Thread 40750176

Previous >>40613841

• Help, advice, guidance on meds and dosages
• HRT related medical experiences and research
• Availability and pricing of medications
• Rational and scientific discussion

See following post for a pharmacy list.

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▶ Powers Method: https://powersfamilymedicine.com/s/Healthcare-of-the-Transgender-Patient-V60.pptx
▶ Endocrine Society Guidelines: https://academic.oup.com/jcem/article/102/11/3869/4157558
▶ Transline Guidelines (with bicalutamide): https://transline.zendesk.com/hc/en-us/article_attachments/360047702053/TransLine_HRT_Guidelines_FINAL.pdf
▶ WPATH SOC: https://www.wpath.org/publications/soc
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▶ Blood tests by mail: https://www.letsgetchecked.com/ DIY capillary blood samples. Expensive.
▶ Lab test guide: https://www.healthcare.uiowa.edu

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bump

I'm switching from DIY to an informed consent clinic.
I started taking HRT on March 31. My regimen was 12.5mg cypro every day and 2mg sublingual estradiol, which I bumped up to 4mg.
Now, I just got my prescription. It's 25mg spironolactone, also finasteride, and 6mg estradiol. He said I could take it sublingually if I wanted. He said twice a day, two pills in the morning and once at night; I asked if it was okay to just take one pill three times a day and that's fine too.
But isn't this kind of a weird regimen? I didn't think spiro was very effective at that low a dose? But 6mg sublingual E is also high enough to suppress T on its own, he said.
Is this a decent regimen?

>>40751621
Oh and I forgot to say he said to bump it up to 50mg after two weeks if my blood pressure was fine.

>>40750176 (OP)
Anybodh heard of b7-33 ? What is it supposed to do for mtfs ?

>>40751621
I don't think you're meant to take such a high dose sublingually. It absorbs better and you need about a 3rd of the oral dose you'd be taking.

>>40752521
So I should just take it orally?
And does that mean by 4mg sublingual has been too high?

I have been on a combination gels and patches for the past 18 months. Next month I'm swapping over to injections and starting prog. I'm fucking terrified.
Anyone have any guides for subq injections that will explain things to me step by step? Maybe some information on boofing prog?

i injected my brother last night while he slept.....

>>40751621
If that's 6mg as in 3x 2mg pills, that's probably OK.
The spironolactone dose is low, and the finasteride is usually only necessary in those with improper T suppression (some people with rare enzyme disorders might need it though). With that said, perhaps the higher E dose will compensate for the lower spiro dose.
Have you had your first blood test on the new regimen yet?

>>40752755
Thanks. No, I haven't had a blood test in the new regimen yet. I got a prescription on Thursday but have yet to go to the pharmacy to pick the pills up.
I'm supposed to get a blood test in about a month and a half and come in two weeks after that.

>>40752658
based

Is there any point in getting medical people involved at all? I'm doing undecylate and know I could never get something that convenient and cheap legitimately. Maybe I should get a therapist to just get it in writing that this stuff is going on, but I don't know how to get one and I'm intimidated.

>>40755568
>Is there any point in getting medical people involved at all?
Outside of phlebotomists to draw blood for blood tests?
No.

>>40755574
I've gotten my blood drawn doing quest and had good levels and while I felt really anxious getting it done, it was doable at least

i usually inject 0.075ml / 3mg of otokonoko's EEN per week but i'm going on holiday and it's easier for me to skip a week and do a larger dose to last 2 weeks instead. is it just as simple as doubling my dose or is there more to it?

>>40756385
Doing a 6mg dose before you leave would probably be sensible.
https://estrannai.se/#i0_cu,3,7,2-3,7,2-3,7,2-3,7,2-3,7,2-3,7,2-6,7,2-3,14,2-3,7,2-3,7,2-3,7,2-3,7,2_cu,3,7,2

Why do afab ftm fannybois even bother with testosterone if they're going to be weaker than real men anyway? I don't get it

>>40757447
Evidently AFABs on testosterone are going to be stronger than AFABs on estrogen.

