Thread 40850289

New Study:
https://link.springer.com/article/10.1007/s44192-025-00216-3
Turns out troons are absolutely frying their brains with estrogen and have severely increased their risk of dementia.

>>40850289 (OP)
worth it though

>>40850289 (OP)
good, i want to fry my brain

>>40850306
i am not so sure considering you will get dementia at 50

>>40850289 (OP)
completely fine with it i'd stay on hrt even if it cut my life by half or more.

>>40850341
I could get dementia at 30 and it's still worth it. If i didn't start hormones at 14 i would probably have killed myself by now

>>40850289 (OP)
>This paper compiles several emerging and accumulating safety signals in the medical literature.
>These range from increased rates of previously associated adverse outcomes with long-term estrogen use (e.g., acute cardiovascular events) to associations of estrogen use with newly identified adverse outcomes.
>Estrogen also induces changes in the brain, raising concerns for negative impacts on mood (e.g., depression) and cognition
This is sad

I plan on killing myself when I turn 65 so whatever

>>40850289 (OP)
Then why do women that start hrt before menopause have lower risk of dementia? I don't deny it changes the brain but I don't see the correlation.

>>40850289 (OP)
Why do you type like that?

>>40850419
The Y chromosome somehow makes estrogen poisonous by a completely unknown mechanism.

The cited study mentions older (cis) women using estrogen with progestin, which I guess is a kind of synthetic prog used for birth control. How do we know prog isn't the culprit?

>>40850289 (OP)
fake news

>>40850289 (OP)
people regurgitate this exact same claim every once in a while and it always turns out to be complete bullshit if you actually read into it

>>40850289 (OP)
>The Society for Evidence-Based Gender Medicine (SEGM) is a non-profit organization that is known for its opposition to gender-affirming care for transgender youth and for engaging in political lobbying
>SEGM is closely affiliated with Genspect and Therapy First
I wish there could be just one (1) group researching trannies that wasn’t obviously biased

>>40850289 (OP)
with everything i know about hormones and endocrinology, im sorry but i straight up dont believe it. another paper in the thick pile of horseshit studies about hrt.

>>40850289 (OP)
repperchads stay winning

>>40850374
You’re going to kys regardless tbf

>>40850289 (OP)
Honestly Id eat dinner with them. They seem cool.

>>40850289 (OP)
>Antitrans group paid to find ways estrogen is bad for trannies
>Says estrogen is bad for trannies
Groundbreaking

>>40851160
I mean all the protrans studies have the same kind of bias

>>40850289 (OP)
>2025
>people STILL don't understand how science works
If it's not a peer-reviewed meta-analysis, it's astrology.

>>40850289 (OP)
>severely increased their risk of dementia
Begs the question, will dementia ridden trannies forget they transitioned? Can't wait to start finding out in 20 years.
>If it's not a peer-reviewed meta-analysis, it's astrology
Depending on the field, even that is often toilet paper.

>>40851181
yeah so you have to actually model the world and figure out if the proposed effects are at all plausible
you have to actually look at reality. there are some shortcuts that work well (looking at published work on seemingly unrelated stuff that your model predicts ought to be relevant but most people don't, because it's unlikely to have been intentionally faked to deceive you along the relevant axis) but ultimately there's no substitute for thinking it all through yourself

>>40850923
Explains why it's fake and gay

>>40851311
>Begs the question,
that's not what that means.
>will dementia ridden trannies forget they transitioned? Can't wait to start finding out in 20 years.
you retards have been jerking off to this scenario for over a decade now. you're going to keep salivating about it until we cure aging and dementia, and you're never going to see it actually happen.

my grandma had early onset dementia and my mom thinks its bc she took hrt for postmenopause stuff. idk what to think but i have a good tranny friend in her 30s who has like severe memory issues and i worry for her

>>40851181
Protrans studies tend to be about improving trans health not just saying estrogen is good. Good or bad we're gonna take it no matter what some study says.
>>40850463
Until they find the mechanism that makes this true theres no real harm

>>40850289 (OP)
They should all kill themselves via hanging

>>40851387
>that's not what that means.
Read the words literally instead of pattern matching.
>until we cure aging and dementia
Lol. Your peter pan syndrome is showing.

>>40850289 (OP)
Look at the author affiliations retard, literally the second author has no medical credentials and works for a right wing lobby

>>40851181
It all depends on your belief in the legitimacy of “gender identity” until we can understand that I don’t think there will ever be unbiased research

>>40850289 (OP)
turns out women are just retarded and biologically inferior? lol

>>40850289 (OP)
loneliness and isolation causes dementia, hrt use is only a correlation

>>40851478
It’s like MPD studies even though MPD isn’t real

>>40850289 (OP)
i like being dumb so idc my bf does all my thinking for me while i get to be his silly puppy that does all his cooking and cleaning and sucking his pp :3

>>40851442
>Your peter pan syndrome is showing.
>wow, everybody look at the faggot who thinks death and cognitive decline are bad and we should fix them. what a fucking loser.
i kind of wish it were possible for people like you to get paid some trivial amount, like 20 bucks, to put yourselves on a list of people who will never take longevity treatments. i don't actually want you to die. but i do want your future self to have the experience of looking back at what an incredibly dumb hole you dug for yourself every time you made up some bullshit to convince yourself death is good and not worth trying to escape.

>>40850289 (OP)
>Estrogen also induces changes in the brain, raising concerns for negative impacts on mood (e.g., depression) and cognition
lol is it estrogen or everyone hating us and being obsessed with us though

>>40851769
>but i do want your future self to have the experience of looking back at what an incredibly dumb hole you dug for yourself every time you made up some bullshit to convince yourself death is good and not worth trying to escape.
this world is horrible, there's nothing to cling onto

>>40851996
>estrogen makes you dumb
>trannies still need to play chess with the men tho

>>40850463
this, this, this and this. i've yet to hear *anyone* explain why this is a thing without hyperbole or bringing up hormones... where's the studies on the big picture of what makes men and women different other than chromosomal expression and hormomes present during development.. oh wait, because there's really not much to begin with..