Thread 16724824

Why hasn't male pattern baldness been solved yet?

>>16724824 (OP)
>Hair transplant
>Fin
It *has* been solved althougheverbeit

because not fundamentally solving it makes more money? because you can‘t solve someone else‘s nihilism?

I think its a form of aging, or has a similar function in people, and as you know you can't just cure aging yet

Or maybe I'm giving scientists too much credit, because it makes sense to assume its better to just let it persist with only slightly incrementally better drugs that must be taken chronically being able to come out

>>16724824 (OP)
It's been solved for hundreds of years, it's called a wig. Wear one.

>>16724824 (OP)
Because you're not as smart as you think you are.

>>16724824 (OP)
it can be stopped and reversed, I've seen proof of it
The downside: reduced sexual apetite from the meds

>>16724824 (OP)
nigga they cant even cure athlete's foot

>>16724824 (OP)
Because it's a marker of how much of a broke faggot loser you are. KYS

>>16724824 (OP)
Because it's a marker of how much of a broke faggot loser you are. KYS

>>16724824 (OP)
>fda nonsense is blocking it
https://newsroom.ucla.edu/magazine/baldness-cure-pp405-molecule-breakthrough-treatment

>>16724824 (OP)
They have made breakthroughs. There's a serum going through trials.

>>16725022
I'm currently using this. Did a group buy with some people who have lab contacts and we did 2 independent COAs to ensure it was the real deal. Only 1 week in so no growth yet.

But yeah once this releases for normal folk hair loss as we know it is solved.

>>16724824 (OP)
Medicine has been preoccupied playing meat mache with the genitals of the mentally ill for the past couple decades.

>>16725022
Want to make sure its safe before its released.

>>16725132
im all for safety tests, but there is more to fda red tape than safety, bureaucratic machine is notoriously slow even when all reasonable testing is done simply because of right approval papers, rechecks and the fact that most goverment employees wait until the very end of mandatory maximum time to do their work

>>16725136
Another big problem with the FDA process is ain't nobody submitting IND applications for freakin' plant extracts. Yet you look at the research, minoxidil be gettin mogged in mice: https://journals.sagepub.com/doi/full/10.1177/1934578X251333902

I plan to try out PP405 relatively soon, but my N=1 results say min already mogged by those plant extracts even in humans, but I'm only a couple months in and not using any trichoscopes.

>>16725150
they recently found some sugar that has similar results to minoxidil or sum shit

>>16724824 (OP)
Solved hundreds of years ago in Italy: Castrati.

>>16724824 (OP)
Because you have the flawed premise that it is somehow a bad thing that needs to be solved. Keep in mind it would have been filtered out by natural selection if it was really such a universally horrible thing

>>16725002

The picture on the left is from the year 2000

>In the year 2000, Elon Musk's net worth was likely around $22 million, stemming from his initial stake in Zip2, which was acquired in 1999

Nice one retard

>>16725441
2-deoxy-2-ribose. main benefits are it's cheaper than min and not toxics to cats, but it ain't some insane growth elixer and apparently the effects aren't even additive to min like many other treatments.

>>16725446
>implying androgen blockade is the ultimate hair growth hack
1990s called, they want their hair research back. ain't nobody believing some androgen-blocking monotherapy equals ultimate hair growth any more; at least upregulating some growth factors is where most research has headed.

>>16725060
In the first human trials, conducted in 2023, researchers found that application of PP405 as a topical medicine onto the scalp at bedtime for a week produced promising results.
>Only 1 week in
>so no growth yet.
>it is solved.
Fucking classic.

>>16725555
You are severely retarded.

>>16724824 (OP)

they already found the cure, it's Zinc

>>16725681
Why does this board have so many retards (such as yourself) on it?

>>16724943
this (me)

>>16725509
women didnt have a choice for most of history in their partners, wich makes your reasoning irrelevant

>>16725549
>2-deoxy-2-ribose
how to diy tho

>>16725560
>am i a sucker?
>no, everyone else is severely retarded!
Oh, that sweet, sweet cope.

>>16724824 (OP)
it literally has, its called fin or dut. everything else is just growth stimulants which only stimulate whats already there, so if you dont use a DHT blocker to protect your current follicles, the stimulants will eventually stop working because of this. anyone who tells you something else is either malicious or an idiot (tho apparently PP405 may grow new follicles, but i wouldnt hold my breath on this, and you still would want to take a DHT blocker regardless)
also fin/dut sexual sides (if you get them) go away with continued use

baldness is a social punishment for being dependent on other men. people want baldness to be a thing

>>16724824 (OP)
Anon, why do you want to look like a filthy monkey with all that hair?

>>16726225
Because I'm a white man and not a jew.

>>16724824 (OP)
It has.
Doctors will inflate ballons under your skin, stretching it and creating new skin, then that skin can cover the bald patches. A combover.
Sadly the total amount of hairs remain the same, so by doubling hair cover you halve the hair density. This isnt a serious problem, balding isnt noticeable until hair density drops to like 10% of the normal

>>16726425
bro what the fuck

>>16724824 (OP)
I think it has OP.