>>40750176 (OP)
Does anyone know the dose for bicalutamide monotherapy? I've thought about adding estrogen but I quit hrt like 6 years ago and I'm not sure about going back on it. I basically just don't want to look more masculine or age anymore. I used to take 50 mg Bicalutamide with 6-8 mg of estrogen and now I'm just taking 150 mg Bicalutamide every three days. Should I change it to every two days? Should I be fine to block T effects? I wouldn't mind estrogen either but I also don't want to make myself look like a hon. I realize I ruined how I looked and could look. I just want to stay young looking for another decade or so if I can

18yo. Planning to start HRT. I've ordered EEn injections from AV, but should I do anything before.

A bit afraid of possible botched effects but I don't want T to effect me more

>>40759554
you can take up to 300mg/day, but the recommended dose is 150mg/day for monotherapy
bica monotherapy (assuming you have normal high T levels) is more or less HRT because your T gets blocked by bica, then it increases and turns into E at levels high enough for feminization to occur

does e2 level matter if your T is suppressed below cis female levels? been taking 3mg EV each week and T levels are below 20ng/dL and E at ~200pg/mL for 6 months now. should I up the dose or no?
i had "normal" hormone levels before starting btw

>>40759590
If you can get GNrH agonists or antagonists (expensive and may be hard to get), use them and start with a low dose of E, increase slowly. If not, E monotherapy is the second best option
Avoid using progesterone or any type of progestin (like CPA) during the first 4 years of HRT. But, if you need to use it, then go ahead
That's all

>>40760087
it doesnt matter, and you shouldnt increase the dose. youre actually benefiting from being in the normal range
dont rely on T levels alone to know if your T is fully suppressed. always test your LH and FSH in addition to T levels
also, this is expected considering that valerate has a short duration, and injecting once per week is considered long for it. your peak levels are probably much higher than your trough levels and may be responsible for the full suppression at relatively "low" levels

>>40760088
Agonists are too expensive to me, so ig EEn monotherapy is the way for me. Btw, is bica monotherapy a good way to suppress T?

Gonna take some blood tests soon, so maybe I'll be more aware what I should do

>>40760001
Thanks, I'll up my dose then. I've considered restarting hrt but I never really identified as a girl despite being on it for years. I was thinking about getting raloxifene. Is 60mg still the dose? Are serms injectible or am I better off just going back to estrogen?

>>40750176 (OP)
ive had consistenly below the 0th percentile hgh levels my entire life, how can i boost my levels to encourage chest growth? my growth plates are already fused

>>40760557
>Btw, is bica monotherapy a good way to suppress T?
not really. bica does suppress even high levels of androgens sufficiently, but it doesnt work the same way throughout the entire body. it has been found not to antagonize the effects of androgens on bones and muscles and may even act as an agonist in those tissues

>>40760587
I dont know much about SERMs, sorry

>>40760557
>>40760734
forgot to add. it doesnt work well to block androgens in the testicles, so youre more likely to maintain sperm production, fertility, etc. it also doesnt work well in the brain, so you retain androgen related effects there to some extent

>>40760144
>your peak levels are probably much higher than your trough levels and may be responsible for the full suppression at relatively "low" levels
i see, that makes sense.
guess its just a waiting game then? OP picrel example says to increase dose after a few months, but it uses AA with injections so who knows... i'm getting results as is, just not sure if it could be better ig.

im 3 weeks on E, very high dose 7mg of Een every week. still no visible breasts. is this normal? also is it real to do breast massaging for making the breasts even?

if i was a dht mutant would i have high sperm production despite t levels being suppressed

>>40761897
Do your nipples feel sore or nothing at all?

>>40762179
they hurt if touched, sometimes if fells like they are a bit more dense, sometimes seems like nothing changed. but im sure 100% they hurt

Does finastride help with bicalutamide when it comes to aromatizing t into estrogen or is there no reason to take it if I'm on bica?

