>>40341628T3 is scary, its an option of last resort but it all depends on how your dysphoria is and if you really need that muscle mass gone or not.
pio has some edema related risks that apply to everyone, but you can simply test for that at your ankles and discontinue for a while and you will be fine just like the countless other people that take it. most of the documented risks in pio are very obviously related to the poor health of the diabetics they used to give it to when it was a prescription diabetes med.