It's not completely done in but you're like halfway there with finasteride.

>>16724932
What

>captcha: d8hr8

>>16726425
>Sadly the total amount of hairs remain the same
Or you can find some of the literally hundreds of hair-growing chemicals out there besides "fin" and "min" to actually get more hair, LOL.

>protip: androgen pathways are mostly just a meme

>>16727208
Look downstream of androgens deep into cytokine signalling, you can find a little slice of less boomer hair therapies:
>CXCL12 Drives Reversible Fibroimmune Remodeling in Androgenetic Alopecia Revealed by Single-Cell RNA Sequencing
>https://www.mdpi.com/1422-0067/26/14/6568
>CXCL12 blockade attenuated... stromal and immune alterations, restored the regenerative capacity of DPCs, reduced pro-fibrotic macrophage infiltration, and promoted hair regrowth.

>Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals
>https://onlinelibrary.wiley.com/doi/full/10.1155/2009/491985
>genistein and DIM elicit a significantly greater cumulative effect in lowering CXCR4 and CXCL12 levels than either compound alone.

>>16725509
I don't care about women but I don't want my head to get cold and/or sunburned

>>16727208
>protip: androgen pathways are mostly just a meme
elaborate

>>16727215
any evidence that those phytochemicals (or related) can reach the follicles in concentrations that matter?
also are you implying you shouldnt use fin?

>>16727411
>https://www.tandfonline.com/doi/abs/10.3109/03639045.2010.525238
>https://www.sciencedirect.com/science/article/abs/pii/S1773224722008711
tl;dr yes

>also are you implying you shouldnt use fin?
the topical isn't that awful in terms of dick-killing at low doses usually, but it's str8 boomer therapy turned into a meme by online pharmacies when it's really just meh like min.

>>16727397
>>protip: androgen pathways are mostly just a meme
>elaborate
if you go look at clinical trials, almost nobody is developing androgen-based hair drugs anymore; it's all kinds of deranged crazy China mechanisms of action that tweak cells some other way, because fin/dut have demonstrated the limits of androgen blockade (some anti-androgenic RCs and phytochemicals are better than them, but not by too much).

>>16725022
>yet another hair growth stimulant with no effect on the cause of balding
wow it's fucking nothing

>>16727208
If I wash the chemicals out of my hair in the shower, and the chemicals drip down my back, will I grow hair on my back?

>>16728123
probably not unless they stay in contact a fairly long time

>>16725684
To give other retards (such as yourself) company.

baldness is sign that you are a man
embrace it, exercise more and grow some muscles

>>16724824 (OP)
Broken genes. My father is in his 60s and still has hair he has very few grays. Never in my family have we see the loss of hair, my uncle is 74 and while he is mostly gray he still has all the hair.

>Sinapic acid and glabridin synergistically mitigate androgenetic alopecia by modulating ferroptosis through stabilization of β-catenin against ubiquitin-dependent degradation
>https://www.sciencedirect.com/science/article/pii/S0006295225004368

>>16727367
Then wear a hat retard.

>>16730041
Oh that's a good idea, thanks anon

>>16724824 (OP)
Because the only people who care are women, and they are incompetent as a rule

>>16724824 (OP)
Because it only affects men. If women were going bald, billions would be spent trying to solve baldness and the top scientists would be working 24/7 to find a cure.

>>16730218
nobody cares, everybody cares about money, if they had a rub in oil or something that can reawaken your follicles and have your hair grow as long as you take it, they would make trillions, they would have two and a half billion customers worlwide, leave this shit at /pol/

because a man is supposed to be married and have kids before 25

Transplants are the closest thing to a fix, but they’re expensive, invasive, and limited by donor hair.

I guess I'll throw this out here.

No one in my family was ever bald (so genetics are out of the question).

>I lived in Germany for 7 years and developed baldness.

>Noticed ALOT of guys and girls are actually developing some kind of baldness in Germany.

Any science behind this phenomenon?

>>16730004
>ferroptosis
>iron
>whose alchemic symbol is mars, which also stands for male
what kind of meme is this?

>>16724824 (OP)
>Its easier to solve nuclear energy than it is to make a man pretty
Good job STEMcels

>>16724835
This. Being bald is a choice in 2025.

God he would have been such a good Lex

We have a cure but Big Woman is stopping it from being released

>>16730653
It was part of the Treaty of Versailles

>>16725066
You're acting like trannies wouldn't make up around 75% of the people getting such a treatment.

>>16724835
>look up hair transplant cost
>$10k
eh, not a choice for some people. i doubt insurance covers it.

It is solved. Use finasteride/deutasteride, plus minoxidil

>>16734557
Nice try 1997, but if you're not upregulating six kinds of growth factors you've never heard of, then you're doing it wrong.