>>40750176 (OP)
Been on HRT for almost a year and a half now and my levels keep getting lower every 3 months, even with me swapping from 1-2 patches. Went from ~180 pg/mL after the first few months (half patch first month, 1 following 2) and ultimately hit ~70 pg/mL at 1 year (on two 100mcg patches every 3-4 days). Shortly after I moved on to injections and started myself out at 8mg EEn IM every 8-9 days and that only got me to 102pg/mL at trough? I am still taking my cypro though I was planning on stopping them once I started injections initially. Started splitting my dose for every 4-5 days instead but is there any way to adjust my dose to something more reliable?

>>40762219
I’m in the same stage as you. I admit I am a bit impatient in term of growth but I’m sure growth will come soon if you are eating a good amount.

>>40750176 (OP)
Not sure if questions from FTMs will get answered here but I'm gonna try to ask anyways: I'm ordering a blood test soon since my providers only measure total T and never E, do I need to measure anything other than total T and estradiol levels? Not doing CBC, etc this time, just want to see the hormones.

Just recieved some confusing blood test results.

I was on 5mg EEn weekly and 12.5mg cypro every two days, my blood results were around 100 pg/ml E and 12 - 25 ng/dl T, pretty normal yeah? I wanted to switch to mono so I bumped my EEn dose up to 10mg, assuming that if 5mg gave me 100pg/ml, this would bring me to somewhere around 200pg/ml but no, I got this results (at trough of course) today.

434 pg/ml E
25 ng/dl T

???? weird, how do I move forward? shouldn't my T be wayyy more suppressed if my E is so high? I am still on cypro but still, how the fuck does 5mg weekly give me 100 pg/ml, but 10mg gives me THAT???? what should I lower my E dose to?

>>40762336
currently 21,2 bmi, i too planned to up my food intake. i will reach at least 24 to 25 bmi

>>40756428
thank you

if i were to get my E to levels typical for cis women while taking bica 50mg/day as an AA, would my T eventually lower from the initial spike to a point below baseline? looked into it lightly but most searchable posts are just reassuring that T spiking initially is expected behavior and then not much on what happens after. i figure T/DHT measurements from blood tests will be essentially useless while I'm on it but brief reading on the pharmacology wiki page says it only competently outcompetes DHT at high enough compared concentrations which causes some worry that typical E doses won't suppress T production enough to get there. I'm prob just overthinking it

>>40760734
is the bone agonist behavior a concern only w bica monotherapy? i figure everyone's just guessing when it comes to its behavior with HRT to an extent. im probably done growing but never hurts to hope lol. don't particularly want to do E monotherapy and bica seems the most manageable AA option.

>>40762543
You’ll be fine. It’s myself that I am slightly worried about in term of breast growth. But even if I don’t get too much at least it will be easier (because I am in Boymode)

>>40762120
no
in fact suppressing t should lower your dht levels a lot

>>40761897
>>40762336
if your nips are painful to touch then you're fine. you wont have boobs in just 3 weeks lol. it should become more visible after a few months

>>40762910
i'll also add to this that at first it just looks like puffy nips, but the rest should start to come in after a few months like i said.

>>40761335
you only have to increase your dose if your levels are really low, like below 100 pg/ml. you dont have to do anything with levels at 200 pg/ml. injecting more frequently (every 3 to 5 days) or switching to an E ester with a longer duration, aiming for 200 pg/ml again, is what you could do if you want to

>>40762312
you should be getting more stable levels now that you are on injections. transdermal E levels do vary a lot, and its normal for injections to give you levels much lower than you expected, especially if your E is DIY. you can also be more prone to getting lower levels due to fast E metabolism or something

