Thread 76596652

Bryan Johnson *vaguely* understands what he's doing, but the Blueprint protocol is lagging *pretty far* behind the latest anti-aging research. Here's new deranged China papers dropping recently that he isn't talking about yet...
>Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway
>https://journals.sagepub.com/doi/full/10.1177/09603271251371685
>Ferulic acid attenuates Sarcopenia progression by inhibiting peroxisomal ACOX1
>https://www.sciencedirect.com/science/article/abs/pii/S0891584925009037
>Phytochemical Screening and Anti-Ageing Potential of Herbal Extracts in A Topical Cream Formulation
>https://www.aktpublication.com/index.php/ijphdt/article/view/116
>Dingxin Recipe III Ameliorates Endothelial Cell Senescence in Atherosclerosis by Activating the FOXO3a/Pink1/Parkin Axis
>https://www.sciencedirect.com/science/article/pii/S0378874125012176
>Network pharmacology and bioinformatics analyses indicate a potential anti-aging effect of deferoxamine in mesenchymal stem cells
>https://link.springer.com/article/10.1007/s44337-025-00473-9
>Zuogui and Yougui pills extend lifespan and improve ageing biomarkers via kaempferol-mediated mitophagy in Caenorhabditis elegans
>https://link.springer.com/article/10.1007/s10522-025-10317-9
>Jingfang granule extends lifespan and healthspan in Caenorhabditis elegans: insights from RNA-seq analysis of genetic mechanisms
>https://link.springer.com/article/10.1007/s10522-025-10311-1
>Lipid-Lowering and Antioxidant Effects of Low-Sugar Fermented Clear Goji Berry Juice on Hyperlipidemic Caenorhabditis elegans
>https://www.sciopen.com/article/10.7506/spkx1002-6630-20250102-005
>Unveiling the anti-aging activities and mechanism of melibiose: insights from metabolomics and RT-qPCR analyses
>https://www.tandfonline.com/doi/abs/10.1080/10715762.2025.2551848
...anyone else on da PubMed molecule-mogging our favorite cryonics cuck?

Your memes haven't improved

>>76596708
Neither did your research skills.
>The tyrosine kinase inhibitor GNF-7 targets senescent cells through allosteric activation of GCN2
>https://www.biorxiv.org/content/10.1101/2025.08.29.673062v1.abstract
>Recombinant 30Kc19α-Lin28a fusion protein enhances mitochondrial function and attenuates senescence in human dermal fibroblasts
>https://link.springer.com/article/10.1007/s12257-025-00225-7
>A 28-Day Pilot Study of the Effects on Facial Skin Hydration, Elasticity, and Texture of a Centella asiatica Extracellular Vesicle-Based Skin Care Formulation
>https://www.mdpi.com/2079-9284/12/5/186
>Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers
>https://www.biorxiv.org/content/10.1101/2025.08.27.672709v1.abstract
>Interrogating the regulatory epigenome of cellular senescence
>https://link.springer.com/article/10.1007/s00018-025-05848-w
>Pilose antler peptide enhances diabetic fracture healing by modulating the CREB-Smad2/3-Runx2 signaling axis
>https://www.sciencedirect.com/science/article/abs/pii/S0378874125012061
>Yanghe Pingchuan granules inhibit cellular senescence in airway smooth muscle cells to improve bronchial asthma via modulating Nrf2 acetylation
>https://pmc.ncbi.nlm.nih.gov/articles/PMC12400603/
>Activity test cream anti aging extract ethanol 70% star fruits leaves (Averrhoa bilimbi l.) on skin new zealand rabbit backs exposed to UV-A light
>https://mail.shmpublisher.com/index.php/johmpe/article/view/542
>Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision
>https://www.biorxiv.org/content/10.1101/2025.08.30.673239v1.abstract
That last one kinda major... "These findings uncover a previously unrecognized protective axis driven by Yamanaka factors that circumvents reprogramming, providing therapeutic insights for age-related diseases."

