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1. Direct anthelmintic effects
Papain actively digests the protective cuticle (outer protein layer) of many intestinal worms, especially:
Ascaris lumbricoides (roundworms)
Trichuris trichiura (whipworms)
Hookworms (Ancylostoma, Necator)
Tapeworms (Taenia species)
It basically "digests" the worms alive — similar to how it tenderizes meat.
This has been confirmed in multiple studies and traditional medicine reports, particularly from Africa, South Asia, and Southeast Asia.
2. Traditional and clinical evidence
Traditional use: The latex from unripe papaya fruit, sometimes mixed with honey or milk, has been used as a household dewormer in many tropical countries.
Research:
A clinical study in Nigeria (Okeniyi et al., J. Med. Food, 2007) showed that children given papaya seed extract had a 71.4% parasite clearance rate, comparable to albendazole in some cases.
Papain and related cysteine proteases from papaya have been shown in vitro to destroy helminth larvae and adult worms.
3. Mechanism of action
Proteolytic digestion of the worm’s cuticle and eggshells
Inhibition of parasite enzymes essential for metabolism
Reduction of parasite attachment to intestinal mucosa
Mild laxative effect aiding expulsion
Papain also helps digest undigested proteins and mucus, improving gut environment and reducing substrates that parasites feed on.
Papain works synergistically with:
Clove or wormwood (broad-spectrum antiparasitics)
Digestive bitters or probiotics (to restore flora)
Binders (to capture toxins after die-off)
Serrapeptidase or nattokinase (to disrupt biofilms and fibrin layers hiding worms)