>>40762532
>I bumped my EEn dose up to 10mg, assuming that if 5mg gave me 100pg/ml, this would bring me to somewhere around 200pg/ml
thats not how it works. your levels could increase exponentially with the increasing dose. use a simulator/graph to see what dose would make you hit 200 pg/ml
>shouldn't my T be wayyy more suppressed if my E is so high?
E by itself is good at suppressing T levels to below 50 ng/dl, but isnt good at suppressing them to below 25 ng/dl. for the first, you need on average 200 pg/ml, for the second, on average 500 pg/ml. do not rely solely on T levels to know if your T is fully suppressed, test your LH and FSH levels in addition to T levels
it does, however, look like your T is fully suppressed at 25 ng/dl, this low amount is likely not coming from the testicles

>>40763804
the problem is that the simulator hasn't been correct previously, on 5mg of EEn weekly I had 100 pg/ml, I think the next best course of action is to lower my EEn dosage to 6 or 7mg right? that should *probably* get me the levels I desire (somewhere around 200 pg/ml) also, I'm sure I'm being paranoid but if my T was the same at 5mg, lowering it to 6 from 10 shouldn't affect my T level at all right?

>>40762591
>if i were to get my E to levels typical for cis women while taking bica 50mg/day as an AA, would my T eventually lower from the initial spike to a point below baseline?
no, it would depend 100% on your E levels. your T levels remain stable after the spike from bica and would only be suppressed by E
the idea is that bica would protect you from the higher T levels
the dose recommendation for bica monotherapy is 150 mg/day. the dose for bicalutamide + fully suppressed testosterone (doesnt matter if it is from orchi, GnRH modulators or high E) is 25-50 mg/day. you would need a dose in between, but there is no actual dose recommendation for in between. when bicalutamide was being studied, the researchers made an arbitrary recommendation that bicalutamide levels should be 100 to 1000 times higher than androgen levels. if you follow those recommendations, you would get:
300mg = sufficient for up to 400-4000ng/dl of androgens
200mg = 300-3000ng/dl
150mg = 200-2000ng/dl
100mg = 150-1500ng/dl
50mg = 100-1000ng/dl
25mg = 50-500ng/dl
12.5mg = 25-250ng/dl
>is the bone agonist behavior a concern only w bica monotherapy?
no. any amount of bica can act as a partial agonist, but of course, the more you use, the worse the effects are. bica is okayish, if youre really worried about this, try to get GnRH modulators or an orchi, considering that you dont want to do E mono. other than those options bica is the best option

>>40763864
obviously, you cant just rely on the simulator. Im saying that doses and levels are not linear and simple. just lower your dose, and eventually, you will get to 200 pg/ml
>if my T was the same at 5mg, lowering it to 6 from 10 shouldn't affect my T level at all right?
it shouldnt, and yes youre being paranoid

>>40750176 (OP)
bump

I've been wanting to get away from taking t blockers as I know they're kinda hard on your liver and I probably shouldn't be on them because I smoke but I'm really afraid of needels. is it possible to do monotherapy with patches and is it worth asking my doctor about? also is monotherapy with sublingual estradiol pills better?

I'm about to run out of bica, considering just staying off it and going with mono EV injections, and I'm worried about a massive Tspike/masculinization

>>40765938
I don't think sublingual pills are better and I don't know about patches. I haven't been great with needles and it took me a while to finally do my first injection but after the first couple times its nothing

>>40766420
ok thanks for the advice. I've considered looking into an auto injector because I don't think I'll be able to stab myself.

>>40766524
I had the same problem. I tried jamming it in multiple times and stopped just before my skin
When I finally did it I was like "oh? that was it?"
regardless of pain, it is hard to get yourself to intentionally stab yourself with anything, but once you do it it becomes ez pz

>>40765938
T blockers are relatively safe, and the only way to know if your liver isnt affected by them is by trying and doing blood tests. it also depends on which AAs youre talking about
while intramuscular injections may be hard for you to do, subcutaneous injections are really easy. you almost dont feel anything if you use small syringes like insulin ones. even then, you can try other methods that may help you with injections, like autoinjectors. you could buy a single insulin syringe and do the test without injecting anything (just insert and remove the needle, do not inject air or anything into yourself!!!!)
yes, it is possible to do monotherapy with patches, but it depends a lot on the levels you are able to reach. it may require multiple patches and can be expensive, but it is definitely possible
monotherapy with sublingual is also possible but trickier because sublingual levels are really unstable. sublingual is also not ideal because youll always end up swallowing some of it
this may help:
https://transfemscience.org/articles/e2-equivalent-doses/

