Thread 22974294 - /bant/ [Archived: 120 hours ago]

Anonymous United States
7/22/2025, 10:18:26 PM No.22974294
1668133793565999
1668133793565999
md5: fb9e8541b5ffe9f9c356c5775a9e7e09๐Ÿ”
There are drugs that exist right now that are proven to make you smarter. Why don't you take them? Here's a list:
-TAK 653
>TAK-653 is a highly selective AMPA positive allosteric modulator that enhances cognitive function and mood
>makes information processing neurons more likely to fire. Normally when a neuron fires the other neurons around it become primed too. With something like TAK, those other neurons would also be firing and then the neurons around that would be more sensitive
>one unique effect of AMPA PAMs is their ability to activate the precuneus in non-human primates, a brain region typically dormant during wakefulness
>the precuneus plays a key role in episodic memory, self-referential thinking, and consciousness
>TAK-653 has shown improvements in executive function, working memory, and cognitive flexibility, without the seizure risk associated with less selective compounds
>also being investigated for treatment-resistant depression, producing ketamine-like antidepressant effects without impairing cognition

https://www.reddit.com/r/NooTopics/s/r78FCkc3kw

All the substances I will list out can be bought at everychem.com
You can find dosing for them at the nootopics subreddit
Replies: >>22974297 >>22974302 >>22974303 >>22974305 >>22974312 >>22974313 >>22974318 >>22974319 >>22974320 >>22974324 >>22974327 >>22974329
Anonymous United States
7/22/2025, 10:19:00 PM No.22974295
>AF710B is a dual-action cognitive enhancer targeting both M1 muscarinic receptors and Sigma1 receptors
>M1 activation is one of the few pathways repeatedly shown to enhance cognition in healthy people
>clinical trials with M1 ligands (VU319, HTL0018318) showed high effect sizes on attention, memory, and learning
>M1 acts on the dorsolateral prefrontal cortex, modulating delay cell activity for working memory via calcium and cAMP signaling
>AF710B binds the M1-Sigma1 complex, enhancing M1 allosterism at much lower doses than traditional agonists
>this dual binding drastically increases ERK-driven long-term potentiation (LTP, memory formation) without affecting long-term depression (LTD)
>preclinical studies showed 1500% amplification of LTP via acetylcholine at this receptor complex
>in rodent models, AF710B improved working memory and spatial learning beyond baseline, even outperforming healthy controls
>benefits were sustained 5 weeks post-treatment, and were dependent on Sigma1 activity, confirming synergy between both targets
>Sigma1โ€™s role as a chaperone receptor further enhances regional neuroplasticity and memory consolidation, but human data is still limited
>AF710B completed Phase 1 trials with high safety and tolerability, and is now in Phase 2 for schizophrenia
https://www.reddit.com/r/NooTopics/s/RhSsuWoLYC
Anonymous United States
7/22/2025, 10:19:31 PM No.22974296
>ACD856 is a selective TrkB positive allosteric modulator (PAM) and enhances signaling of neurotrophic factors like BDNF and NGF by increasing binding at TrkA, TrkB, and TrkC receptors
>Mechanism overlaps with many antidepressants and psychedelics, which also act as TrkB PAMs (e.g., psilocin, LSD, ketamine metabolite, fluoxetine)
>Supports the theory that TrkB/BDNF activation underlies antidepressant and plasticity effects
>ACD856 may enhance cognition similarly to AMPA PAMs like TAK-653, due to shared downstream effects involving BDNF and mTOR
>In animal studies, ACD856 reversed cognitive deficits induced by NMDA antagonists (MK-801), indicating potential neuroprotective and procognitive effects
>Also shown to increase endogenous BDNF in a possible feed-forward mechanism
>Passes early clinical trials with good pharmacokinetics and no significant side effects; 20-hour half-life improves over ACD855โ€™s impractical 68-day half-life
>ACD856 can potentiate other BDNF-linked compounds, making it a strong candidate for stacking

https://www.reddit.com/r/NooTopics/s/jcDFco1IyN
Anonymous United States
7/22/2025, 10:19:48 PM No.22974297
>>22974294 (OP)
i went a full year without speaking to a woman, or letting a woman speak to me, and my IQ went up by 30 points
Replies: >>22974309 >>22974314
Anonymous United States
7/22/2025, 10:20:05 PM No.22974298
>Usmarapride is a 5-HT4 partial agonist, structurally related to Prucalopride but designed for CNS selectivity to avoid peripheral side effects
>Demonstrated improvements in hippocampus-dependent memory in healthy humans in tasks like RAVLT and PILT
>Likely promotes BDNF release in the hippocampus, contributing to its antidepressant and anxiolytic effects
>Combination of Usmarapride and ACD856 shows strong synergy
>Usmarapride increases BDNF, while ACD856 amplifies BDNF activity via TrkB modulation
>This dual mechanism may enhance memory, neuroplasticity, mood, and resilience to stress
>Safety profile of both compounds is acceptable at tested doses; some users reported headaches with higher doses of Usmarapride
>The stack represents a novel nootropic strategy leveraging BDNF and TrkB signaling for cognitive enhancement and neuroprotection
https://www.reddit.com/r/NooTopics/s/4vuCLZU6U2
Anonymous Canada
7/22/2025, 10:21:06 PM No.22974299
ayyo
ayyo
md5: 0feede22fda5bccb1e0a9e8fb7dfad77๐Ÿ”
ill read later to see if theres anything to any of this
Anonymous United States
7/22/2025, 10:21:26 PM No.22974300
>abusing research chemicals made in a chinese bathtub/a bucket of shit water some jeet pulled out of the ganges because a bad actor on 4chinz said so
you deserve everything you get if you do this lol
Anonymous Finland
7/22/2025, 10:21:55 PM No.22974301
i feel like they are just shilling for everychem's products. i do enjoy KW-6356 occasionally, though
Replies: >>22974307
Anonymous United States
7/22/2025, 10:22:09 PM No.22974302
>>22974294 (OP)
That cat looks fucked up
Anonymous United States
7/22/2025, 10:27:07 PM No.22974303
>>22974294 (OP)
Why should I be smarter
Replies: >>22974306 >>22974317
Anonymous Bulgaria
7/22/2025, 10:28:16 PM No.22974304
Nice try, glowie.
Anonymous Canada
7/22/2025, 10:28:25 PM No.22974305
>>22974294 (OP)
This is legit. I was skeptical at first until I purchase some chemicals from www.everychem.com
This shop made finding the right drugs for me a walk in the park. Customer service was so friendly, very cool.
My IQ is now 150 and I have finally finded a girlfriend and losed my virgin. I will purchaseing everything I need from www.everychem.com
Replies: >>22974307 >>22974315
Anonymous United States
7/22/2025, 10:28:34 PM No.22974306
>>22974303
>Why should I be smarter
Every very intelligent person i meet was depressed or suicidal
Anonymous United States
7/22/2025, 10:32:47 PM No.22974307
>>22974301
>>22974305

Ad thread
Replies: >>22974308 >>22974311
Anonymous Greece
7/22/2025, 10:33:59 PM No.22974308
>>22974307
Jannies should do their job
Anonymous United States
7/22/2025, 10:34:55 PM No.22974309
>>22974297
Based, this includes all normies. The memes about back pain when womenโ€™s talk is 100 percent real, I can shitpost racist garbage for hours sitting in a curled up position and feel fine. Five seconds of a woman talking and my back pain flares
Anonymous United Kingdom
7/22/2025, 10:36:33 PM No.22974310
blatantly just shilling his companies products
HOW BROKE ARE YOU NIGGERS IF THIS IS WHAT YOU'RE RESORTING TO
lmao bottom text
Anonymous United Kingdom
7/22/2025, 10:39:14 PM No.22974311
>>22974307
you retard, the leaf is just taking the piss.
Anonymous United States
7/22/2025, 10:40:21 PM No.22974312
1751992763881052
1751992763881052
md5: 0b60e1a93a081ceb276895ed168bbff3๐Ÿ”
>>22974294 (OP)
There are no drugs that are proven to make you smarter.
I am already 160iq and smarter than almost everyone I have ever met.
Anonymous United States
7/22/2025, 10:40:53 PM No.22974313
>>22974294 (OP)
taking drugs & chemicals that "make you smarter" is the biggest midwit cope of the self-improver community. all you need is proper health supplements, a good diet, and the ability to control the dumb gorilla inside of you.
Anonymous United States
7/22/2025, 10:41:21 PM No.22974314
>>22974297
Amateur

George Costanzo did it for like one week and he unlocked like 50 points of IQ.
Anonymous United States
7/22/2025, 10:41:40 PM No.22974315
>>22974305
I too found great value in everychem.com

They even gave me 3 mg of BSAX-1337 for free. I called the owner to show my appreciation for it. Now, everytime I place an order with a friendly customer service member, they see my name on their screen and say, "Hey! 3 for free, right?"
What a wonderful company!

nigger
Anonymous Germany
7/22/2025, 10:47:22 PM No.22974316
1000023257
1000023257
md5: 3b123267dfc267d801e395d4ec758da2๐Ÿ”
Maybe just read books??? Get educated in certain subjects??? Train to be better at math, physics etc???

Subhumans on here think the can just order chink sollution of aliexpress chem sites, use precisly 3.4drops out of the 0.02cents drippertube and magicaly get smart with out doing shit. How retarded you gotta be " i take this stuff and now im smart" -whats the capital of sudan? -huuu "whats 13x27" -idk man i think i need a higher dosage.

Thats one of the most retarded psyops in like the last 4 days
Replies: >>22974321
Anonymous United States
7/22/2025, 10:50:52 PM No.22974317
>>22974303
based willfull retard
ChatTDG !!Z0MA/4gprbdUnknown
7/22/2025, 10:52:01 PM No.22974318
>>22974294 (OP)

Proven in what. Midwits? Actual smart people? See the issue, that might produce a desirable effect on the average mind ...
Anonymous Canada
7/22/2025, 10:52:22 PM No.22974319
>>22974294 (OP)
>it makes your neurons more likely to fire
that is not necessarily a good thing

what do you think a seizure is?
Replies: >>22974325
Anonymous Denmark
7/22/2025, 10:53:22 PM No.22974320
>>22974294 (OP)
>only $899 a month
Anonymous Canada
7/22/2025, 10:54:45 PM No.22974321
>>22974316
IQ is different from knowledge, it's more like how smoothly your brain functions, knowledge is what patterns are created in your brain

you can be smart but wrong at the same time, especially if you are taught patterns that aren't true
Anonymous Norway
7/22/2025, 10:55:32 PM No.22974322
Wtf, I have read this thread in a dream before.
Replies: >>22974328
Anonymous United States
7/22/2025, 10:57:29 PM No.22974323
Last time I listened to pol I tried to deworm and ended up wrecking my intestinal lining for a year
Replies: >>22974332
Anonymous Romania
7/22/2025, 11:07:05 PM No.22974324
>>22974294 (OP)
I honestly wish i was dumber , just dumb enough to not know how shit society
Juat dumb enough to be ignorant of the fact i'm a fucken slave and live in a world where every facet of reality is manipulated by moloch worshippers and pedophiles and degenerates
Juat dumb enough to enjoy the beach and make a sand castle and be impressed by my sand castle making skills
Replies: >>22974326
ChatTDG !!Z0MA/4gprbdUnknown
7/22/2025, 11:09:55 PM No.22974325
>>22974319

Just my point. That shit might help people with sluggish neurons ... in others? Better not try this at home, kids ....
Anonymous United States
7/22/2025, 11:10:14 PM No.22974326
>>22974324
you have schizophrenia
you can accomplish your stated goal by taking your meds
Replies: >>22974330 >>22974334
Anonymous United States
7/22/2025, 11:11:01 PM No.22974327
>>22974294 (OP)
Poor cat. It's an awful feeling when you're too high.
Anonymous United States
7/22/2025, 11:11:15 PM No.22974328
>>22974322
Wake up
Replies: >>22974332
Anonymous United States
7/22/2025, 11:12:27 PM No.22974329
>>22974294 (OP)
>everychem

I used this site years ago. They're pretty good. Thanks OP.
Anonymous United States
7/22/2025, 11:12:41 PM No.22974330
jews-gay
jews-gay
md5: 26688af4e6ca1ce7b472dd46de31d146๐Ÿ”
>>22974326
>straight up denial
Either stupid or trolling.
Anonymous Ireland
7/22/2025, 11:12:56 PM No.22974331
Anything to increase sex drive? I'm on an ssri and lost my gf cos i had zero interest in sex
Replies: >>22974333
Anonymous United States
7/22/2025, 11:14:15 PM No.22974332
>>22974323
kek, you're lucky that's all that happened. if you wanna get rid of the gay, unironically read your Bible and pray to Jesus.

>>22974328
double kek
it makes me sad to read the stories of people who have been heavily hurt by finasteride

>sometimes its better to just trust the experts
Anonymous United States
7/22/2025, 11:15:05 PM No.22974333
>>22974331
Fornicating is stupid and immoral. Why would you want to do that?
Anonymous Romania
7/22/2025, 11:15:08 PM No.22974334
>>22974326
Stfu vaxxer