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Antidepressants can cause a range of psychological side effects, some of which may be significant and impact emotional well-being and interpersonal relationships. Common psychological side effects include feeling agitated, anxious, restless, or emotionally numb.
Some individuals report increased irritability, mood swings, or a sense of detachment from emotions and reduced concern for others, which have been described as alarmingly common but often underreported or overlooked.
Sleep disturbances are also frequently reported, including insomnia or, conversely, excessive sleepiness.
Vivid dreams or nightmares may occur, particularly when starting treatment.
Feelings of apathy and fatigue are additional psychological effects that may interfere with daily functioning and quality of life.
In more serious cases, antidepressants-especially when first started or when dosages are changed-can trigger suicidal thoughts or self-harming urges. This risk appears to be higher in younger individuals, particularly those under 25 years of age.
Over a third of respondents in one study reported experiencing suicidality as a direct result of taking antidepressants, suggesting prior research may have underestimated this risk.
Some people may also experience confusion, hallucinations, or agitation, which could be signs of serotonin syndrome-a rare but serious condition that occurs when serotonin levels become too high, often due to drug interactions.
In rare instances, antidepressants may trigger hypomania or mania, which could indicate an underlying bipolar disorder.
These psychological effects often improve after the first few weeks of treatment, but in some cases, they may persist and affect treatment adherence.
It is important to monitor these symptoms closely and discuss them with a healthcare provider, as adjustments to medication or additional support may be needed.