>>40766339
you wont masculinize if you do mono correctly, no spike

>>40750176 (OP)
I've been on hrt for about 9 months now and each time I get bloodwork done, my E levels drop. Total estrogens are now at 403. I'm considering upping my dose from 4mg sublingual daily to 6, but I keep seeing conflicting info. I'm also on 50mg bica daily if that matters. Just asking for advice, I guess

>>40764079
>if youre really worried about this, try to get GnRH modulators or an orchi, considering that you dont want to do E mono.
i figure I'm probably just over concerned as I'm waiting for E to arrive. ill reevaluate when i run low and decide from there. very much appreciate the information here, thank you.

>>40766896
I've never actually tried because I've been on oral hrt since the beginning of my transition but the rest seems really scary so I haven't asked about injections yet ;-;
>>40767113
all of this is really helpful m I'll probably end up speaking to my doctor about injections.

>>40752550
subq: listen to music or have a tv show you like playing to help lower the volume on anxiety while you do it. make sure you have the estradiol vial, two alcohol wipes, and a small gauge insulin syringe (in my experience these are least painful and scary for unease with needles). I use 0.3cc x 31g, x 5/16 inch needle, since I inject 0.13 mL of 40mg/mL estradiol valerate every 5 days. I bought my needles online from medical-and-lab-supplies com since Im in USA. for injecting: the vial usually has a little metal tab over the rubber stopper on top. you want to remove the tab so it reveals a hole where the rubber is. clean the rubber for 10-20 seconds with the alcohol wipe. then use the 2nd alcohol wipe to clean where you are going to inject for 10-20 secs. i like to inject into the fat on my stomach, swtiching btwn right and left side of my belly button each time i inject, but you can do thighs or buttock too, if thats easier or you dont have lots of fat on your stomach. next, pull back the plunger on your needle to the amt of mL you want to inject, then stick the needle into the rubber stopper on the vial and tilt the vial upside down. push the plunger in on the needle and then pull it back out to a few ticks higher than that mL and wait (can take a while with insulin syringe) for the liquid to fill up the syringe to the plunger. you pull out more liquid than you need bc there will be bubbles and you want to push it back in a little and tap the syringe to get them out. but for subq if there are still some small bubbles near the tip of the syringe its ok. once the syringe is filled correctly you remove it from the vial and I just try to stick it into myself quickly and push the plunger in, then count to 10 and remove it from my stomach. i also pinch the fat together where i am doing it with my other hand so I have a good spot to inject in. idk if this helps. you can watch video on youtube for subq injection.

>>40752550
for boofing prog i do it right after I poop in the morning (i mean this only works if you are really regular and consistent ig), but what helps is just like lubing yourself with something like vaseline or some kind of cream. i also coat the prog in a small dab of lotion and i spit on it, bc i think the enzymes in spit helps dissolve the capsule? idk. it helps lube it anyway. then try to press it inside you while relaxing,. once you get it in your body will suck it up inside.

>>40750176 (OP)
is it normal to be repulsed by sex after only 4 months of hrt

>>40767991
yes

>>40766524
look up ShotBlocker. these little cheap plastic things my ftm roommate uses that trick your brain/nerves into not noticing the injection.

>>40768014
will it come back?

>>40768050
i didn't do anything sexual for about 6 months after getting on hrt and i lost two inches. then i started seeing someone and my sex drive came back but it was less visual and more focused on my feelings for her and thinking about what she could do to me, etc. wish i hadn't lost size tho, so in retrospect I should've explored ways to turn myself on before that happened. also my dick hurt really bad the first 5 or so times I got an erection again while making out and attempting to have sex.

