>>40066267TL:DR there's no real risk of harm in doing it beyond the side effects of cypro (which aren't all that worrying in my opinion). If you can afford it and it will give you some comfort and assurance, I would do it.
Honestly, I don't claim to be an expert or anything, especially on stuff I haven't taken (EEn), but I don't really see any harm (beyond exposure to side effects of cypro) in taking cypro alongside a (near or at) monotherapy dose.
I've seen resources suggest 8mg Oral is a near monotherapy dosage (for anyone reading, don't try and mono oral, if nothing else it's the most expensive way to do HRT with no benefit over injections), but even if I went higher, I'd still stay on cypro for the assurance that my T is nuked to me personally, there's comfort in knowing that my T level is guaranteed to be gone that makes the cost/side effect risk of cypro acceptable.
With Cypro the sort of 2 side effect concerns I'd flag are
A) Effects on your cardiovascular system (this is mentioned on hrtcafe). This seems to be a prolonged use thing (talking over like multiple years), certainly not something I've experienced so far (I run a lot, and I've not seen any decline in my performance).
It's related to high prolactin (about 2x a normal level), but afaik this all goes away if you just stop taking cypro, should that become an issue.
B) It will lower your sex drive (like I only reach orgasm maybe once or twice a month), so if that's something important to you, just be aware. But also, this is an effect of pretty much all HRT to a greater or lesser extent.
There is no concern that it will negatively interact with EEn (or any other form of E) that I've seen written down anywhere when used with mono doses. It just does the same thing it does if you aren't on mono; the only difference is you may not need to be on it to block T.