The bot schizo is funnier than u

>>76596765
>The bot schizo is funnier than me
u said it bot bottom :D
>>76596920
>Upiór
it must be geolocked, otherwise u wouldn't use that bot

>>76596763
Since Schizo Yarmuckle factors work at least in part by downstream glutathione S-transferase-4 induction, here are some deranged China reverse network pharmacology hits on inducing that enzyme...
>Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
>https://www.tandfonline.com/doi/full/10.2147/DDDT.S68501#d1e171
>Saponins extracted by ultrasound from Zizyphus jujuba Mil var. spinosa leaves exert resistance to oxidative damage in Caenorhabditis elegans
>https://link.springer.com/article/10.1007/s11694-020-00653-4
>Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans
>https://onlinelibrary.wiley.com/doi/full/10.1155/2019/9012396
>In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum
>https://pubmed.ncbi.nlm.nih.gov/22380926/

>>76596708
that's just how it is on 4chan. no one will ever compliment your meme skill levels. at best they will simply ignore most of your painstaking work. but sometimes- just sometimes- one in a million, some retard takes it and just runs with it. then a whole bunch of retards start reposting it. then it's on tiktok and reddit and overnight it has spread all over the world and then finally years later it shows up on facebook. it's usually those half-assed throwaway memes that break through and spread like greek fire.

can you finish this one for me? i got bored halfway though. the premise is good though.

bump.

Happy to see this thread up again, keep at it, I appreciate you even if you're a bit abrasive sometimes
I also like your memes

>>76596652 (OP)
>>Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway
Interesting but unsure how that would work in vivo
>>Ferulic acid attenuates Sarcopenia progression by inhibiting peroxisomal ACOX1
Interesting, ACOX1 seems like a very general target though
>>Phytochemical Screening and Anti-Ageing Potential of Herbal Extracts in A Topical Cream Formulation
Worthless study
>>Dingxin Recipe III Ameliorates Endothelial Cell Senescence in Atherosclerosis by Activating the FOXO3a/Pink1/Parkin Axis
Interesting, very dense, will need to give it a good read later
>>Network pharmacology and bioinformatics analyses indicate a potential anti-aging effect of deferoxamine in mesenchymal stem cells
Far too preliminary but interesting
>>Zuogui and Yougui pills extend lifespan and improve ageing biomarkers via kaempferol-mediated mitophagy in Caenorhabditis elegans
Kind of interesting but flavonoids are a bit of a meme anyways
>>Jingfang granule extends lifespan and healthspan in Caenorhabditis elegans: insights from RNA-seq analysis of genetic mechanisms
Way too vague
>>Lipid-Lowering and Antioxidant Effects of Low-Sugar Fermented Clear Goji Berry Juice on Hyperlipidemic Caenorhabditis elegans
I don't know Chinese unfortunately
>>Unveiling the anti-aging activities and mechanism of melibiose: insights from metabolomics and RT-qPCR analyses
Seems pretty interesting but too vague and it's not on sci-hub

>>76598851
i check for a bryan johnson thread in the catalog almost every day. i fucking love these threads.

>>76596998
>Bryan Johnson sells a "Blueberry Nut Mix"
>He brags it has "Just 3 Ingredients: Macadamia nuts, walnuts, and blueberries."
>Nice ingredients, but It's hella overpriced
>Even normie purported "health food" stores like Whore Foods sell weirder tasty-ass fruits
>A really popular-ass one Bryan somehow doesn't know about turns out to be another Glutathione S-transferase enzyme family inducer and therefore *probable* downstream Yamanaka-log
>Açaí (Euterpe oleracea Mart.) Modulates Oxidative Stress Resistance in Caenorhabditis elegans by Direct and Indirect Mechanisms
>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089933

Got a hit on a really schizo-tier Schizo Yarmuckle factor analog plant doing more GST-family enzyme induction RNP...
>Mechanism of Longevity Extension of Caenorhabditis elegans Induced by Schizophyllum commune Fermented Supernatant With Added Radix Puerariae
>https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.847064/full
>Express levels of eight genes including daf-2, daf-16, sod-3, skn-1, gst-4, clk-1, age-1 and mev-1 were analyzed by RT-PCR method for possible C. elegan anti-aging mechanisms of SC-RP. Expression levels of key genes daf-2, gst-4 and sod-3 were up-regulated, while that of daf-16, skn-1, and clk-1 were down-regulated. The results suggest that SC-RP could extend the lifespan and healthspan of C. elegans significantly, and the IIS pathway, SKN-1/Nrf2 pathway and mitochondrial metabolism pathway were primarily considered associated.