>>40750176 (OP)
can i get advice for ftms here

bump

If just taking 50mg bicalutamide isn't enough why are my nipples so damn sore

>>40769616
bica monotherapy?

>>40769622
yeah I'm just taking 50mg and my nipples are sore af I know the dose is supposed to be higher but I think it's working already

>>40769635
it does work. its not like you wont feel anything by taking just 50 mg
in studies done on men, about half of them reported tenderness and developed gyno while on 50 mg

>>40769658
so I can just take 50mg bica and I'll be fine? lol

>>40769667
what is your goal?

>>40750176 (OP)
What can i even really learn from blood tests on bicalutamide and taking sublingual pills, since my t will still be high and my e will still look low at trough levels. What should i be looking for ig

>>40769878
you can check your T levels because, depending on them, you may need to adjust your bica dosage
also, E is toxic to the testicles and may cause sustained T suppression (in the long term) even when your E levels are low between pills, again requiring you to adjust your bica dosage

>>40770046
Oh ok so just like once my t finally drops i can lower my bica dose, i was under the impression 50mg a day was fine for just about everyone. And is there any way to find out if i need like a higher e dose cuz rn I'm doing 4mg a day thinking of going to 6mg but idek what would indicate that

>>40770046
what about it is "toxic" as far as i know i dont think it really does much harm besides shrinkage and no sperm production
>>40770868
if you're on 50mg a day or like 150 once every 3 days should be fine. bica will actually raise your t levels but that t isn't binding to androgen receptors and some is even being turned into estrogen.

>>40767227
Just gonna bump this once. Lpoking for a second opinion, I guess

>>40770894
>what about it is "toxic" as far as i know i dont think it really does much harm besides shrinkage and no sperm production
estradiol has two effects:
it suppresses the HPG axis
it has direct effects on the testicles and completely alters their function independently of the HPG axis (this change may take some time to reverse and might only be partially reversible) it does not only affect sperm production, it also affects androgen production

>>40770868
your T may not drop, dont take this for granted

>>40770894
Yes I'm aware my t will raise as my body tries to compensate for the lack of testosterone actually binding, I'm just curious what i should be looking out for on sublingual + bica to know my dose is right or not
>>40771172
Will keep in mind thanks

Hello, /hrt/gen

>>40773657
Hi

>>40767931
If youre doing castor oil 31g will probably cause issues, the needle is really small and will cause a lot of tiny air bubbles when drawing, if you can even draw at all.
No need to wait 10 seconds with the alcohol wipe they work pretty much instantly. Dont hold the needle in either, once youve injected just remove it.
I would recommend once you draw from the vial to backfill another syringe so youre injecting with a fresh needle.

Any info on restarting stalled breast growth after years of hrt?

How bad cold weather is for a EV vial? I have to take it with me every time i go out in the winter. How much potency it would lose, if it were to crystalize or become cloudy even once?

>>40774835
I don't think it'll lose any potency, thermal cycling isn't great for vials though.
It's possible that the API will crash out, and in that case you may have to warm and then shake the vial until it reconstitutes.

FYI I took a normal ralo dose on top of my normal full estrogen dose and my levels got all fucked up so if you're thinking of taking raloxifene please know it might mess with your levels if you're already taking a normal estrogen dose. More details: I injected 5mg EV weekly + 100mg spiro daily + 60mg ralo daily. I was taking the ralo to try and inhibit breast growth. Took a blood test after a few months and my estrogen levels were like 2-3x what they should have been lol. For now I've just dropped ralo because I want to avoid a blood clot more than I want to avoid breast growth. For now I'm just gonna bind and hope they don't get much bigger and worst case ontario I can get a breast reduction. Thanks for reading my blog

>>40775725
what were the raw levels and is "should have been" different from a calculator or your own past levels on the dosage?

