Anonymous
ID: ezLYOjaU
7/17/2025, 9:05:17 PM No.510651647
Why aren't you biohacking?
>TAK-653 is a highly selective AMPA positive allosteric modulator that enhances cognitive function and mood
>makes information processing neurons more likely to fire. Normally when a neuron fires the other neurons around it become primed too. With something like TAK, those other neurons would also be firing and then the neurons around that would be more sensitive"
>one unique effect of AMPA PAMs is their ability to activate the precuneus in non-human primates, a brain region typically dormant during wakefulness
>the precuneus plays a key role in episodic memory, self-referential thinking, and consciousness
activation of this area while awake suggests AMPA PAMs may allow for cognitive functions normally limited to resting-state networks
>it selectively potentiates AMPA receptor activity without intrinsic agonist effects, minimizing risk of excitotoxicity and aberrant synaptogenesis
>TAK-653 has shown improvements in executive function, working memory, and cognitive flexibility, without the seizure risk associated with less selective compounds
it's also being investigated for treatment-resistant depression, producing ketamine-like antidepressant effects without impairing cognition
>other AMPA PAMs with cognitive benefits include:
>Piracetam: improves verbal memory, motor skills, visual processing
>CX516: enhances visual, spatial, and olfactory memory
>Semax: improves attention and decision-making
>Pesampator: reverses memory deficits from NMDA antagonists
>the observed precuneus activation implies enhanced connectivity in associative cortical regions
this could unlock higher-order cognition, richer autobiographical memory, and more vivid internal simulation in the waking state
https://www.reddit.com/r/NooTopics/s/wWdCyuqVGU
Here's where to buy:
everychem.com
>TAK-653 is a highly selective AMPA positive allosteric modulator that enhances cognitive function and mood
>makes information processing neurons more likely to fire. Normally when a neuron fires the other neurons around it become primed too. With something like TAK, those other neurons would also be firing and then the neurons around that would be more sensitive"
>one unique effect of AMPA PAMs is their ability to activate the precuneus in non-human primates, a brain region typically dormant during wakefulness
>the precuneus plays a key role in episodic memory, self-referential thinking, and consciousness
activation of this area while awake suggests AMPA PAMs may allow for cognitive functions normally limited to resting-state networks
>it selectively potentiates AMPA receptor activity without intrinsic agonist effects, minimizing risk of excitotoxicity and aberrant synaptogenesis
>TAK-653 has shown improvements in executive function, working memory, and cognitive flexibility, without the seizure risk associated with less selective compounds
it's also being investigated for treatment-resistant depression, producing ketamine-like antidepressant effects without impairing cognition
>other AMPA PAMs with cognitive benefits include:
>Piracetam: improves verbal memory, motor skills, visual processing
>CX516: enhances visual, spatial, and olfactory memory
>Semax: improves attention and decision-making
>Pesampator: reverses memory deficits from NMDA antagonists
>the observed precuneus activation implies enhanced connectivity in associative cortical regions
this could unlock higher-order cognition, richer autobiographical memory, and more vivid internal simulation in the waking state
https://www.reddit.com/r/NooTopics/s/wWdCyuqVGU
Here's where to buy:
everychem.com
Replies:
