to its detriment, and made a lot of the characters ugly.
The Necromorphs also look better in the original (in the remake, they look more like zombies that have been rotting in a grave for a while, whereas in the original, they look more like fresh corpses, which are both more disturbing, and more appropriate given that the outbreak was actually in its final stages when Isaac arrived, so most of the deaths would have been fairly recent).
I'd be inclined to recommend the original, regardless of whether you've played it before, but if the advantages mentioned in the remake seem worth it to you, you could go with the remake instead.