>>40775934
>raw levels
696
>your own past levels on the dosage?
desu this was the first time i've measured my estrogen levels. i was supposed to do it much earlier but i kept messing up the timing slightly lol
>calculator
according to the transfermscience.org calculator it looks like its supposed to peak at ~380 if i was just taking the injections.

page 9 /hrtgen/ bump

>>40750176 (OP)
Does anyone know anything about whether FPATH has any flexibility? Transitioning wasn’t available for me because I live in a very rural area and France only recently standardized their trans healthcare in the sense that every medical generalist has to help you but I really don’t want to go on cypro and started DIY for a few months, I.e before the standardization of care
Also is 509 pmol/L a good trough level, it seems really low

>>40779082
>Also is 509 pmol/L a good trough level, it seems really low
E monotherapy?

Bump

my first ever 2 vials of estradiol enanthate was delivered today. im planning injecting subq in tummy. previously was taking estradiol valerate sublingual coupled with cypro. sorry for blog but dont have anyone to share this info with and im excited to switch from pills

is there anything wrong with using enanthate with a little bit of valerate in it if it came from a trustworthy provider? It got tested and everything.

it's 38mg/mL Enanthate and 6mg/mL valerate but it's a really really good deal and I want to stock up on like 5 years worth.

Finger prick tests vs Venous blood test?

I don’t mind if I have to pay extra.

>>40779107
yes, intramuscular estradiol enanthate,

I'm gonna buy Astrovials and I've never done this before.

When I set the order, do I get a timer? How long is it?

Do i have to send the money using the high priority thing regardless because of how little time I get?

I have only so much money and might not have enough if I have to use BTC's high priority thing

Pls help

>>40781343
Valerate at that concentration doesn't matter. I got a few.

>>40780487
update i injected my tummy and i got scared and shaking and it went fine though it didnt hurt at all just felt weirdd

>>40781912
dont think you should be doing this because i dont think you know what you're doing. Try out sending bitcoin to your own wallet addresses a few times and get the hang of it first before trying to send a large amount and crashing out because you screwed it up. because you wont get it back.

>>40781602
first, check your T, LH, and FSH levels. do this to see if your T is fully suppressed at 509 pmol/L of E. its highly unlikely that it is suppressed because while 509 pmol/L is enough for HRT with AAs its usually not enough for monotherapy. if your T is suppressed, dont do anything. if its not suppressed, increase your levels in small steps until it is fully suppressed. this will likely happen with more than 700 pmol/L, but you might need more, like 1100 pmol/L

>>40782862
Nta - Haha that’s what I did. It was only just under £100 I lost

>>40782862
No big deal, I just have to scan the QR code and send it

>>40750176 (OP)
What's the harm of taking a little too much estrogen? Is "too much" easy or difficult to accidentally do? Is too much better than too little?

When is it good or a mistake and retarded to effectively troon out?

Bump

has anyone compared prog absorption for orally vs boofing? i want to get the most out of these pills.

>>40750176 (OP)
What do I need to test for bica liver function? Sources seem to just say "test liver function" which is incredibly vague.

>>40787575
>What's the harm of taking a little too much estrogen?
if it happens repeatedly, you will increase the risk of cardiovascular diseases. the same applies if it happens only for a short time, but the chance/harm is, obviously, much lower. its worse with oral E. the risk is still very low if you are using actual bioidentical estradiol. there are other things that can happen that are not exactly "harm", like puffy nipples, fluid retention, differences in mood and libido, etc
>Is "too much" easy or difficult to accidentally do?
depends on the route. its easy with injections. requires you to absolutely not know what youre doing with oral or sublingual/buccal, but still easy. and its difficult with transdermal
>Is too much better than too little?
depends on how low or high, and if you are doing monotherapy or not. its usually preferable to be "too much" if its just a bit over, especially if on monotherapy to guarantee T suppression

>>40790060
https://en.wikipedia.org/wiki/Pharmacokinetics_of_progesterone#Routes_of_administration
if you want a short answer, its a complete waste of time and money to take prog orally

