>>40450087>It's common knowledgeyawn
oral estradiol is completely metabolized by the liver. some estradiol is absorbed before going through the liver and make it into the bloodstream, it depends on the size of particles of the formulations (usually 5% absorption), pure estradiol has a short half-life (1-2 hours) and results in a short-lived peak. but oral estradiol doesnt rely on this, instead it relies on the metabolites of estradiol that can be reverted back, those metabolites have a much longer half-life and result in a extended effect that makes oral estradiol have a half-life of 13-20 hours
assuming that it is taken daily its as stable as injections, gels and patches