>>40790160
its called liver panel, hepatic panel, or liver function
usually includes ALT, AST, ALP, GGT, albumin, bilirubin, and prothrombin time
if your enzymes are within the reference range, your liver can handle bica. if your liver cant handle bica properly, your enzyme levels will be higher than the reference range. if your liver completely or almost completely fails to metabolize bica, your enzymes will be much much higher
most problems will show early on as bica levels can only take up to 12 weeks to saturate
including imaging exams that cover the liver here and there are a bonus to check damage that hasnt affected liver enzymes yet if you pretend to use bica for a looong time

>>40760734
>Has been found not to antagonize the effects of androgens on bones and muscles and may even act as an agonist in those tissues
Its basically confirmed to be a partial agonist and might even switch to a full agonist (at least for crpc but the chance is still there for non-cancer tissue)

I'm about to switch to enzalutamide because of exactly that. I shed a lot of muscle the first 2y and suddenly had "remasculinization" around that time which i think is because my ARs mutated or smth

My dad also had cancer and when he was on bica, he also retained a lot of masculinity that disappeared on xtandi (backhair)

>>40790809
>Its basically confirmed to be a partial agonist and might even switch to a full agonist (at least for crpc but the chance is still there for non-cancer tissue)
it has been confirmed in animal studies, but not in humans (there are multiple studies that measured the indirect effect in humans). nilutamide was confirmed in humans IIRC. full agonism in breast and prostate cancer cells is a whole different thing, it requires multiple specific mutations in already cancerous cells for bica to become an agonist. I wouldnt worry about that
>I'm about to switch to enzalutamide because of exactly that
I not going to trust anything that interacts with androgen receptors anymore. this same effect has been seen with some progestins, spiro, bica, nilutamide, abiraterone acetate, etc. the only exceptions that I would make are, selective 17,20-lyase inhibitors and the new N-terminal domain antagonists. both havent even been launched yet
I did a ton of research before starting HRT +4 years ago but must have overlooked this effect. the result was that I spent almost the entire duration using bica, duta, and degarelix (or high E). I mainly did that because I was trying to simulate true 0 androgen levels. I havent lost any muscle strength since the start at all. not really sure about mass tho. almost no one talks about this for some reason
I re-read everything about AAs and concluded that, there is, currently, simply no good way to achieve true 0 androgens. I gave up and am now just on degarelix and E since 2 months ago, trying to be less insane about androgens, seviteronel is looking promising in the short future

>>40781912
>>40782862
Can someone please answer my questions? Does this kind of an emergency.

>>40791929
bro you don't even speak English

>>40781912
>>40791929
I don't remember there being a timer. I was at the checkout for at least an hour waiting crypto to be transferred to my crypto wallet, so i could make the purchase from astrovials.
I used Litecoin due to lower transfer fee.

You should search from reddit. You will find guides there.

>>40792118
If you want to be safe, then only once you have your crypto in your wallet ready to send, you could click order. But you can always place an order first just to know how much crypto you need, then cancel that and make a new one when you are ready to send it.

Bump

please help me, im moving to the uk soon, and i want to start using prog to grow bigger tits, where can i buy it without a prescription? i will be taking E from astrovials' EEn vial, what method should i use? rectal? and furthermore, how can i know the prog is bio identical and wont fill me with prolactin (which causes prolactinomas and stuff) due to poor chemistry?

also, i will not be able to do blood tests at all, so please tell me a dosage i can safely use to grow my boobs without having problems...

>>40795833
Why no blood test?

>>40795883
i will be staying as a tourist for a few months, no nhs rights and stuff, i dont know how to get private blood tests and that would probably be mega expensive...

>>40795901
Randox does one for £43 I think.

>>40796027
where? i went on the site and couldnt find it :,(

>>40796353
Try looking under female hormone tests

Randox is probably what I will use for my blood tests but I am tempted to attempt to see if my GP will be willing to help so I don’t have to pay £160 + per year

>>40796460
i found it, thank you :)
>>40795833
also, i wanted to add, is there anything i can do to counteract the effect of nipple darkening / vein widening? my nipples are very pink and i like them that way, and i have very thin veins, and id also like to preserve them, so, any diet changes or other medicine i can take?